刘光慧研究员
GuanghuiLiu,Professor

专家类别:青年****，研究员
简历&研究组工作摘要：简历1997-2002北京大学医学部，药理学学士2002-2007中国科学院生物物理研究所，理学博士2007-2009美国斯科利普斯(Scripps)研究所Researchassociate2009-2011美国索尔克(Salk)生物学研究所Researchassociate2011-今　中科院生物物理研究所，研究员，博士生导师2012年　入选中国国家青年****研究组工作摘要：1.基于多能干细胞(PSCs;包括iPSC和ESCs)的人类疾病模型、药物筛选系统和治疗体系利用病人诱导性多能干细胞（iPSC）和体外创建的“病人”胚胎干细胞（ESC），结合定向分化和细胞移植技术，在功能基因组水平研究人类疾病的分子机理及新型靶标；发展基于干细胞技术的药物筛选和评价体系；探索利用自体干细胞进行个体化治疗的可行性。2.人类健康长寿（healthyaging）的分子遗传学基础结合干细胞和基因组靶向修饰技术，研究人类衰老和老年病的细胞分子机理和遗传学基础，探索延缓衰老和防治老年病的方法和手段，以期实现“健康长寿”的梦想。更多内容请访问我的个人网站>>>http://159.226.118.206/liuLab/

Biography&IntroductionEducationandResearchExperience
1997-2002，B.S.,PekingUniversityHealthScienceCenter2002-2007，Ph.D.,InstituteofBiophysics,ChineseAcademyofSciences2007-2009，Researchassociate,Dept.ofCellandMolecularBiology,TheScrippsResearchInstitute2009-2011，Researchassociate,Geneexpressionlaboratory,TheSalkInstituteforBiologicalStudies2011-，Professor,InstituteofBiophysics,ChineseAcademyofSciences2012，ThousandYoungTalentsprogramofChinaResearchInterests1.Usingpluripotentstemcellstostudyandtreathumandiseases2.GeneticandmolecularbasisofhealthyagingAcademicAwards2012，ThousandYoungTalentsprogramofChina2012，TheExcellentYouthGrantofNSFC2011，GlennAgingFoundationfellowship2010，CaliforniaInstituteofRegenerativeMedicine(CIRM)scholartraininggrant2007，AwardbythepresidentofChineseAcademyofSciences2006，AwardbyInstituteDirector(thefirstprize)"ofInstituteofBiophysics,CAS2006，ChineseAcademyofSciences-AustraliaBHPBfellowship2006，BestOralPresentationAward"inthe10thNationalConferenceonBiophysics2004，BestPaperAward"inthe6thNationalConferenceonFreeRadicalBiologyandMedicineEditorialBoard2013-，InternationalJournalofStemCellResearchandTransplantation2012-，ProteinCell2012-，JournalofRegenerativeMedicine2012-，CellBiology:Research&Therapy　2012-，StemCellDiscovery2012-，DatasetPapersinBiology
Selectedpublications1.LiuGH¹*,QuJ1,SuzukiK1,NivetE,LiM,MontserratN,YiF,XuX,RuizS,ZhangW,RenB,WagnerU,KimA,LiY,GoeblA,KimJ,SoligallaR,DubovaI,ThompsonJ,YatesJIII,EstebanC,Sancho-MartinezI,BelmonteJC*.ProgressivedegenerationofhumanneuralstemcellscausedbypathogenicLRRK2.Nature.2012;491(7425):603-7.(*Correspondingauthor)HighlightedbyNatureReviewsNeurology(NatureReviewsNeurology|doi:10.1038/nrneurol.2012.230)2.XuX1,DuanS1,YiF,OcampoA,LiuGH^*,BelmonteJC*.Mitochondrialregulationinpluripotentstemcells.CellMetab.2013.doi:pii:S1550-4131(13)00249-0(*Correspondingauthor)3.ZhangWZ,QuJ,SuzukiK,LiuGH*,BelmonteJC*.Concealingcellulardefectsinpluripotentstemcells.TrendsCellBiol.2013.inpress(*Correspondingauthor)4.PanH1,CaiN1,LiM,LiuGH^*,IzpisuaBelmonteJC*.Autophagiccontrolofcellstemness.EMBOMol.Med.2013.Mar;5(3):327-31.(*Correspondingauthor)5.GuanD1,ZhangW1,ZhangW*,LiuGH^*,BelmonteJC*.Switchingcellfate,ncRNAscomingtoplay.CellDeathDis.2013Jan17;4:e464.(*Correspondingauthor)6.LiuGH¹*,DingZ1,IzpisuaBelmonteJC*.iPSCtechnologytostudyhumanagingandaging-relateddisorders.CurrOpinCellBiol.2012;Dec;24(6):765-74(*Correspondingauthor)7.LiM1,LiuGH¹,BelmonteJC.Navigatingtheepigeneticlandscapeofpluripotentstemcells.NatRevMolCellBiol.2012;13(8):524-35.　(¹equalcontribution)8.GiorgettiA1,MarchettoMC1,LiM1,YuD,FazzinaR,MuY,AdamoA,ParamonovI,CardosoJC,MonasterioMB,BardyC,Cassiani-IngoniR,LiuGH,GageFH,IzpisuaBelmonteJC.Cordblood-derivedneuronalcellsbyectopicexpressionofSox2andc-Myc.ProcNatlAcadSciUSA.2012;109(31):12556-61.HighlightedbyNature/SciBX(SciBX5(30);doi:10.1038/scibx.2012.798)9.LiuGH¹,SuzukiK1,QuJ1,Sancho-MartinezI,YiF,LiM,KumarS,NivetE,KimJ,SoligallaRD,DubovaI,GoeblA,PlongthongkumN,FungHL,ZhangK,LoringJ,LaurentL,andBelmonteJC.Targetedgenecorrectionoflaminopathy-associatedLMNAmutationsinpatient-specificiPSCs.CellStemCell.2011;8(6):688-94HighlightedbyNature(Nature474,8.doi:10.1038/474008c)HighlightedbyCellStemCell(CellStemCell9,2:93-94)10.LiuGH,BarkhoBZ,RuizS,DiepD,QuJ,YangSL,PanopoulosAD,SuzukiK,KurianL,WalshC,ThompsonJ,BoueS,FungHL,Sancho-MartinezI,ZhangK,IIIJY,BelmonteJC.RecapitulationofprematureageingwithiPSCsfromHutchinson-Gilfordprogeriasyndrome.Nature.2011;14;472:221-5Evaluatedby“Facultyof1000”(http://f1000.com/13411976)11.LiM,SuzukiK,QuJ,SainiP,DubovaI,YiF,LeeJ,Sancho-MartinezI,LiuGH,BelmonteJC.Efficientcorrectionofhemoglobinopathy-causingmutationsbyhomologousrecombinationinintegration-freepatientiPSCs.CellRes.2011;21(12):1740-4.Mediacoverage(www.youtube.com/watch?v=nEilyrzc9pY)
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