杨福全研究员
FuquanYang,Professor,Ph.D

专家类别:研究员
简历&研究组工作摘要：简历：
1983.09-1987.07郑州大学化学系，理学学士
1987.09-1992.12中国科学院兰州化学物理研究所，理学博士
1992.12-1995.06日本环境厅国立环境研究所环境化学部，博士后
1995.06-2000.12北京新技术应用研究所，北京天然产物分离纯化技术研究中心
副研究员,副主任
2000.12-2004.06访问学者,美国国家卫生研究院（NIH）国立心、肺和血液研究所(NHLBI)
访问学者
2006.07-2006.08美国Scripps研究所，高级访问学者
2004-至今：中国科学院生物物理所，研究员，质谱首席技术专家，博士生导师
研究方向：
1、疾病蛋白质组学研究与疾病相关蛋白质生物标志物的发现与鉴定
2、膜蛋白质组学和亚细胞器蛋白质组学——技术与应用
3、蛋白质翻译后修饰——技术与应用
4、蛋白质复合物的分析鉴定与蛋白质-蛋白质相互作用：技术与应用
5、定量蛋白质组学：技术与应用
Biography&IntroductionEducationandResearchExperience1983-1987ZhengzhouUniversity,Zhengzhou,China,BachelorofChemistry.　
1987-1992　LanzhouInstituteofChemicalPhysics,ChineseAcademyofSciences,
Lanzhou,China.Ph.DinAnalyticalChemistry.
1992-1995　NationalInstituteforEnvironmentalStudies,Japan　
Post-doctoralfellow.
1995-2000BeijingInstituteofNewTechnologyApplication,Beijing,China
Associateprofessor.　
2000-2004　NationalHeart,LungandBloodInstitute,NationalInstitutesofHealth,
MD,Visitingfellow.
2006.7-8　TheScrippsResearchInstitute,CA,USA.Visitingscientist
2004-currentLaboratoryofProteomics,InstituteofBiophysics,ChineseAcademyofSciences
Professor&Chiefscientistformassspectrometry.

Researchinterests
1.Discoveryandidentificationofpotentialproteinbiomarkers
2.Identificationofproteincomplex:techniqueandapplication.
3.Proteomicsofmembraneandsubcellularorganelles
4.Quantitativeproteomics:techniqueandapplication
5.Identificationofpost-translationalmodification:techniqueandapplication
6.MS-basedpeptidomics:techniqueandapplication
7.MS-basedlipidomics:techniqueandapplication
8.Separationscience:techniqueandapplicationCurrentwork
1.Developmentofnewmethodsandtechniqueforhigh-throughput,sensitiveidentificationofproteincomplex,membraneprotein,potentialproteinbiomarkersandlowabundantproteinsfrombiologicalsample.Wealsofocusonthediscoveryandidentificationofpotentialproteinbiomarkers.
2.Developmentofnewmethodsandtechniqueforhigh-throughput,sensitiveidentificationofpost-translationalmodification,includingproteinphosphorylation,glycosylation.Wealsofocusonthestudyonhistonemodifications.
3.Developmentofnewmethodsandtechniqueforquantatitiveproteomicsandtargetedproteomics.Wealsofocusontheapplicationofquantatitiveproteomicsinbiology.


