松田善卫研究员
ZeneMatsuda,Professor

专家类别:研究员
简历&研究组工作摘要

Biography&IntroductionM.D.KochiMedicalSchool,Japan,1985Ph.D.inMedicalScience,KochiMedicalSchool,Japan,1989D.Sc.inVirology,HarvardSchoolofPublicHealth(HSPH),USA,1993ResearchFellow/ResearchAssociate,HSPH,1993-1996SeniorResearchFellow/Chief,AIDSResearchCenter,NationalInstituteofInfectiousDiseases,Japan,1996-2006ProjectAssociateProfessor,InstituteofMedicalScience,theUniversityofTokyo,2006-2010PrincipalInvestigator,CAS,InstituteofBiophysics,2006-presentProjectProfessor,InstituteofMedicalScience,theUniversityofTokyo,2010-presentLaboratoryofStructuralVirologyandImmunologywasestablishedin2006asajointprogrambetweenInstituteofMedicalScience,theUniversityofTokyoandInstituteofBiophysics.Inourgroup,wearestudyingthestructure-functionrelationshipofviralproteinsderivedfromHIV-1,acausativeagentofAIDS.Themajortargetofourcurrentinvestigationistheenvelopeprotein(Env)andthemechanismsofmembranefusionmediatedbyEnv.Wearealsoemployingprotein-engineeringtechniquestodevelopversatilereporterproteinsusefulfortheanalysisofmembranefusion.

SelectedPublications1.IshikawaH,MengF,KondoN,IwamotoA,MatsudaZ.Generationofadual-functionalsplit-reporterproteinformonitoringmembranefusionusingself-associatingsplitGFP.ProteinEngDesSel.20122.TodaT,KuwaharaK,KondoN,MatsudaZ,MaedaY,MaedaK,SakaguchiN.DynamicappearanceofantigenicepitopeseffectiveforviralneutralizationduringmembranefusioninitiatedbyinteractionsbetweenHIV-1envelopeproteinsandCD4/CXCR4.Immunobiology.217:864-72,2012.3.LongY,MengF,KondoN,IwamotoA,MatsudaZ.Conservedarginineresidueinthemembrane-spanningdomainofHIV-1gp41isrequiredforefficientmembranefusion.ProteinCell.2:369-76.20114.LiuS,KondoN,LongY,XiaoD,IwamotoA,MatsudaZ.MembranetopologyanalysisofHIV-1envelopeglycoproteingp41.,Retrovirology.7,100,20105.MiyauchiK,CurranAR,LongY,KondoN,IwamotoA,EngelmanDM,MatsudaZ.Themembrane-spanningdomainofgp41playsacriticalroleinintracellulartraffickingoftheHIVenvelopeprotein.Retrovirology.7,95,20106.KondoN,MiyauchiK,MengF,IwamotoA,MatsudaZ.ConformationalchangesoftheHIV-1envelopeproteinduringmembranefusionareinhibitedbythereplacementofitsmembrane-spanningdomain.JBiolChem.285,14681-1468,20107.WangJ,KondoN,LongY,IwamotoA,MatsudaZ.MonitoringofHIV-1envelope-mediatedmembranefusionusingmodifiedsplitgreenfluorescentproteins.JVirolMethods.161,216-222,20098.KondoN,EbiharaA,RuH,KuramitsuS,IwamotoA,RaoZ,MatsudaZ.Thermusthermophilus-derivedproteintagsthataidinpreparationofinsolubleviralproteins.AnalBiochem.385:278-85.2009.9.MiyauchiK,CurranR,MatthewsE,KomanoJ,HoshinoT,EngelmanDM,MatsudaZ.Mutationsofconservedglycineresidueswithinthemembrane-spanningdomainofhumanimmunodeficiencyvirustype1gp41caninhibitmembranefusionandincorporationofEnvontovirions.JpnJInfectDis.59(2):77-84,2006
联系方式(Contact)：


电子邮件(E-mail)zmatsuda(AT)ibp.ac.cn
电话(Tel)
861064888571
传真(Fax)
010-64871293
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