刘志杰研究员
ZhijieLiu,Professor

专家类别:百人计划,研究员
简历&研究组工作摘要：1991年－1995年中国科学院生物物理研究所,获博士学位1995年　　　　UniversityofPittsburgh，博士后1995年－2005年UniversityofGeorgia，博士后,助理研究员，副研究员2006年－　　　中国科学院生物物理研究所,“百人计划”研究员主要研究方向：天然免疫信号通路相关蛋白及其复合物的结构与功能研究；与人类肝脏疾病相关蛋白质的结构及基于结构的药物设计。结构蛋白质组学新技术和新方法的研究。更多内容请访问我的个人网站>>>http://zjliulab.ibp.ac.cn/
Biography&Introduction1995：Ph.D.ProteinCrystallography,InstituteofBiophysics,ChineseAcademyofSciences1995：Postdoc，DepartmentofCrystallography,UniversityofPittsburgh1997：Postdoc，DepartmentofBiochemistry&MolecularBiology，UniversityofGeorgia2002：AssistantResearchScientist，DepartmentofBiochemistry&MolecularBiology　UniversityofGeorgia2005：AssociateResearchScientist，SoutheastCollaboratoryforStructuralGenomics(SECSG),DepartmentofBiochemistry&MolecularBiology,UniversityofGeorgia2005：Professor，InstituteofBiophysics,ChineseAcademyofSciencesThemajorresearchinterestsarefocusedonthefollowingareas:(1)Structuralandfunctionalanalysisofproteinsandmulti-proteincomplexesininnateimmunesignalingpathway;(2)Structuralproteomicsofhumanliverdiseaserelatedproteinsandstructurebaseddrugdesign;(3)DevelopmentofnewmethodsandnewtechnologiesinproteinX-raycrystallography.VisitmyGroupPageHere>>>http://zjliulab.ibp.ac.cn/
SelectedPublications(Sincegroupestablishedin2005)1．　Niu,F.$,Shaw,N.$,Wang,Y.$,Jiao,L.$,Ding,W.,Li,X.,Zhu,P.,Upur,H.,OuYang,S*,Cheng,G*,andLiu,Z.J*,(2013)StructureoftheLeanyerOrthobunyavirusNucleoprotein-RNAcomplexrevealsnovelarchitectureforRNAencapsidation,PNAS,doi:10.1073/pnas.1300035110.($:equalcontribution)2．　Ru,H.$,Ni,X.$,Zhao,L.$,Crowley,C.,Ding,W.,Hung,L.,Shaw,N.,Cheng,G*.andLiu,Z.J*,(2013)StructuralbasisforterminationofAIM2-mediatedsignalingbyp202.CellResearch,doi:10.1038/cr.2013.52.($:equalcontribution)3．　Jiao,L.$,OuYang,S.$,N.$,Liang,M.$,Niu,F.$,Shaw,N.,Wu,W.,Ding,W.,Jin,C.,Peng,Y.,Zhu,Y.,Zhang,F.,Wang,T.,Li,C.,Zuo,X.,Luan,C.*,Li.,D.*,andLiu,Z.J*,(2013)StructureofSevereFeverwithThrombocytopeniaSyndromeVirusNucleocapsidproteininComplexwithSuraminRevealsTherapeuticPotentials.J.VI,doi:10.1128/JVI.00672-13.($:equalcontribution)4．　Won,E,Xie,Y,Takemoto,C,Chen,L,Liu,Z.J,Wang,B.C,Lee,D,Woo,E,Park,S,Shirouzu,M,Yokoyama,S,Kim,SandChi,S,(2013)High-resolutioncrystalstructureofthecatalyticdomainofhumandual-specificityphosphatase26,ActaCrystD,inpress.5．　Eremeeva,E.$,Natashin,P.$,Song,L.,Zhou,Y.,Berkel,W.,Liu,Z.J*,Vysotski,E*.,(2013)OxygenActivationofApo-obelin–CoelenterazineComplex,ChemBioChem,DOI:10.1002/cbic.201300002.($:equalcontribution)6．　