SeletedPublications1.LiJ.,XieZ.,ShiL.,ZhaoZ.,HouJJ,ChenX.,CuiZ.,XueP.,CaiT.,WuP.,GuoS.,YangF.Q*.,Purification,identificationandprofilingofserumamyloidAproteinsfromseraofadvanced-stagecancerpatients,JChromatogr.B.AnalytTechnolBiomedLifeSci.,2012,889-890：3-9.2.LiuL,FengD,ChenG,ChenM,ZhengQ,SongP,MaQ,ZhuC,WangR,QiW,HuangL,XueP,LiB,WangX,JinH,WangJ,YangF,LiuP,ZhuY,SuiS,ChenQ，Mitochondrialouter-membraneproteinFUNDC1mediateshypoxia-inducedmitophagyinmammaliancells,NatCellBiol.2012,14(2):177-85.3.DingY,YangL,ZhangS,WangY,DuY,PuJ,PengG,ChenY,ZhangH,YuJ,HangH,WuP,YangF,YangH,SteinbuchelA,LiuP，IdentificationofthemajorfunctionalproteinsofProkaryoticlipiddroplets，JLipidRes.2012,53(3):399-411.4.HuZ,WangL,XieZ,ZhangX,FengD,WangF,ZuoB,WangL,LiuZ,ChenZ,YangF*,LiuL*.,Quantitativeproteomicsanalysisofparthenogeneticallyinducedpluripotentstemcells,Protein&Cell.2011,2(8):631-46.5.ZhangH,WangY,LiJ,YuJ,PuJ,LiL,ZhangH,ZhangS,PengG,YangF.Q.*,LiuP*,Proteomeofskeletalmusclelipiddropletrevealsassociationwithmitochondriaandapolipoproteina-I,JProteomeRes.2011,10(10):4757-68.6.TaoR,ChenH,GaoC,XueP,YangF,HanJD,ZhouB,ChenYG,Xbp1-mediatedhistoneH4deacetylationcontributestoDNAdouble-strandbreakrepairinyeast,CellRes.2011,21(11):1619-33.7.NiuL,XieZ,CaiT,WuP,XueP,ChenX,WuZ,ItoY,LiF,YangF.*PreparativeisolationofalkaloidsfromCorydalisbungeanaTurcz.byhigh-speedcounter-currentchromatographyusingstepwiseelution.JSepSci.2011,34(9):987-94.8.X.Duan,P.Xue,N.Wang,Z.Dong,Q.Lu,F.Q.Yang,Proteomicanalysisofaqueoushumorfrompatientswithprimaryopenangleglaucom,MolVis.2010,18(16),2839-46.9.Z.Zhao,J.Hou,Z.Xie,J.Deng,X.Wang,D.Chen,F.Q.Yang,W.Gong,Acyl-biotinylexchangechemistryandmassspectrometry-basedanalysisofpalmitoylationsitesofinvitropalmitoylatedratbraintubulin,ProteinJ.2010,29(8),531-7.10.HouJJ,XieZS,XueP,CuiZY,ChenXL,LiJ,CaiTX,WuP,YangFQ*，EnhancedMALDI-TOFMSAnalysisofPhosphopeptidesUsinganOptimizedDHAP/DAHCMatrix,JBiomed.Biotech.,2010,1-12.11.X.L.Chen,J.Li,F.Q.Yang*,“Mammalianmitochondrialproteomics：insightintomitochondrialfunctionsandmitochondria-relateddiseases”，ExpertsreviewofProteomics.2010,7(3):333-45.12.Z.YCui,J.J.Hou,X.L.Chen,J.Li,Z.S.Xie,P.Xue,T.X.Cai,P.Wu,T.Xu*,F.Q.Yang*,“BetaCellMitochondrialproteomics:fromproteinprofiletoproteinphosphorylation”,JProteomeRes,2010,9(6):2898-908.13.J.J.Hou,Z.Xie,P.Xue,Z.Cui,X.Chen,J.Li,T.Cai,P.WuandF.Q.Yang*,PhosphoproteomeAnalysisofRatL6MyotubesUsingReversed-PhaseC18PrefractionationandTitaniumDioxideEnrichment,JProteomeRes,2010,9,777–788.14.JingLi,TanxiCai,PengWu,ZiyouCui,XiulanChen,JunjieHou,ZhenshengXie,PengXue,LinanShi,PingshengLiu,JohnR.YatesIII,F.Q.Yang*,ProteomicanalysisofthemitochondriafromC.elegans,Proteomics,2009,9,4539-4553.15.Z.Y.Cui,X.L.Chen,B.W.Lu,S.K.Park,T.Xu,Z.S.Xie,P.Xue,J.J.Hou