娄继忠研究员
JizhongLou,Professor

专家类别:研究员，百人计划
简历&研究组工作摘要：
1990–1994:吉林大学，学士
1994–1997:北京大学，硕士
1997–2000:中国科学院理论物理研究所，博士
2000–2001:内华达大学拉斯韦加斯分校，博士后
2001–2005:佐治亚理工学院，博士后
2005–2009:佐治亚理工学院，研究科学家
2009-:入选中科院“百人计划”，生物物理研究所研究员，博士生导师本研究组主要研究兴趣在于蛋白质或其它生物大分子的结构与功能以及它们同人类健康与疾病的关系。我们结合计算生物学，理论生物学和试验生物学方法来研究生物分子如何响应外界信号刺激，并在原子层次上预测生物分子构象变化及这种变化对其生物功能的影响。我们的目标是能够针对具体疾病设计可临床应用的治疗药物。

Biography&Introduction1990–1994:BSinphysics,JilinUniversity.1994–1997:MSinphysics,PekingUniversity.1997–2000:Ph.Dinphysics,Instituteoftheoreticalphysics,CAS.2000–2001:PostdoctoralFellow,UniversityofNevada,LasVegas.2001–2005:PostdoctoralFellow,GeorgiaInstituteofTechnology.2005–2009:ResearchScientist,GeorgiaInstituteofTechnology.2009-:PrincipalInvestigator,InstituteofBiophysics,CASWeinterestinthestructure-functionrelationshipofproteinsorotherbiomoleculesandtheircorrelationstohumanhealthanddiseases.Wecombinecomputational,theoreticalandexperimentalapproaches1)todeterminehowconformationsofbiomoleculesareregulatedbyexternalstimuli,2)tocharacterizethemechanismofconformationalchangesattheatomiclevel,and3)todeterminehowbiologicalfunctionsareaffectedbytheseconformationalchanges.Ourlong-termgoalistodeveloptherapeuticallyusefuldrugsforthetreatmentofdiseases.
SelectedPublications：
1.HuangQ.S.,LouJ.,WuJ.H.,andZhuC.,ConformationaltransitionsofglycoproteinIbalphamutantsinflowmoleculardynamicssimulation,Cell.Mol.Bioeng.4(3):495-504,2011.2.*YagoT.,*LouJ.,*WuT.,YangJ.,MinerJ.J.,CoburnL.,LopezJ.A.,CruzM.A.,DongJ.-F.,McIntireL.V.,McEverR.P.,andZhuC.,PlateletglycoproteinIbαformscatchbondswithWTVWFbutnotwithtype2BvonWillebrandDiseaseVWF,J.Clin.Invest.,118:3195-3207(2008).(*equalcontribution)3.ChenZ.,LouJ.,ZhuC.,andSchultenK.,FlowInducedStructuralTransitionintheβ-switchRegionofGlycoproteinIb,BiophysJ.,95:1303-1313(2008).4.LouJ.,andZhuC.,Flowinduceslooptoβ-hairpintransitionontheβ-switchofplateletglycoproteinIbα,Proc.Natl.Acad.Sci.USA,105:13847-13852(2008).5.LouJ.,andZhuC.,Astructure-basedsliding-rebindingmechanismforcatchbonds,BiophysJ.,92:1471-85(2007).6.*LouJ.,*YagoT.,*KlopockiA.G.,MethaP.,ChenW.,ZarnitsynaV.I.,BovinN.V.,ZhuC.,andMcEverR.P.,Flow-enhancedadhesionregulatedbyaselectininterdomainhinge,J.CellBiol.,174:1107-1117(2006).(*equalcontribution)7.MarshallB.T.,SarangapaniK.K.,LouJ.,McEverR.P.,andZhuC.,Forcehistorydependenceofreceptor-liganddissociation,BiophysJ.88,1458(2005).8.ZhuC.,LouJ.,McEverR.P.,CatchBonds:PhysicalModels,StructuralBases,BiologicalFunctions,andRheologicalRelevance,Biorheology42,443-462(2005).
联系方式(Contact)：


电子邮件(E-mail)jlou@ibp.ac.cn
电话(Tel)
010-64888183
传真(Fax)
010-64871293
邮政编码100101