田勇研究员
YongTian,Professor

专家类别:研究员
简历&研究组工作摘要：1992-1997，北京医科大学临床医学学士1997-2002，中国协和医科大学理学博士2002-2008，美国STJUDE儿童研究医院博士后2009至今，中国科学院生物物理研究所研究员研究组工作方向：1、胚胎干细胞和诱导多能干细胞定向分化体系的研究2、疾病特异性诱导多能干细胞的研究3、神经元退行性疾病动物模型的研究4、转基因与基因敲除动物模型的研究

Biography&IntroductionEDUCATION1997-2002　　Ph.D.,Genetics　　　　　　　DepartmentofMedicalGenetics　　　　　　　PekingUnionMedicalCollege&ChineseAcademyofMedicalSciences,Beijing,China.1992-1997　　M.D.,Medicine　　　　　　　DepartmentofClinicalMedicine,SchoolofMedicine　　　　　　　BeijingMedicalUniversity,Beijing,ChinaRESEARCHEXPERIENCE2009-Present　Professor,InstituteofBiophysics,ChineseAcademyofSciences,Beijing,ChinaResearchdirection:EstablishinganimalresearchcenterinIBP,includingtransgeneandgenetargetingcorefacilityinIBP.2002-2008　PostdoctoralResearchAssociate,St.JudeChildren’sResearchHospital,Memphis,TN,USAResearchdirection:Studyingmousemodelsofhumangeneticdiseases.2000-2001　Ph.D.,co-supervisedbyDepartmentofClinicalGenetics,ErasmusUniversity,Rotterdam,theNetherlands1997-2002　Ph.D.,supervisedbyDepartmentofMedicalGenetics,PekingUnionMedicalCollege&ChineseAcademyofMedicalSciences,Beijing,ChinaResearchdirection:1、ModelinghumandiseasewithhumandiseasespecificiPSandEScelldifferentiationanditsfunctionalassay2、GenerationandcharacterizationoftransgenicandknockoutmousemodelforhumandiseaseusingTALENandEScellbasedtechniqueACADEMICSOCIETYAWARD2007　BestPosterAwardforASBMBANNUALMEETING,WASHINGTON,D.C.(ASBMB:AmericanSocietyforBiochemistryandMolecularBiology)

SelectedPublications1.　ZhangQ,WuJ,WuR,MaJ,DuG,JiaoR,TianY,ZhengZ,YuanZ.DJ-1promotestheproteasomaldegradationofFis1:implicationsofDJ-1inneuronalprotection.BiochemJ.2012Oct15;447(2):261-9.2.　WinterH,RüttigerL,MüllerM,KuhnS,BrandtN,ZimmermannU,HirtB,BressA,SausbierM,ConscienceA,FlamantF,TianY,ZuoJ,PfisterM,RuthP,L?wenheimH,SamarutJ,EngelJ,KnipperM.DeafnessinTRbetamutantsiscausedbymalformationofthetectorialmembrane.JNeurosci.2009Feb25;29(8):2581-7.3.　TianY,PateC,AndreolottiA,WangL,TuomanenE,BoydK,ClaroEandJackowskiS.CytokineSecretionRequiresPhosphatidylcholineSynthesis.JCellBiol.2008Jun;181(6):945-57.4.　GunterC,FrankM,TianY,MurtiKG,RehgJE,JackowskiS.ProbucoltherapyovercomesthereproductivedefectinCTP:phosphocholinecytidylyltransferasebeta2knockoutmice.BiochimBiophysActa.2007Jul;1771(7):845-52.5.　GaoJ,MaisonSF,WuX,HiroseK,JonesSM,BayazitovI,TianY,MittlemanG,MatthewsDB,ZakharenkoSS,LibermanMC,ZuoJ.Orphanglutamatereceptordelta1subunitrequiredforhigh-frequencyhearing.MolCellBiol.2007Jun;27(12):4500-12.6.　TianY,ZhouR,RehgJE,JackowskiS.Roleofphosphocholinecytidylyltransferasealphainlungdevelopment.MolCellBiol.2007Feb;27(3):975-82.7.　TianY,JacksonP,GunterC,WangJ,RockCO,JackowskiS.Placentalthrombosisandspontaneousfetaldeathinmicedeficientinethanolaminekinase2.JBiolChem.2006Sep22;281(38):28438-49.8.　ChowLM,TianY,WeberT,CorbettM,ZuoJ,BakerSJ.InducibleCrerecombinaseactivityinmousecerebellargranulecellprecursorsandinnerearhaircells.DevDyn.2006Nov;235(11):2991-8.9.　TianY,JamesS,ZuoJ,FritzschB,BeiselKW.Conditionalandinduciblegenerecombineeringinthemouseinnerear.BrainRes.2006May26;1091(1):243-54.10.TianY,LiM,FritzschB,ZuoJ.Creationofatransgenicmouseforhair-cellgenetargetingbyusingamodifiedbacterialartificialchromosomecontainingPrestin.DevDyn.2004Sep;231(1):199-203.11.LiM*,TianY*,FritzschB,GaoJ,WuX,ZuoJ.InnerhaircellCre-expressingtransgenicmouse.Genesis.2004Jul;39(3):173-7.(Co-firstauthor)12.　TianY,BreedveldGJ,HuangS,OostraBA,HeutinkP,LoWH.CharacterizationofZNF333,anoveldoubleKRABdomaincontainingzincfingergeneonhumanchromosome19p13.1.BiochimBiophysActa.2002Aug19;1577(1):121-5.13.　ZhaoH*,TianY*,BreedveldG,HuangS,ZouY,YJ,ChaiJ,LiH,LiM,OostraBA,LoWH,HeutinkP.PostaxialpolydactylytypeA/B(PAP-A/B)islinkedtochromosome19p13.1-13.2inaChinesekindred.EurJHumGenet.2002Mar;10(3):162-6.14.　TianY,ZhaoH,ChenJ,LiuY,LiM,YangT,LuoH,HuangS.CloningofanovelzincfingergeneZNF333anditsexpressionanalysis.BasicMedicalSciencesandClinics.2002;22(3):232-235(InChinese)15.　TianY,HuangS.Currentadvancesingeneticanalysisofhereditaryspasticparaplegia.ForeignMedicalSciences.2000;23(4):182-185(InChinese)
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