侯百东研究员
BaidongHou,Professor

专家类别:研究员
简历&研究组工作摘要：
简历1989-1994:北京医科大学（现北京大学医学部），临床医学，本科1994-1997:北京协和医院，住院医师1997-2001:北京协和医科大学，博士研究生2001-2003:范德比尔特大学，博士后2003-2009:加州大学旧金山分校，博士后2009-2011:加州大学旧金山分校，助理研究员2011年至今：中国科学院生物物理所，研究员2011年11月：入选中国国家“青年****”研究兴趣：对入侵病原的快速和特异的识别是宿主进行有效抵御的前提。识别的分子基础是宿主表达多种可以感知病原分子特征的受体。它们在结合相应的病原配体后能激活多种炎症因子的表达并促进免疫细胞功能活化，在天然免疫和适应性免疫的调控中起关键作用。本课题组的研究兴趣是了解此类受体在动物体内的功能。目前的研究关注于哺乳动物表达的一类重要的病原分子特征识别受体，即Toll样受体(TLR)信号传导在感染和炎症中的作用，以及它们调节免疫细胞活化和相互作用的分子机制。主要研究方向包括明确Toll样受体信号传导（1）在炎症和感染中对不同免疫细胞的功能调节作用；（2）在黏膜免疫中的作用；（3）在自身免疫反应中的作用。阐明这些机制将有利于开发新的治疗手段和指导疫苗设计。
Biography&IntroductionBiography1989-1994:B.S.,BeijingMedicalUniversity,Beijing,China1994-1997:MedicalResident,PekingUnionMedicalCollegeHospital,Beijing,China1997-2001:M.D.,PekingUnionMedicalCollege,Beijing,China2001-2003:Postdoctoralfellow,VanderbiltUniversity,Nashville,TN,USA2003-2009:Postdoctoralfellow,UniversityofCalifornia,SanFrancisco,CA,USA2009-2011：Associatespecialist,UniversityofCalifornia,SanFrancisco,CA,USA2011topresent:Professor,InstituteofBiophysics,ChineseAcademyofScience,Beijing,ChinaNov.2011:　supportedbytheYoungThousandTalentsProgramResearchinterests:Hostdefenseagainstinvadingmicrobesrequiresrecognizingpathogen-associatedmolecularpatternsandcoordinatedinteractionsbetweendifferentimmunecelltypes.Thelong-termgoalofourresearchteamistounderstandhowimmunecellsareactivatedbypathogensandhowtheirfunctionsarecoordinatedtoeradicatethepathogen.ThecurrentresearchisfocusingonhowthesignalingofToll-likereceptors(TLRs),aprototypeofmammalian“pattern-recognizing”receptorfamily,activatesimmuneresponseinvivo.ThemainresearchaimsaretodefinetheroleofTLRsignaling(1)intheimmuneresponsetopathogens;(2)inpromotingguthomeostasisandmucosalimmunity;(3)inautoimmunediseases.
SelectedPublications：1.RaetzM,HwangSH,WilhelmCL,KirklandD,BensonA,SturgeCR,MirpuriJ,VaishnavaS,HouB,DefrancoAL,GilpinCJ,HooperLV,YarovinskyF.　Parasite-inducedT(H)1cellsandintestinaldysbiosiscooperateinIFN-γ-dependenteliminationofPanethcells.NatImmunol.2012Dec23.2.KirklandD,BensonA,MirpuriJ,PiferR,HouB,DeFrancoAL,YarovinskyF.　Bcell-intrinsicMyD88signalingpreventsthelethaldisseminationofcommensalbacteriaduringcolonicdamage.Immunity.2012Feb24;36(2):228-38.3.HuaZ,HouB.TLRsignalinginB-celldevelopmentandactivation.CellMolImmunol.2012Dec17.4.HouB*,SaudanP,OttG,WheelerML,JiM,KuzmichL,LeeL,CoffmanR,BachmannM,DeFrancoAL*.SelectiveutilizationofTLR/MyD88signalinginBcellsforenhancementoftheanti-viralgerminalcenterresponse.Immunity,34(3):375-384MAR252011.(*Co-correspondingauthor)ThisarticleisselectedandrecommendedbyFacultyof1000(http://f1000.com/9713956).　5.RahmanAH,ZhangR,BlosserCD,HouB,DeFrancoAL,MaltzmanJS,WherryEJ,andTurkaLA.Anti-viralmemoryCD8Tcelldifferentiation,maintenanceandsecondaryexpansionoccurindependentofMyD88.Blood117(11):3123-3130MAR172011.6.HouB*,BensonA,KuzmichL,DeFrancoAL,YarovinskyF*.CriticalcoordinationofinnateimmunedefensetoToxoplasmagondiibydendriticcellsrespondingviatheirToll-likereceptors.ProceedingsoftheNationalAcademyofSciencesUSA.108(1):278-283JAN42011.(*Co-correspondingauthor).7.MamchakAA,SullivanBM,HouB,LeeLM,GildenJK,KrummelMF,LocksleyLM,DeFrancoAL.NormaldevelopmentandactivationbutalteredcytokineproductionofFyn-deficientCD4+Tcells.JournalofImmunology2008Oct15;181(8):5374-858.HouB,ReizisB,DeFrancoAL.Toll-likereceptor-mediateddendriticcell-dependentand–independentstimulationofinnateandadaptiveimmunity.Immunity2008Aug;29(2):272-82.·HighlightedinNewsandView.PulendranB,CaoW.2008:AMyD88O,DC.Immunity2008Aug;29(2):173-5.·SelectedandevaluatedfortheFacultyof1000BiologyforumbyDr.MarkSmyth(http://www.f1000biology.com/article/id/1123856)9.HouB,ErenM,CovingtonJW,PainterCA,DixonJD,SchoenhardJA,VaughanDE.Tumornecrosisfactor?activatesthehumanplasminogenactivatorinhibitor-1genethroughadistalnuclearfactor?Bsite.JournalofBiologicalChemistry2004;279(18):18127-18136.10.HouB,PanJ,FanL,GaoJ.AnalysisoftheclinicalandlaboratorypatternsofDICwithdifferentprimaryetiologyandevaluationofheparintherapy.NationalMedicalJournalofChina2001;81(2):752-753.11.LiuD,DuB,LongY,ZhaoC,HouB.Rightventricularfunctionofpatientswithsepticshock:clinicalsignificance.ZhonghuaWaiKeZaZhi2000Jul;38(7):488-92
联系方式(Contact)：


电子邮件(E-mail)baidong_hou(AT)ibp.ac.cn
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010-64884501
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010-64871293
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