OuYang,S,Song,X,Wang,Y,Ru,H.,Shaw,N.,Jiang,Y.,Niu,F.,Zhu,Y.,Qiu,W.,Parvatiyar,K.,Li,Y.,Zhang,R.,Cheng,G*.,andLiu,Z.J*,(2012)StructuralAnalysisoftheSTINGAdaptorProteinRevealsaHydrophobicDimerInterfaceandModeofCyclicdi-GMPBinding,Immunity,36(6):1073-1086.7．　Parvatiyar,K.,Zhang,Z.,Teles,R.M.,Ouyang,S.,Jiang,Y.,Iyer,S.S.,Zaver,S.A.,Schenk,M.,Zeng,S.,Zhong,W.,Liu,Z.J.,Modlin,R.L.,Liu,Y.J*.,andCheng,G*.(2012)ThehelicaseDDX41recognizesthebacterialsecondarymessengerscyclicdi-GMPandcyclicdi-AMPtoactivateatypeIinterferonimmuneresponse,NatImmunol13,1155-1161.8．　Shaw,N.,OuYang,S,andLiu,Z.J*,(2012)Bindingofbacterialsecondarymessengermoleculecdi-GMPisaSTINGoperation,Protein&Cell,Epubdate2012/12/25,DOI10.1007/s13238-012-2071-0.9．　Ru,H.,Zhao,L.,Ding,W.,Jiao,L.,Shaw,N.,Liang,W.,Zhang,L.,Hung,L.,Matsugaki,N.,Wakatsuki,S.andLiu,Z.J*,(2012)TheS-SADphasingstudyofDR6anditssolutionconformationrevealedbySAXS.ActaCryst,D68,521–530.10．　Zhan,Z.,OuYang,S.,Liang,W.,Zhang,Z.,Liu,Z.J*andHuang,L.*,(2012)StructuralandfunctionalcharacterizationoftheC-terminalcatalyticdomainoftheSSV1integrase.ActaCrystD68,659–670.11．　Hua,T.,Wu,D.,Ding,W.,Wang,J.,Neil,N*.,andLiu,Z.J*,(2012)Studiesonhuman2,4dienoylCoAreductase(DCR)shedsnewlightonperoxisomalβ-oxidationofunsaturatedfattyacids,JBiolChem,287(34):28956-65.12．　OuYang,S,Gong,B.,Li,J.,Zhao,L.,Li,C.,Wang,S.,Pan,M.,Liang,W.,Shaw,N.,Wu,W.,Zhang,F.,Sun,L.,Zheng,J.,Zhao,G.,Wang,Y.*,Liu,Z.J.*,Liang,M.*.(2012)Structuralinsightsintoahumananti-IFNantibodyexertingtherapeuticpotentialforsystemiclupuserythematosus.J.MoleMed,90(7):837-846.13．　Yoshikawa,S.,Kukimoto-Niino,M.,Parker,L.,Handa,N.,Terada,T.,Fujimoto,T.,Terazawa,Y.,Wakiyama,M.,Sato,M.,Sano,S.,Kobayashi,T.,Tanaka,T.,Chen,L.,Liu,Z.J.,Wang,B.C.,Shirouzu,M.,Kawa,S.,Semba,K.,Yamamoto,T.,Yokoyama,S.(2012)Structuralbasisforthealtereddrugsensitivitiesofnon-smallcelllungcancer-associatedmutantsofhumanepidermalgrowthfactorreceptor,Oncogene,10.1038/onc.2012.21.14．　Titushin,M.,Feng,Y.,Lee,J.,Vysotski,E.&Liu,Z.J*.(2011)Protein-proteincomplexationinbioluminescence.Protein&Cell,2(12):957-972.(Cover)15．　Liu,Z.J*,Chen,L.,Wu,D.,Ding,W.,ZhangH.,Zhou,W.,Fu,Z.&Wang,BC*,(2011)Amulti-datasetdata-collectionstrategyproducesbetterdiffractiondata.ActaCrystA67,544-549.16．　Liang,W.,SongYing,O.,Shaw,N.,Joachimiak,A.,Zhang,RG,&Liu,Z.J*.(2011)ConversionofD-ribulose5-phosphatetoD-xylulose5-phosphate:newinsightsfromstructuralandbiochemicalstudiesonhumanRPE.FasebJ.,25(2):497-504.17．　