袁增强研究员
ZengqiangYuan,Professor

专家类别:杰出青年，百人计划,研究员
简历&研究组工作摘要：学习及工作简历1991-1995年，青岛大学医学院，临床医学学士；1995-1998年，解放军总医院，病理生理学硕士；1998-2003年，南佛罗里达大学，理学博士；2003-2007年，哈佛医学院病理系，博士后；2007年至今，中国科学院“百人计划”，生物物理研究所研究员，博士生导师。2011年，获“国家杰出青年科学基金”资助研究方向随着人口老龄化的不断加剧，神经系统疾病，尤其是老年性痴呆症、帕金森氏病等神经退行性病变和脑血管疾病的发病率呈逐年递增和年轻化趋势，对上述重大疾病分子病理学机制及防治措施的研究尤为重要。我们课题组利用果蝇、小鼠等动物疾病模型和分子生物学手段及信号转导技术来研究并阐明上述疾病发生发展的分子机制，为临床疾病的诊疗提供理论基础。具体研究方向包括：（1）蛋白激酶Hippo/MST在氧化压力诱导的神经细胞凋亡和神经退行性疾病中的功能及其信号转导调节机制；（2）线粒体形态和功能动态调节的分子信号转导机制，特别是帕金森病相关基因DJ-1、Parkin和Pink等的功能和分子调控机制；（3）老年痴呆症相关基因CALHM家族蛋白的在体功能研究；（4）蛋白质翻译后修饰（磷酸化、泛素化、乙酰化等）在肿瘤和神经干细胞中的功能及其调节机制。目前已发表论文26篇，分别刊登在Science，Cell，Neuron,JNeuroscience，JBiolChem等国际权威杂志；并多次受邀在国际学术会议上做报告；目前担任EMBOJ，JMCB，JRSTR，BMCNeuroscience，Neuroregeneration，FEBSLetters，MolecularBiologyReports，ScienceChina，ChineseJournalofCancer等杂志的特邀审稿人。项目资助：1.国家自然科学基金“面上项目”(2009-2011，课题负责人)批准号：308707922.蛋白质重大计划（2009-2013，课题负责人）课题号：2009CB9187043.国家自然科学基金“重点项目”（2011-2014，课题负责人）批准号：810300254.国家杰出青年科学基金（2012-2015，课题负责人）5.蛋白质重大计划（2011-2016，学术骨干）

Biography&IntroductionEducation1990-1995,B.S.,ClinicalMedicine,QingdaoMedicalCollege.1995-1998,M.S.,Pathophysiology,ChinesePLAGeneralHospital.1998-2003,Ph.D.,Biochemistry,TheUniversityofSouthFlorida,Tampa,FL.PositionsHeld2003-2007,Postdoctoralfellow,HarvardMedicalSchool,Boston,MA
2007-present,Professor,InstituteofBiophysics,ChineseAcademyofSciences.2011,Supportedby“TheNationalOutstandingYouthGrant”ofNSFC.ResearchInterestsOurlong-termgoalistoinvestigatethemolecularmechanismsregulatingneuronalcelldeathinneurodegenerativediseasesincludingAlzheimer’sDisease(AD),Parkinson’sDisease(PD)andothercerebral/cardiovasculardiseases,byusingDrosophilaandmiceasmodelsystems.Wearealsointerestedindeterminingthesignalingtransductioninthedynamicalregulationofmitochondrialfunctioncontributingtoneurologicaldisordersaswellasthemolecularsignalingintumorigenesis.Inmylaboratory,weemployacombinationofmolecularandcellbiologicalandgeneticapproachesintheprimaryculturedneuronsandanimalmodels.Ourresearchhasbeenfocusingonthefollowingaspects:(1)Theregulatorymechanismsofthepro-apoptoticproteinkinaseHippo/MSTduringOxidativeStress-inducedneuronalcelldeath.(2)Themolecularmechanismsintheregulationofmitochondrialfunctionandmorphology,especiallythePD-relatedgenes(DJ-1,ParkinandPink1).(3)ThefunctionofCALHMfamilyproteinsinthedevelopmentofADandimmunesystemdiseases.(4)Post-translationalmodificationofthekeyproteinsandthesignalingtransductioncascadeunderlyingthedevelopmentofneurodegenerativediseasesandcancer,includingproteinphosphorylation,uniquitination,acetylationandmethylation.Insum,withthemolecularunderpinningsofsignalingmechanismintheneurologicaldiseasesareunraveled,themoreopportunitieswearelikelytogainnovelinsightsinthepathogenesisofneurodegenerativediseases,whichmightpaveanewtherapeuticavenueforthediagnosisandtreatmentofthepatients.Byusingthesimilarstrategy,wearecarryingoutthesignalingstudiesontumorigensisbasedonourunderstandingofmolecularmechanismscontrollingcellsurvivalandapoptosis.