,H.Y.Hang,J.R.YatesIII*andF.Q.Yang*,PreliminaryQuantitativeProfileofDifferentialExpressionbetweenRatL6MyoblastsandMyotubesbyStableIsotopeLabelingbyAminoacidsinCellCulture,Proteomics,2009,9(5),1274-1292.16.ShiL,ZhangJ,WuP,FengK,LiJ,XieZ,XueP,CaiT,CuiZ,ChenX,HouJ,ZhangJ,YangF*.,DiscoveryandidentificationofpotentialbiomarkersofpediatricAcuteLymphoblasticLeukemia.ProteomeSci.2009,7(7):1-12.17.XieX,ChenY,XueP,FanY,DengY,PengG,YangF*,XuT*,RUVBL2,anovelAS160-bindingprotein,regulatesinsulin-stimulatedGLUT4translocation.CellRes.2009,1-8.18.ZhangX,ChenQ,FengJ,HouJ,YangF,LiuJ,JiangQ,ZhangC.SequentialphosphorylationofNedd1byCdk1andPlk1isrequiredfortargetingoftheTuRCtothecentrosome.,JCellSci.2009,122(13):2240-2251.19.LiY,LiC,XueP,ZhongB,MaoAP,RanY,ChenH,WangYY,YangF,ShuHB.,ISG56isanegative-feedbackregulatorofvirus-triggeredsignalingandcellularantiviralresponse.,ProcNatlAcadSci,2009,106(19):7945-7950.20.FanY,ShiL,YuJ,YangFQ*,WangJX*,Discoveryandidentificationofpotentialbiomarkersofpapillarythyroidcarcinoma,MolecularCancer,2009,28;8:79.21.W.He,Y.Zhao,C.Zhang,L.L.An,Z.S.Hu,Y.Liu,L.Han,L.Bi,Z.S.Xie,P.Xue,F.Q.Yang*andH.Y.Hang*,Rad9playsanimportantroleinDNAmismatchrepairthroughphysicalinteractionwithMLH1,NucleicAcidsResearch,2008,1-12.22.X.Duan,Q.Lu,P.Xue,Z.Dong,F.Q.Yang,N.L.Wang,Proteomicanalysisofaqueoushumorfrompatientswithmyopia,MolecularVision,2008,14,370-377.23.D.A.Davis,K.E.Singer,M.Sierra,M.Narazaki,F.Q.Yang,H.M.Fales,R.YarchoanandG.Tosato,IdentificationofCarboxypeptidaseNasanEnzymeResponsibleforC-TerminalCleavageofStromalCell-DerivedFactor-1aintheCirculation”,Blood,105(12)，4561-4568(2005).24.M.Sierra1,F.Q.Yang1(co-firstauthor),M.Narazaki,O.Salvucci,D.Davis,R.Yarchoan,J.Farber,H.Zhang,H.M.Fales,andG.Tosato,Differentialprocessingofstromal-derivedfactor-1AlphaandBetaexplainsfunctionaldiversity",Blood,103(7)2452-2459(2004).25.F.Q.YangandY.Ito,On-lineflow-injectiondectectionsystemanditsapplicationtothemeasurementofethanoltransferandosmosissrateincentrifugalprecipitationchromatography.J.Liq.Chroma.Rel.Tech.,27,2979-2985(2004).26.Y.Ito,F.Q.Yang,P.E.Fitze,andJ.V.Sullivan,Improvedcolumndesignforhigh-speedcountercurrentchromatography.J.Chromatogr.A.1017(2003)71-81.27.F.Q.YangandY.Ito,“Separationofalkaloidsbycountercurrentchromatography”,TheEncyclopediaofChromatogrphy(online)MarcelDekker,2003,pp1-5.28.Y.Ito,F.Q.Yang,P.E.Fitze,andJ.V.Sullivan,SpiraldiskassemblyforHSCCC:Columndesignandbasicstudiesonchromatographicresolutionandstationaryphaseretention.J.Liq.Chroma.Rel.Tech.,26(2003)1355-1372.29.F.Q.Yang,Y.Ito,Anovelmethodforthefractionationofdextranbycentrifugalprecipitationchromatography”,Anal.Chem.,74(2002)440-445.30.F.Q.YangandY.Ito,“Preparativeseparationoflappaconitine,ranaconitine,N-deacetyllappaconitineandN