李岩研究员（技术）
YanLi,Professor

专家类别:研究员
简历&研究组摘要1994－1998北京大学医学部（原北京医科大学）药学系，学士2000－2004美国马里兰大学化学和生物化学系，博士2004－2005美国CalibrantBiosystems生物技术公司，技术研发科学家2005－2011美国约翰霍普金斯大学医学院病理系，博士后／researchassociate2011－今中科院生物物理研究所研究员，博士生导师研究方向主要从事蛋白质组学和糖组学的生物学和临床医学的研究。研究方向主要包括以下三个方向：（1）开发以生物质谱为核心的多种蛋白质组学的分析技术和方法；（2）发展适用于生物样品和临床样品的新型糖组学的分析技术和方法；（3）在蛋白质组学和糖组学分析技术的基础上，主要开展针对蛋白质及其翻译后修饰的表达调控及其在人体功能和临床疾病中的作用机制的研究。
Biography&Introduction1994-1998　　BSinDepartmentofPharmacy,PekingUniversityHealthyScienceCenter2000-2004　　PhDinDepartmentofChemistryandBiochemistry,UniversityofMaryland2004-2005　ResearchScientistinCalibrantBiosystemsInc.2005-2011　　Researchfellow/ResearchAssociateinDepartmentofPathology,JohnsHopkinsUniversity2011-presentPrincipalInvestigatorinCASInstituteofBiophysicsProteinmodificationisoneofthesignificantmechanismsofproteinfunctionanddiseaseprogression.Myresearchinterestsfocusondeterminingproteinmodificationsassociatedwithdisease,especiallyforglycoproteinsandtheirglycosylation.Theseinclude:thedevelopmentofnewtechnologiesforlow-abundanceproteomandglycananalyses;discoveryandverifydiseasebiomarkersusinghighthroughputapproachesofclinicalproteomicsandglycomics.Theaimofourresearchesistoprovideagreaterunderstandingofhumanproteomeandglycansinthediagnosisandmanagementofhumandisease.
SelectedPublications：1.Li,Y.,Tian,Y.,Rezai,T.,Prakash,A.,Lopez,F.M.,Chan,D.W.,Zhang,H.“SimultaneousAnalysisofGlycosylatedandSialylatedPSARevealsDifferentialDistributionofGlycosylationPSAIsoformsinProstateCancerTissues”.AnalyticalChemistry.(2011)1;83(1):240-5.2.Li,Y.,Zhang,H.“HighThroughputAnalysisofGlycoproteinsfromPlasma”.MethodsMolBiol.(2011);728:125-33.3.Li,Y.,Sokoll,L.,Rush,J.,Zou,N.,Chan,D.W.,Zhang,H.“TargeteddetectionofprostatecancerproteinsinserumusingheavypeptidestandardsandMALDI-TOF/TOF”.Proteomics-ClinicalApplication(2009)3,597-608.4.Li,Y.,Sokoll,L.J.,Barker,P.E.,Chan,D.W.,Zhang,H.,“Massspectrometricidentificationofproteotypicpeptidesfromclinicallyusedtumormarkers”,ClinicalProteomics,(2008)4:58-66.5.Li,Y.,DeVoe,D.L.,Lee,C.S.,“Microfluidics-BasedProteomeAnalysis,”inProteomicsforBiologicalDiscovery(T.D.Veenstra,J.R.Yateseds.),JohnWiley&Sons,p.205,(2006).6.Li,Y.,Buch,J.S.,Rosenberger,F.,DeVoe,D.L.,Lee,C.S.,“IntegrationofIsoelectricFocusingwithParallelSDSGelElectrophoresisforMultidimensionalProteinSeparationsinaPlasticMicrofluidicNetwork”,Anal.Chem.76,742(2004).7.Cooper,J.W.,Chen,J.,Li,Y.,Lee,C.S.,“Membrane-BasedNanoscaleProteolyticReactorEnablingProteinDigestion,PeptideSeparation,andProteinIdentificationUsingMassSpectrometry”,Anal.Chem.75,1067(2003).8.Li,Y.,DeVoe,D.L.,Lee,C.S.,“DynamicAnalyteIntroductionandFocusinginPlasticMicrofluidicDevicesforProteomicAnalysis”,Electrophoresis24,193(2003).专利（Patent）1.02/03/2011　Zhang,H.,Danni,L.Meany,Li,Y.,Sokoll,L.J.,Zhang,Z.,andChan,D.W.DetectionofprostatecancerusingPSAglycosylationpatterns.TheJohnsHopkinsUniversity.(UnitedStatesPatentUS2009004365)2.08/31/2006　DeVoe,D.L,Wang,Y,Lee,C.S.Li,Y.Methodsandapparatusforporousmembraneelectrosprayandmultiplexedcouplingofmicrofluidicsystemswithmassspectrometry.CalibrantBiosystems.(UnitedStatespatent20060192107)3.06/04/2007　Zhang,H.,Li,Y.,Sokoll,L.J.,Zhang,Z.,andChan,D.W.Detectionofprostatecancerproteinsinserumforcancerdiagnosiswithabloodtest.TheJohnsHopkinsUniversity.(pending)
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