摘要/Abstract

报道了在不同醇中无配体条件下钯催化二苯基H-亚膦酸酯对内炔的氢膦酰化反应合成E-烯烃膦酸酯类化合物的方法. 这种实用且通用的三组分反应涉及二苯基H-亚膦酸酯对相对惰性内炔的顺式加成, 以及伴随的二苯基H-亚膦酸酯的酯交换过程. 反应具有高立体选择性、宽泛的底物范围和无需额外配体等显著特点.
关键词: 加成反应, 三组分反应, 乙烯基膦酸酯, 钯, 内炔
A ligand-free Pd-catalyzed hydrophosphorylation of internal alkynes with diphenyl H-phosphonate in various alcohols for the synthesis of E-vinylphosphonates has been reported. This pratical and versatile three-component reaction involves the syn-addition of diphenyl H-phosphonate towards relatively inactive internal alkynes, as well as the concomitant transesterification of diphenyl H-phosphonate. The remarkable features include high stereoselectivity, wide substrate scope and the absence of additional ligands.
Key words: addition reaction, three-component reaction, vinylphosphonate, palladium, internal alkyne


PDF全文下载地址:

点我下载PDF