焦仁杰研究员
RenjieJiao,Professor

专家类别:研究员
简历&研究组工作摘要：　焦仁杰研究员1965年1月30日生于江苏、泰兴。1987年毕业于北京大学生物学系细胞生物学及遗传学专业，获学士学位。1991年获北京大学细胞生物学硕士学位。同年留校任教。历任助教、讲师。1999年获苏黎世大学分子生物学研究所博士学位。2004年受聘于中国科学院生物物理研究所。2011年获中国科学院优秀导师称号。现任《JournalofGeneticsandGenomics》等期刊编委，英国癌症研究基金会(CancerResearchUK)等基金评审人，《JournalofCellScience》《PLoSOne》《DevelopmentalDynamics》《Development,GenesandEvolution》等杂志论文评阅人。　焦仁杰实验室主要研究方向是：发育过程中细胞生长与代谢、增殖与分化的调节机制。至今他已在Dev.Cell,Development,Mol.Cell.Biol.,Mol.Biol.Cell,J.CellSci.,Oncogene,Dev.Biol.,Biophysic.J.,PloSOne等专业期刊上发表研究论文四十多篇。

Biography&Introduction
Prof.Dr.RenjieJiao,graduatedfromPekingUniversityin1987,receivedPh.DfromtheinstituteofmolecularbiologyatUniversityofZurich,Switzerlandin1999,appointedprofessorattheInstituteofBiophysics,CASin2004.TheJiaolabhasbeenstudyingcellularmechanismsofDrosophiladevelopmentsinceitstartedin2004.Howcellproliferationanddifferentiationarecontrolledarefundamentalquestionsofanimaldevelopment,andthusunderstandingofthesequestionswillhelptomeetchallengesofdevelopmentaldiseasesincludingcancerandaging.Ourparticularscientificgoalsaretounderstand:(i)Regulationsatthechromatinleveltocontrolcellproliferationanddifferentiation;(ii)Qualityandquantitycontrolsofproteinsofrelevantsignalingpathwaystoregulatecellproliferationanddifferentiation.Inthepastseveralyears,wehavemadethefollowingmajorachievementsindisecting:(i)EpigeneticfunctionsofdCAF-1duringDrosophiladevelopment;(ii)RolesofdRecQ4anddRecQ5inmaintaininggenomestabilityinDrosophila;(iii)SUMOylationpathwaycontrollingtissuegrowththroughmodulatingtheJNKpathway;(iiii)ProtectionofDAneuronsbydHDAC6viapromotingtocxicoligomerstoforminclusions.Currentlywearefocusingon(i)HowdCAF-1andchmregulatecellproliferationanddifferentiationatthechromatinlevel;(ii)HowF-boxproteinsregulatesignallingpathwaysthatgoverncellproliferationanddifferention;(iii)HowdHDAC6andthenervoussystemcontributetopromotecellsurvival;(iiii)Developmentofgenomicmanipulationtechniques.

