高光侠研究员
GuangxiaGao,Professor

专家类别:杰出青年，百人计划，研究员，国家人事部“百千万人才”
简历&研究组工作摘要：
　　　1988年毕业于北京大学生物系生物化学专业，获理学士学位
　　　1995年毕业于美国哥伦比亚大学生化系，获博士学位
　　　1995-1999年美国哥伦比亚大学生化系，HowardHughesMedicalInstitute博士后
　　　1999-2001年美国哥伦比亚大学生化系，AssociateResearchScientist
　　　2001年至今中国科学院“百人计划”引进回国，聘为研究员。现任生物物理研究所所长助理。现为《中国病毒学》和《病毒学报》编委，BMCMicrobiology，AssociateEditor　　　主要研究逆转录病毒复制过程中与宿主细胞作用的分子机制。建立了高通量功能基因组筛选系统，并利用此系统克隆了宿主抗病毒蛋白ZAP，为研究宿主细胞功能在逆转录病毒复制过程中的作用探索出一条新的途径；对宿主抗病毒蛋白ZAP作用机理开展了深入研究，发现ZAP能够特异性结合病毒mRNA，并招募细胞内RNA降解机器降解病毒RNA，从而抑制HIV等病毒的复制。代表性成果发表在《Science》、《ProcNatlAcadSciUSA》等国际学术期刊。
更多内容请访问我的个人网站>>>http://www.ibp.cas.cn/ggxLab/（点击图片打开网站链接）
Biography&IntroductionEducation:1988:BachelorofScience,DepartmentofBiochemistry,BeijingUniversity1995:DoctorofPhilosophy,DepartmentofBiochemistry,ColumbiaUniversity,USAProfessionalexperience:1995-1999:Postdoctoralfellow,BiochemistryDepartment,HowardHughesMedicalInstitute,ColumbiaUniversity1999-2001:AssociateResearchScientist,BiochemistryDepartment,ColumbiaUniversity2001-present:Professor,ChineseAcademyofSciencesOurresearchmainlyfocusesonthemolecularmechanismoftheinteractionbetweenretrovirusesandtheirhosts.Weestablishedahigh-throughoutgeneticscreeningsystemandclonedahostantiviralfactornamedtheZinc-fingerAntiviralProtein(ZAP)usingthissystem.Itisanovelresearchmethodtothefunctionsofhostcellsduringretroviralreplication;BycarryingoutathoroughstudyonthemechanismofhostantiviralproteinZAP,wediscoverthatZAPspecificallybindstoviralmRNA,andrecruitsRNAdegradationmachinerytoinhibitviralreplicationsuchasHIV.RepresentativePublicationsarepublishedoninternationaljournalssuchasSciences,ProcNatlAcadSciUSA,etc.