Selectedpublications1.WangP,BaiY,SongB,WangY,LiuD,LaiY,BiX,YuanZ.PP1A-MediatedDephosphorylationPositivelyRegulatesYAP2Activity.PLoSOne.2011;6(9):e24288.(Correspondingauthor)2.XiaoL,ChenD,HuP,WuJ,LiuW,ZhaoY,CaoM,YuanF,BiW,ZhengZ,RenJ,JiG,WangY,YuanZ.TheC-Abl-MST1SignalingPathwayMediatesOxidativeStress-InducedNeuronalCellDeath.JNeuroscience.2011;31(26):9611-9619.(Correspondingauthor)3.XieQ,BaiY,WuJ,SunY,WangY,ZhangY,MeiP,YuanZ.Methylation-MediatedRegulationofE2F1inDNADamage-inducedCellDeath.JournalofReceptorandSignalTransductionResearch.2011;31（2）：139-146.(Correspondingauthor)4.YuanF,XieQ,WuJ,BaiY,MaoB,DongY,BiW,JiG,TaoW,WangY,YuanZ.MST1promotesapoptosisthroughregulatingSirt1-dependentp53deacetylation.JBiolChem.2011Mar4;286(9):6940-5.(Correspondingauthor)5.XiaoL,YuanZ.RedemystifyingMST1/hipposignaling.ProteinandCell.2010.1(8):706-708.(Review)(Correspondingauthor)6.BiW,XiaoL,JiaY,WuJ,XieQ,RenJ,JiG,YuanZ.c-JunN-terminalkinaseenhancesMST1-mediatedpro-apoptoticsignalingthroughphosphorylationatserine82.JBiolChem.2010;285(9):6259-64.(Correspondingauthor)7.YuanZ,KimD,ShuS,WuJ,GuoJ,XiaoL,KanekoS,CoppolaD,ChengJQ.Phosphoinositide3-kinase/AktinhibitsMST1-mediatedpro-apoptoticsignalingthroughphosphorylationofthreonine120.JBiolChem.2010;285(6):3815-24.(Correspondingauthor)8.YuanZ,LehtinenMK,MerloP,VillénJ,GygiS,BonniA.RegulationofneuronalcelldeathbyMST1-FOXO1signaling.JBiolChem.2009;284(17):11285-92.9.Yuan，Z.Q.,Becker,E.B.E.,Merlo,P.,DiBacco,S.E.,Yomada,T.,Schaefer,E.M.,Bonni,A.(2008)ActivationofFOXO1byCdk1incyclingcellsandpostmitoticneurons.Science.2008Mar21;319(5870):1665-8.10.Lehtinen,M.K.*,Yuan,Z.Q.*,Boag,P.R.,Yang,Y.,Villén,J.,Becker,E.B.E.,DiBacco,S.E.,NuriadelaIglesia.,Gygi,G.,Blackwell,T.K.,Bonni,A.(2006)AConservedMST-FOXOSignalingPathwayMediatesOxidativeStressResponsesandPromotesLongevity.(*Equalcontribution)Cell.125(5):987-1001.11.Shalizi,A.*,Gaudilliere,B.*,Yuan,Z.Q.,Shirogane,T.,Stegmuller,J.,Ge,Q.Y.,Tan,Y.,Schulman,B.,Harper,J.W.,Bonni,A.(2006)ACalcium-RegulatedMEF2Sumoylation-AcetylationSwitchControlsPostsynapticDendriticMorphogenesis.(*Equalcontribution)Science.311(5763):1012-1017.12.Yuan,Z.Q.*,KimD.*,KanekoS,SussmanM,Bokoch,G.M.,Kruh,G.D.,NicosiaSV,Testa,J.R.,ChengJQ.(2005)ArgBP2gammainteractswithAktandp21-activatedkinase-1andpromotescellsurvival.JBiolChem.280(22):21483-90.(*Equalcontribution)13.Yuan,Z.Q.,Feldman,R.I.,Sussman,G.E.,Coppola,D.,Nicosia,S.V.,Cheng,J.Q.(2003)　AKT2InhibitionofCisplatin-inducedJNK/p38andBaxactivationbyphosphorylationofASK1:implicationofAKT2inchemoresistance.JBiolChem.278(26):23432-40.14.Yuan,Z.Q.,Feldman,R.I.,Sun,M.,Olashaw,N.E.,Coppola,D.,Sussman,G.E.,Shelley,S.A.,Nicosia,S.V.,Cheng,J.Q.(2002)　InhibitionofJNKbycellularstress-andTNF-inducedAKT2throughactivationoftheNF?Bpathwayinhumanepithelialcells.JBiolChem.277(33):29973-29982.15.Yuan,Z.Q.,Sun,M.,Feldman,R.I.,Wang,G.,Ma,X.,Coppola,D.,Nicosia,S.V.andCheng,J.Q.(2000)FrequentalterationsofAKT2andinductionofapoptosisbyinhibitionofphosphoinositide-3-OHkinase/Aktpathwayinhumanovariancancer.Oncogene19:2324-2330.

联系方式(Contact)：


电子邮件(E-mail)zqyuan@ibp.ac.cn
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010-64867137
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010-64867137
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