孙坚原研究员
JianyuanSun,Professor

专家类别:百人计划,研究员
简历&研究组工作摘要：
1993博士，华东师范大学
1993-1997讲师，副教授，华东师范大学生物系脑功能研究室
1997-1999获马普奖学金，德国马普医学所博士后
1999-2002美国华盛顿大学麻醉系研究助理
2002-2008美国德州大学西南医学中心神经科学系研究助理教授
2008-入选中科院“百人计划”，生物物理研究所研究员
本课题组主要研究兴趣是突触囊泡释放的分子生物学和细胞生物学原理。我们结合分子生物学和生物物理学方法，探索控制神经递质精确释放的突触机制。尤其关注的课题是：1）怎样的分子生物学机制决定了神经突触钙通道与突触囊泡的耦合，这一耦合是如何调控突触囊泡释放率、释放动力学以及突触可塑性的；2）神经递质释放参与神经编码的信号机制。请访问我的个人网站>>>

Biography&IntroductionDr.SuncompletedhisPh.DandbecameafacultymemberintheDepartmentofBiologyatEastChinaNormalUniversityin1993.In1997,HedidhispostdoctoralfellowshipwithDr.WolfAlmersattheMaxPlanckInstituteforMedicineResearchinHeidelberg,Germany.During1999-2002,heworkedasaresearchassociateinDr.Ling-GangWu'slabatWashingtonUniversityinSt.Louis.In2002,hewasappointedasanassistantprofessor(researchtrack)intheDepartmentofNeuroscience,UTSouthwesternMedicalCenter,Dallas.HejoinedtheInstituteofBiophysics,ChineseAcademyofSciences,asaprincipalinvestigatorin2008.Dr.Sun’sresearchinterestsarefocusedonthemolecularandcellularmechanismofsynapticvesiclerelease.Hislaboratoryusesaninterdisciplinaryapproachwithcombinationofbiophysicsandmolecularbiologytoexplorethemechanismthatthepresynapticsecretorymachineryachievesthepreciseneurotransmitterrelease.Heisparticularlyinterestedin1).Themolecularmechanismthatdeterminesthecouplingbetweencalciumchannelsandsynapticvesiclesandhowthisspatialorganizationgovernsvesiclereleaseprobability,vesiclereleasekineticsandsynapticplasticity.2).Thesignalingmechanismsthatlinkdifferentmodesofsynaptictransmitterreleasetoneuronalcoding.VisitmyGroupPageHere>>>

SelectedPublications1.SunJ-Y*,PangZP,QinD-Q,FahimA,AdachiR,andSüdhofTC*,ADual-Ca2+-SensorModelforNeurotransmitterReleaseinacentralSynapse.NATURE,450(7170):676-683,2007
2.KhvotchevM,DulubovaI,SunJ-Y,DaiH,RizoJ,andSudhof,DualModesofMunc18-1/SNAREInteractionsAreCoupledbyFunctionallyCriticalBindingtoSyntaxin-1NTerminus,JOURNALOFNEUROSCIENCE,27(45):12147-55,2007
3.SunJ-Y*,BronkP,LiuX,HanW,SüdhofTC*.Synapsinsregulateuse-dependentsynapticplasticityinthecalyxofHeldbyaCa2+/calmodulin-dependentpathway.ProcNatlAcadSciUSA,103(8):2880-5,2006
4.PangZP,SunJ-Y,RizoJ,MaximovA,SüdhofTC.Geneticanalysisofsynaptotagmin2inspontaneousandCa2+-triggeredneurotransmitterrelease.EMBOJOURNAL,25(10):2039-50,2006(co-firstauthor)
5.Wu,X-S,SunJ-Y,EversAS,CrowderM,WuL-G,Isofluraneinhibitstransmitterreleaseandthepresynapticactionpotential,ANESTHESIOLOGY,100(3):663-670,2004
6.Sun,J-Y,WuW,WuX-S,JinS-X,DondzilloA,WuL-G,CapacitanceCapacitancemeasurementsatthecalyxofHeldinthemedialnucleusofthetrapezoidbody,JOURNALOFNEUROSCIENCEMETHOD,134(2):121-131,2004
7.SunJ-Y,WuX-S,Wu,L-G,Singleandmultiplevesiclefusioninducedifferentratesofendocytosisatacentralsynapse,NATURE,417(6888):555-559,2002.(co-firstauthor)
8.SunJ-Y,WuL-G,FastKineticsofexocytosisrevealedbysimultaneousmeasurementsofpresynapticcapacitanceandpostsynapticcurrentsatacentralsynapse,NEURON,30:171-182,2001.
(*Correspondingauthor)
联系方式(Contact)：


电子邮件(E-mail)jysun(AT)ibp.ac.cn（请将(AT)替换为@，防止垃圾邮件
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