吴瑛教授
JaneYingWu,MD,Ph.D.,Prof.

专家类别:博士，高级研究顾问，****
简历&研究组工作摘要：简历：1980-1986上海医科大学，医学学士1986-1991美国斯坦福大学，博士1991-1994美国哈佛大学，博士后1994-2003美国华盛顿大学医学院，助理教授、副教授2003-2005美国Vanderbilt大学，教授2005-　美国西北大学医学院，Lurie癌症中心，CharlesLuisMix教授2008-　中国科学院生物物理研究所，高级顾问研究员研究组工作摘要：本研究组主要研究参与神经发育和神经推行性病变的基因调控的分子机制。具体研究内容分为两个方面:1）RNA调控；2）细胞迁移的分子机制。请访问我的个人网站>>>http://depot.northwestern.edu/jwn341/public_html/课题组成员：吴瑛，博士，教授，高级研究顾问朱笠，博士，副研究员刘江红，硕士，高级工程师孔瑞瑞，博士，助理研究员博士生：文普帅、杨梦雪、陈萌萌、邓健文、张韵佳硕博连读生：王鹏、邵攀

Biography&IntroductionEducation1980-1986ShanghaiMedicalUniversity，China,MDequivalent1986-1991StanfordUniversity,USA,PhDinCancerBiologyPositionsHeld1991-1994PostdoctoralFellow,HarvardUniversity1994-2000AssistantProfessor,Pediatrics,MolecularBiology&Pharmacology,WashingtonUniversitySchoolofMedicine,St.Louis2001-2003AssociateProfessorwithtenure,Pediatrics,MolecularBiology&Pharmacology,WashingtonUniversitySchoolofMedicine,St.Louis2003-2005Professorwithtenure,Pediatrics,MolecularBiology&Pharmacology,VanderbiltUniversityMedicalCenter2005-　CharlesLuisMixProfessor,Neurology,CenterofGeneticMedicine,LurieCancerCenter,NorthwesternUniversity,SchoolofMedicine2008-　SeniorConsultingInvestigator,InstituteofBiophysics,ChineseAcademyofSciencesBeijing,ChinaResearchInterestWuLaboratoryseekstounderstandthemolecularmechanismsofgeneregulation,particularlythoseinvolvedinneuraldevelopmentandneuraldegeneration.Wearefocusingontwoareas,RNAregulationandmechanismsunderlyingcellmigration.VisitmyHomePageHere>>>http://depot.northwestern.edu/jwn341/public_html/GroupMembersWUJaneYing,M.D.,Ph.D.,SeniorConsultingInvestigatorZHULi,Ph.D.,AssociateInvestigator(zhuli@moon.ibp.ac.cn)LIUJianghong,M.S.,SeniorEngineer(liujh@ibp.ac.cn)KONGRuirui,Ph.D.,AssistantInvestigatorPh.D.Students:WENPushuai,YANGMengxue,CHENMengmeng,DENGJianwen,ZANGYunjia.GraduateStudents：WANGPeng,SHAOPan.

SelectedPublications：1.　LiY,RayP,RaoEJ,ShiC,GuoW,ChenX,WoodruffEA,FushimiK,WuJY*.ADrosophilamodelforTDP-43proteinopathy.Proc.Natl.Acad.Sci.USA.2010;107:3169-74.2.　GuoW,LiJT,PanX,WeiL,WuJY*.CandidateMycobacteriumtuberculosisgenestargetedbyhumanmicroRNAs.ProteinCell.2010;1(5):419-21.3.　GuoW,ChenY,ZhouX,KarA,RayP,ChenX,RaoEJ,YangM,YeH,ZhuL,LiuJ,XuM,YangY,WangC,ZhangD,BigioEH,MesulamM,ShenY,XuQ,FushimiK,WuJY*.AnALS-associatedmutationintheTDP-43geneenhancesproteinaggregation,fibrilformationandneurotoxicity.NatStructMolBiol.2011Jun;18(7):822-30.4.　ChenY,YangM,DengJ,ChenX,YeY,ZhuL,LiuJ,YeH,ShenY,LiY,RaoEJ,FushimiK,ZhouX,BigioEH,MesulamM,XuQ,WuJY*.ExpressionofhumanFUSproteinindrosophilaleadstoprogressiveneurodegeneration.ProteinCell.2011Jun;2(6):477-86.5.　ZhuL,MillenL,MendozaJL,ThomasPJ.Auniqueredox-sensingsensor-IImotifintorsinAplaysacriticalroleinnucleotideandpartnerbinding.JBiolChem.2010;285:37271-80.6.　YeH,ZhaoT,TanYL,LiuJ,PallenCJ,XiaoZC.Receptor-likeprotein-tyrosinephosphatase{alpha}enhancescellsurfaceexpressionofneuraladhesionmoleculeNB-3.JBiolChem.2011Jul;286(29):26071-80.7.　XuY,YeH,ShenY,XuQ,ZhuL,LiuJ,WuJY*.Dscammutationleadstohydrocephalusanddecreasedmotorfunction.ProteinCell.2011Aug;2(8):647-55.8.　朱笠,刘江红,吴瑛.转录后基因调控异常与老年性痴呆.生物化学与生物物理进展.201239:703-8.9.　ZhuL,LiuJ,WuJY.Impairedpost-transcriptionalregulationinAlzheimer’sdisease.ProgBiochemBiophys.2012;39:703-8.(invitedreview)10.LiuK,LiuY,MoW,QiuR,WangX,WuJYandHeR*.MiR-124regulatesearlyneurogenesisintheopticvesicleandforebrain,targetingNeuroD1.NucleicAcidsRes.2011;39(7):2869-79.11.QiuR,LiuK,LiuY,MoW,FlyntAS,PattonJG,KarA,WuJYandHeR*.TheroleofmiR-124ainearlydevelopmentoftheXenopuseye.MechDev.2009;126(10):804-16.12.QiuR,LiuY,WuJY,LiuK,MoWandHeR*.MisexpressionofmiR-196ainduceseyeanomalyinXenouslaevis.BrainResearchBulletin.2009;76:26-31.EditedBooks：1.　KongR,RayP,YangM,WenP,LiuJ,FushimiK,KarA,LiuY,HeR,KuoD,ZhuL,WuJY.Alternativepre-mRNAsplicing,celldeath,andcancer.InRNAandCancer(WuJYeds),Springer2012;ISBN978-3-642-31658-62.　ChenM,DengJ,YangM,KuoD,ZhuK,LiuJ,ZhuL,WuJY.NoncodingRNAs,neurodevelopment,andneurodegeneration.InPosttranscriptionalGeneRegulation:RNAProcessinginEukaryotes(WuJYeds),Wiley-VCH2012;ISBN978-3-527-32202-2.

联系方式(Contact)：


电子邮件(E-mail)jane-wu@northwestern.edu
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010-64888489
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