-deacetylranaconitinefromcrudealkaloidsofsampleAconitumsinomontanumNakaibyhigh-speedcountercurrentchromatography,J.Chromatogr.A.943(2002)219-225.31.F.Q.Yang,Y.Ma,Y.Ito,Separationandpurificationofisoflavonesfromacrudeextractfromsoybeanbyhigh-speedcountercurrentchromatography,J.Chromatogr.A.928(2001)163-170.32.F.Q.Yang,Y.Ito,"pH-Zone-refiningcountercurrentchromatographyofLappaconitinefromAconitumsinomontanumNakai:I.Separationofprepurifiedextract",J.Chromatogr.A.923(2001)281-285.33.F.Q.Yang,T.Y.Zhang,G.Q.Xu,F.E.Chou,Y.Ito,pH-modulatedstepwiseelutioncountercurrentchromatographyCCCanditsapplicationonthepreparativeseparationofhydroxyanthrquinonescompoundsfromtraditionalChinesemedicineherbs.J.Liq.Chrom.&Relat.Tech.SpecialIssueonCCC,24(2001)1617-1628.34.F.Q.Yang,T.Y.Zhang,Y.Ito,Large-scaleseparationofresveratrol,anthraglycosideAandanthraglycosideBfromPolygonumcuspidatumSieb.EtZucc.byhigh-speedcountercurrentchromatography.J.Chromatogr.A,919(2001)443-448.35.F.Q.Yang,T.Y.Zhang,Q.H.Liu,G.Q.Xu,Y.B.Zhang,Y.Ito,PreparativeisolationandpurificationofnotopterolandisoimperatorinfromChinesetraditionalmedicineNotopterygiumforbessiBoiss(QianghuoinChinese)byhigh-speedcountercurrentchromatography.J.Chromatogr.A,883(2000)67-73.36.F.Q.Yang,T.Y.Zhang,Y.Ito,PreparativeisolationandpurificationofhydroxyanthraquinonesfromRheumofficinaleBaillbyHSCCCusingpH-modulatedstepwiseelution.J.Chromatogr.A,858(1999)103-107.37.F.Q.Yang,J.Quan,T.Y.Zhang,Y.Ito,Applicationofanalyticalandpreparativehigh-speedcountercurrentchromatographyintheseparationofalkaloidsfromCoptischinensisFranch,J.Chromatogr.A,829(1998)137-141.38.F.Q.Yang,J.Quan,T.Y.Zhang,Y.Ito,"PreparativeseparationofalkaloidsfromtherootofSophoraflavescensAitbypH-zone-refiningcountercurrentchromatography".J.Chromatogr.,A.,822(1998)316-320.39.F.Q.Yang,T.Y.Zhang,andY.Ito,Multidimensionalcountercurrentchromatographyandisapplications.J.Chromatogr.A.,803,298-301(1998).40.F.Q.Yang,T.Y.Zhang,B.X.Mo,andY.Ito,Preparativeseparationandpurificationofkaempferol,isorhamnetinandquercetinbyhigh-speedcountercurrentchromatography.J.Liq.Chrom.&Rel.Technol.,21(1&2),209-216,1998.41.J.S.Edmonds,Y.Shibata,F.Q.YangandM.Morita,Isolationandsynthesisof1-Deoxy-1-dimethylarsinoylribitol-5-sulfate,anaturalconstituentofChondriacrassicaulisandotherredalgae,TetrahedronLetters,38(33),5819,1997.42.F.Q.Yang,Q.Y.Ou,W.L.Yu,Semi-preparativeseparationofaraxerylacetateandcoumarinsfromArtemisiadalailamaeKraschenbyhigh-speedcountercurrentchromatography.J.Liq.Chromatogr.,18(2),395-403,1995.
联系方式(Contact)：


电子邮件(E-mail)fqyang(AT)ibp.ac.cn
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010-64888581
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010-64871293
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