Titushin,M.,Feng,Y.,Stepanyuk,G.,Li,Y.,Markova,S,Golz,S.,Wang,BC,Lee,J.,Wang,J.,Vysotski,E.&Liu,Z.J*.(2010)NMRderivedtopologyofaGFP-photoproteinenergytransfercomplex.JBiolChem,285(52):40891–40900.18．　Zhou,Y.,Shaw,N.,Li,Y.,Zhao,Y,Zhang,RG,&Liu,Z.J*.(2010)Structure-functionanalysisofhumanl-prostaglandinDsynthaseboundwithfattyacidmolecules.FasebJ.,24(12):4668-4677.19．　Su,J.,Li,Y.,Shaw,N.,Zhou,WH,Zhang,M.,Xu,H.,Wang,BC,&Liu,Z.J*.(2010)Crystalstructureofanovelnon-PfamproteinPF2046solvedusinglowresolutionB-factorsharpeningandmulti-crystalaveragingmethods.Protein&Cell,1(5):453–458.20．　Wu,D.,Li,Y.,Song,GJ,Zhang,R.,Joachimiak,A.,Shaw,N.,&Liu,Z.J*.(2009)StructuralbasisfortheinhibitionofhumanMTHFSbyN10-substitutedfolateanalogues.CancerResearch,69(18),7294-301.(Cover)21．　Wu,D.,Li,Y.,Song,GJ,Shaw,N.,&Liu,Z.J*.(2009)CrystalstructureofhumanesteraseD:apotentialgeneticmarkerofretinoblastoma.FasebJ.,23(5),1441-1446.22．　Song,G.,Li,Y.,Cheng,C.,Zhao,Y.,Gao,A.,Zhang,R.,Joachimiak,A.,Shaw,N.,&Liu,Z.J*.(2009)Structuralinsightintoacuteintermittentporphyria.FasebJ.,23(2),396-404.23．　NataliaMoiseeva,RobertBau,StephenD.Swenson,FrancisS.Markland,Jun-YongChoe,Liu,Z.JandMarcAllaire,(2008)Structureofacostatin,adimericdisintegrinfromSoutherncopperhead(Agkistrodoncontortrixcontortrix),at1.7?,ActaCrystD64,466–470.24．　Shaw,N.,Zhao,M.,Cheng,C.,Xu,H.,Saarikettu,J.,Li,Y.,Da,Y.,Yao,Z.,Silvennoinen,O.,Yang,J.*,Liu,Z.J*.,Wang,B.C.&Rao,Z.(2007)Themultifunctionalhumanp100protein'hooks'methylatedligands.NatStructMolBiol,14(8),779-84.25．　Shaw,N.,Cheng,C.,andLiu,Z.J*,(2007)Procedureforreductivemethylationofproteintoimprovecrystallizability.NatureProtocols，DOI:10.1038/nprot.2007.28726．　Handa,N.,Kishishita,S.,Morita,S.,Akasaka,R.,Jin,Z.,Chrzas,J.,Chen,L.,Liu,Z.J.,Wang,B.C.,Sugano,S.,Tanaka,A.,Terada,T.,Shirouzu,M.&Yokoyama,S.(2007)Structureofthehumantim44c-terminaldomainincomplexwithpentaethyleneglycol:Ligand-boundform.ActaCrystD63(12),1225-1234.27．　Kondo,N.,Nakagawa,N.,Ebihara,A.,Chen,L.,Liu,Z.J.,Wang,B.C.,Yokoyama,S.,Kuramitsu,S.Masui,R.(2007).StructureofdNTP-inducibledNTPtriphosphohydrolase:insightintobroadspecificityfordNTPsandtriphosphohydrolase-typehydrolysis.ActaCrystD63,230-9.28．　Liu,Z.J.,Stepanyuk,G.A.,Vysotski,E.S.,Lee,J.,Markova,S.V.,Malikova,N.P.,andWang,B.C.(2006).CrystalstructureofobelinafterCa²⁺-triggeredbioluminescencesuggestsneutralcoelenteramideastheprimaryexcitedstate.ProcNatlAcadSci103,2570-2575.
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