摘要/Abstract

烯丙基胺化合物是有机合成化学和药物化学的重要化合物之一, 其合成方法备受关注. 以芳酰氧基氨基甲酸酯为原料通过分子内脱羧一步合成了烯丙基胺化合物, 而原料芳酰氧基氨基甲酸酯可由廉价易得的羧酸和羟胺原位制备. 反应条件温和, 底物普适性好, 并且可以实现克级和吲哚的合成.
关键词: 钯催化, 芳氧酰氨基甲酸酯, 脱羧, 烯丙基胺化, 烯丙胺
Allylamine compounds are one of the important compounds in organic synthetic chemistry and pharmaceutical chemistry, the synthetic methods of which are concerned. Using aroyloxycarbamates as start material, which was prepared in situ by cheap and easy-available carboxylic acid and hydroxylamine, allylamine compounds were synthesized by decarboxylation in one step. The reaction conditions are mild and the substrate is generally applicable. Moreover, the reaction realized the synthesis of indole.
Key words: palladium-catalysis, aroyloxycarbamate, decarboxylation, allylic amination, allylamine


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