SelectedPublications:OriginalResearchPapersandReviews(2010-2013-06;*correspondingauthor)1.Yu,Z.,M.Ren,Z.Wang,B.Zhang,Y.S.Rong,R.Jiao*andG.Gao*.2013.HighlyefficientgenomemodificationsmediatedbyCRISPR/Cas9inDrosophila.Genetics,2.Liu,J.andR.Jiao*.2013.TALEN-mediatedgenomicmodificationsinDrosophila.Methods,[invitedarticle]3.Yu,Z.,H.Wu,H.Chen,R.Wang,X.Liang,J.Liu,C.Li,W.-M.Deng*andR.Jiao*.2013.CAF-1promotesNotchsignalingthroughepigeneticcontroloftargetgeneexpressionduringDrosophiladevelopment.Development,inpress.4.Dui,W.,B.Wei,F.He,W.Lu,C.Li,X.Liang,J.Ma*andR.Jiao*.2013.TheDrosophilaF-boxproteindSkp2regulatescellproliferationthroughtargetingDacapofordegradation.Mol.Biol.Cell.,24:1676-1687.5.Wei,C.,J.Liu,Z.Yu,B.Zhang*,G.Gao*andR.Jiao*.2013.TALENorCas9--rapid,efficientandspecificchoicesforgenomicmodifications.J.Genet.Genomics,inpress.6.Zhang,Q.,J.Wu,R.Wu,J.Ma,G.Du,R.Jiao,Y.Tian,Z.Zheng,Z.Yuan.2012.DJ-1PromotestheProteasomalDegradationofFis1:ImplicationofDJ-1intheNeuronalProtection.Biochem.J.,447:261-269.7.Zhou,C.,H.Huang,S.Kim,H.Lin,X.Meng,K.-A.Han,A.-S.Chiang,J.W.Wang,R.Jiao,andY.Rao.2012.Moleculargeneticanalysisofsexualrejection:rolesofoctopamineanditsreceptorOAMBinDrosophilacourtshipconditioning.J.Neurosci.,32:14281–14287.8.Wu,Q.,J.Liu,Y.ChenandR.Jiao*.2012.dCAF-1-p55isessentialforDrosophiladevelopmentandinvolvedinthemaintenanceofchromosomalstability.Prog.Biochem.Biophys.,39:1073-1081.9.Dui,W.,W.Lu,J.Ma*andR.Jiao*.2012.AsystematicphenotypicscreenofF-boxgenesthroughatissue-specificRNAi-basedapproachinDrosophila.J.Genet.Genomics,39:397-413.10.Xie,G.,H.Zhang,G.Du,Q.Huang,X.Liang,J.Ma*andR.Jiao*.2012.Uif,alargetransmembraneproteinwithEGF-likerepeats,canantagonizeNotchsignalinginDrosophila.PLoSOne,7:e36362.11.Liu,J.,C.Li,Z,Yu,P.Huang,H.Wu,C.Wei,N.Zhu,Y.Shen,Y.Chen,B.Zhang,W.-M.Deng*andR.Jiao*.2012.EfficientandspecificmodificationsoftheDrosophilagenomeusinganeasyTALENstrategy.JGenetGenomics,39:209-215.12.Huang,H.andR.Jiao*.2012.Therolesofchromatinassemblyfactor1intheepigeneticcontrolofchromatinplasticity.Sci.ChinaLifeSci.,55:15-19.[invitedreview]13.Huang,H.,N.ZhuandR.Jiao*.2011.ThesumoylationpathwaymodulatesJNKsignalinginDrosophila.Prog.Biochem.Biophys.,38:568-574.[ScientificNewsandPerspectives]14.Liu,J.,Q.Wu,D.H,T.Ma,L.Du,W.Dui,X.GuoandR.Jiao*.2011.DrosophilasboregulateslifespanthroughitsfunctioninthesynthesisofcoenzymeQinvivo.J.Genet.Genomics,38:225-234.15.Huang,H.,G.Du,H.Chen,X.Liang,C.Li,N.Zhu,L.Xue,J.MaandR.Jiao*.2011.DrosophilaSmt3negativelyregulatesJNKsignalingthroughsequesteringHipkinthenucleus.Development,138:2477-2485.16.Du,G.andR.Jiao*.2011.Topreventneurodegeneration:HDAC6usesdifferentstrategiesfordifferentchallenges.Commun.Integr.Biol.,4:139-142.[Invitedreview]17.Huang,H.,Z.Yu,S.Zhang,X.Liang,J.Chen,C.Li,J.MaandR.Jiao*.2010.DrosophilaCAF-1regulatesHP1-mediatedepigeneticsilencingandpericentricheterochromatinstability.J.CellSci.,123:2853-2861.18.Yu,Z.andR.Jiao*.2010.AdvancesinDrosophilagenetargetingandrelatedtechniques.Front.Biol.,5(3):238-245.[Invitedreview]19.Chen,Y.,W.Dui,Z.Yu,C.Li,J.MaandR.Jiao*.2010.DrosophilaRecQ5isrequiredforefficientSSArepairandsuppressionofLOHinvivo.Protein&Cell.1(5):478-490.20.Du,G.,X.Liu,X.Chen,M.Song,Y.Yan,R.Jiao*andC.-C.Wang*.2010.Drosophilahistonedeacetylase6protectsdopaminergicneuronsagainstα-synucleintoxicitybypromotinginclusionformation.Mol.Biol.Cell.21:2128-2137.21.He,F.,Y.Wen,D.Cheung,J.Deng,L.J.Lu,R.Jiao*andJ.Ma*.2010.DistancemeasurementsviatheBicoidmorphogengradientinDrosophilaembryos.BMCDev.Biol.,10:80-93.22.He,F.,T.Saunders,Y.Wen,D.Cheung,R.Jiao,P.ReintenWolde,M.Howard,andJ.Ma.2010.Shapingamorphogengradientforpositionalprecision.Biophys.J.99:97-107.教材编著：1、陈毅序、焦仁杰。2011年10月。染色质可塑性与基因组稳定性（第四章）。《分子细胞生物学》（第二版）主编：陈晔光、张传茂、陈佺。清华大学出版社。北京2、焦仁杰。2011年6月。细胞核与染色质（第十一章）。《细胞生物学》（第四版）主编：翟中和、王喜中、丁明孝。高等教育出版社。北京。3、焦仁杰。2013年。表观遗传分析（第十五章）。《遗传学》（第三版）主编：戴灼华、王亚馥、张博。高等教育出版社。北京。教材翻译：1、谢更强、焦仁杰。2011年3月。精编干细胞生物学研究方法。pp408-483。科学出版社。北京。2、焦仁杰。2009年1月。精编干细胞生物学。pp56-70and90-105。科学出版社。北京。
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