SelectedPublications：1.Zhu,Y.,Chen,G.,Lv,F.,Wang,X.,Ji,X.,Xu,Y.,Sun,J.,Wu,L.,Zheng,Y.T.,andGao,G.(2011)Zinc-fingerantiviralproteininhibitsHIV-1infectionbyselectivelytargetingmultiplysplicedviralmRNAsfordegradation,ProcNatlAcadSciUSA108,15834-15839.2.Zhong,C.,Li,C.,Wang,X.,Toyoda,T.,Gao,G.,andFan,Z.(2011)GranzymeKinhibitsreplicationofinfluenzavirusthroughcleavingthenucleartransportcompleximportinalpha1/betadimerofinfectedhostcells,CellDeathDiffer.3.Ding,J.,Su,L.,andGao,G.(2011)Hrsinhibitscitronkinase-mediatedHIV-1buddingviaitsFYVEdomain,Protein&Cell2,470-476.4.Da,Q.,Yang,X.,Xu,Y.,Gao,G.,Cheng,G.,andTang,H.(2011)TANK-bindingkinase1attenuatesPTAP-dependentretroviralbuddingthroughtargetingendosomalsortingcomplexrequiredfortransport-I,JImmunol186,3023-3030.5.ZhiHuang,XinluWangandGuangxiaGao*.AnalysesofSELEX-derivedZAP-bindingRNAaptamerssuggestthatthebindingspecificityisdeterminedbybothstructureandsequenceoftheRNA.Protein&Cell.2010,Vol.1(8),752-759.6.Ye,P.,Liu,S.,Zhu,Y.,Chen,G.,andGao,G.(2010)DEXH-BoxproteinDHX30isrequiredforoptimalfunctionofthezinc-fingerantiviralprotein,Protein&Cell1,956-964.7.Wang,X.,Lv,F.,andGao,G.(2010)Mutagenesisanalysisofthezinc-fingerantiviralprotein,Retrovirology7,19.8.Mai,Y.,andGao,G.(2010)ExpressionofIMP1enhancesproductionofmurineleukemiavirusvectorbyfacilitatingviralgenomicRNApackaging,PLoSOne5,e15881.9.Huang,Z.,Wang,X.,andGao,G.(2010)AnalysesofSELEX-derivedZAP-bindingRNAaptamerssuggestthatthebindingspecificityisdeterminedbybothstructureandsequenceoftheRNA,Protein&Cell1,752-759.10.Xu,J.,Liu,S.,Xu,Y.,Tien,P.,andGao,G.(2009)Identificationofthenonstructuralprotein4BofhepatitisCvirusasafactorthatinhibitstheantiviralactivityofinterferon-alpha,VirusRes141(1),55-62.11.Kuang,Y.Q.,Tang,X.,Liu,F.L.,Jiang,X.L.,Zhang,Y.P.,Gao,G.,andZheng,Y.T.(2009)GenotypingofTRIM5locusinnorthernpig-tailedmacaques(Macacaleonina),aprimatespeciessusceptibletoHumanImmunodeficiencyVirustype1infection,Retrovirology6,58.12.Zhu,Y.,andGao,G.(2008)ZAP-mediatedmRNAdegradation,RNABiol5,65-67.13.Chen,G.,Guo,X.,Lv,F.,Xu,Y.,andGao,G.(2008)p72DEADboxRNAhelicaseisrequiredforoptimalfunctionofthezinc-fingerantiviralprotein,ProcNatlAcadSciUSA105,4352-4357.14.Guo,X.,Ma,J.,Sun,J.,andGao,G.(2007)Thezinc-fingerantiviralproteinrecruitstheRNAprocessingexosometodegradethetargetmRNA,ProcNatlAcadSciUSA104,151-156.15.Liu,S.,Goff,S.P.,andGao,G.(2006)Gln(84)ofmoloneymurineleukemiavirusreversetranscriptaseregulatestheincorporationratesofribonucleotidesanddeoxyribonucleotides,FEBSLett580,1497-1501.16.Duan,J.,Ji,X.,Feng,J.,Han,W.,Zhang,P.,Cao,W.,Guo,X.,Qi,C.,Yang,D.,Jin,G.,Gao,G.,andYan,X.(2006)AhumanneutralizingantibodyagainstaconformationalepitopesharedbyoligomericSARSS1protein,AntivirTher11,117-123.17.Naghavi,M.H.,Hatziioannou,T.,Gao,G.,andGoff,S.P.(2005)Overexpressionoffasciculationandelongationproteinzeta-1(FEZ1)inducesapost-entryblocktoretrovirusesinculturedcells,GenesDev19,1105-1115.18.Liu,L.,Chen,G.,Ji,X.,andGao,G.(2004)ZAPisaCRM1-dependentnucleocytoplasmicshuttlingprotein,BiochemBiophysResCommun321,517-523.19.Guo,X.,Carroll,J.W.,Macdonald,M.R.,Goff,S.P.,andGao,G.(2004)ThezincfingerantiviralproteindirectlybindstospecificviralmRNAsthroughtheCCCHzincfingermotifs,JVirol78,12781-12787.20.Gao,G.,andGoff,S.P.(2004)Isolationofsuppressorgenesthatrestoreretrovirussusceptibilitytoavirus-resistantcellline,Retrovirology1,30.21.Wang,M.Q.,Kim,W.,Gao,G.,Torrey,T.A.,Morse,H.C.,3rd,DeCamilli,P.,andGoff,S.P.(2003)EndophilinsinteractwithMoloneymurineleukemiavirusGagandmodulatevirionproduction,JBiol3,4.22.Bick,M.J.,Carroll,J.W.,Gao,G.,Goff,S.P.,Rice,C.M.,andMacDonald,M.R.(2003)Expressionofthezinc-fingerantiviralproteininhibitsalphavirusreplication,JVirol77,11555-11562.23.Gao,G.,Guo,X.,andGoff,S.P.(2002)InhibitionofretroviralRNAproductionbyZAP,aCCCH-typezincfingerprotein,Science297,1703-1706.

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