摘要/Abstract

发展了一种环境友好的可见光诱导的反应. 该方法在简单、温和的反应条件下可以通过2-(苄基氨基)苯甲酰胺来高效合成4(3H)-喹唑啉酮化合物. 不使用任何金属、光催化剂和其他添加剂, 仅在室温下用blue LED照射, 反应就可以顺利进行并高收率得到相应的喹唑啉酮化合物. 该反应具有反应底物范围广、官能团兼容性好、操作简单等优点, 同时可进行克级反应. 机理研究表明, 该反应经历自由基历程.
关键词: 可见光, 2-(苄基氨基)苯甲酰胺, 4(3H)-喹唑啉酮
An environmental benign protocol of visible-light-induced reaction has been developed. The methodology allows effective synthesis of 4(3H)-quinazolinones from 2-benzylaminobenzamides in simple and mild reaction conditions. Just irradiation with a blue LED light at room temperature, the reaction proceeds well to provide the corresponding quinazolinones in good to high yields under metal-free, photocatalyst-free and mediator-free conditions. This protocol is demonstrated by its wide substrate scope, good functional group tolerance, operationally simple, and gram-scale reaction. Mechanism studies suggest that a radical pathway might be involved in current reaction.
Key words: visible-light, 2-benzylaminobenzamides, 4(3H)-quinazolinones


PDF全文下载地址:

点我下载PDF