邓红雨研究员
HongyuDeng,Professor

专家类别:百人计划,研究员
简历&研究组工作摘要1992-1997年博士，美国罗彻斯特大学1998-2002年博士后，爱因斯坦医学院及加州大学洛杉矶分校2002-2004年助理研究员及助理教授，加州大学洛杉矶分校2004年11月-　研究员(“百人计划”)，中国科学院生物物理研究所主要研究方向为：病毒复制的分子机理及病毒与宿主的相互作用。目前正在从事的研究工作包括：肿瘤相关疱疹病毒的基因表达调控、基因组复制及病毒包装的机理；肿瘤相关疱疹病毒与宿主细胞和免疫系统之间的相互作用；全新基因递送载体的构建与测试；病毒性肝炎的致病机理。
Biography&Introduction1992-1997Ph.D.,UniversityofRochester,USA1998-2002Postdoctoralfellow,AlbertEinsteinCollegeofMedicine&UniversityofCaliforniaatLosAngeles2002-2004AssistantResearcher&AssistantProfessor,UniversityofCaliforniaatLosAngeles2004-presentProfessor(PrincipleInvestigator),InstituteofBiophysics,ChineseAcademyofSciencesDr.Denghasspentmuchofhercareerstudyingvirusesthatarecausativeagentsfortumors.Hermainresearchinterestsaretoinvestigatethereplicationmechanismsofvirusesandvirus-hostinteractions,soastogaininsightsintoviralpathogenesisandtodevelopbettertherapeuticsanddiagnosis.Hercurrentworkaresummarizedasfollows:1)tostudythemechanismsgoverningtranscriptionalregulation,genomereplication,andvirionmorphogenesisandegressoftumor-associatedherpesviruses;2)toinvestigatetheinteractionsbetweentumor-associatedherpesvirusesandthehostinnateandadaptiveimmunesystems,bothinvitroandinvivo;3)todevelopandtestnovelgenedeliveryvectorsbasedonamurineherpesvirus;4)toinvestigatetheunderlyingmechanismsforviralhepatitis.

SelectedPublications：Deng,H.*,JTChu,NHPark,andR.Sun.Identificationofcis-sequencesrequiredforlyticreplicationandpackagingofmurinegammaherpesvirus-68.JournalofVirology78:9123-9131,2004.(*Correspondingauthor)ArumugaswamiV.,TT.Wu,D.Martinez-Guzman,Q.Jia,H.Deng,N.Reyes,andR.Sun.ORF18isatransfactorthatisessentialforlategenetranscriptionofagammaherpesvirus.JournalofVirology80:9730-40,2006.Deng,H.,Y.Liang,andR.Sun.RegulationofKSHVlyticgeneexpression.CurrentTopicsinMicrobiologyandImmunology,312:157-83,2007.(Invitedreview)YuF.,JNHarada,HJBrown,H.Deng,MJSong,TTWu,J.Kato-Stankiewicz,CGNelson,J.Vieira,F.Tamanoi,SKChanda,andR.Sun.SystematicidentificationofcellularsignalsreactivatingKaposi’sarcoma-associatedherpesvirus.PLoSPathogens3(3):e44,2007.WongE.,TTWu,N.Reyes,H.Deng,andR.Sun.Murinegammaherpesvirus68openreadingframe24isrequiredforlategeneexpressionafterDNAreplication.JournalofVirology81:6761-6764,2007.BortzE.,L.Wang,Q.Jia,TTWu,JPWhitelegge,H.Deng,ZHZhou,R.Sun.MurineGammaherpesvirus-68ORF52EncodesaTegumentProteinRequiredforVirionMorphogenesisintheCytoplasm.JournalofVirology81:10137-10150,2007.Epub2007Jul18.J.Benach,L.Wang,Y.Chen,CKHo,S.Lee,J.Seetharaman,R.Xiao,TBActon,GTMontelione,H.Deng,R.Sun,andL.Tong.StructuralandfunctionalstudiesoftheabundanttegumentproteinORF52frommurinegammaherpesvirus-68.JournalofBiologicalChemistry282:31534-31541,2007.Epub2007Aug15.LeeS.,H.Deng*,F.Yu,W.Melega,R.Damioseaux,K.Bradley,andR.Sun*.RegulationofKSHVReactivationbyDopamineReceptor-MediatedSignalingPathways.JAcquirImmuneDeficSyndr.2008Aug15;48(5):531-40.(*Co-Correspondingauthors)DiBartoloDL,HyjekE,KellerS,GuasparriI,DengH,SunR,ChadburnA,KnowlesDM,CesarmanE.RoleofdefectiveOct-2andOCA-BexpressioninimmunoglobulinproductionandKSHVlyticreactivationinprimaryeffusionlymphoma.JournalofVirology83:4308-15,2009.YangZ.,H.Tang,H.Huang,andH.Deng*.RTApromoterdemethylationandhistoneacetylationregulationofmurinegammaherpesvirus68reactivation.PLoSOne4(2):e4556,2009.(Recommendedby“Facultyof1000Biology”：http://www.f1000biology.com/article/id/1157092/evaluation)GongD.,J.Qi,V.Arumugaswami,R.SunandH.Deng*.Identificationandfunctionalcharacterizationoftheleftoriginoflyticreplicationofmurinegammaherpesvirus-68.Virology387:285-295,2009.LiaoHI,OlsonCA,HwangS,DengH,WongE,BaricRS,RobertsRW,SunR.mRNAdisplaydesignoffibronectin-basedintrabodiesthatdetectandinhibitsevereacuterespiratorysyndromecoronavirusnucleocapsidprotein.JBiolChem.2009Jun26;284(26):17512-20.Epub2009Apr13.XuX,LouZ,MaY,ChenX,YangZ,TongX,ZhaoQ,XuY,DengH,BartlamM,andRaoZ.CrystalstructureoftheC-terminalcytoplasmicdomainofnon-structuralprotein4frommousehepatitisvirusA59.PLoSOne4(7):e6217,2009.GuoH.,WangLL,PengL.,ZhouZH,andH.Deng*.ORF33ofagammaherpesvirusencodesategumentproteinessentialforvirionmorphogenesisandegress.JournalofVirologyOct;83(20):10582-95,2009.Epub2009Aug5..LiX,FengJ,ChenS,PengL,HeWW,QiJ,DengH,SunR.Tpl2/AP-1EnhancesMurineGammaherpesvirus68LyticReplication.JVirol.2010Feb;84(4):1881-90.Epub2009Nov25.LiX,ChenS,FengJ,DengH,SunR.MycIsRequiredfortheMaintenanceofKaposi'sSarcoma-AssociatedHerpesvirusLatency.JVirol.2010Sep;84(17):8945-8.Epub2010Jun23.(*Correspondingauthor)
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