摘要/Abstract

报道了通过C—C键断裂开环构建环庚酮化合物的有效策略. 反应在碳酸铯存在下进行, 无需使用任何金属和氧化剂, 具有原料易得、底物适用性良好、反应条件温和的优点. 这种无金属催化炔插入C—Cσ-键, 通过分子内亲核加成/开环反应构建环庚酮化合物的方法, 在有机合成化学中有着广泛的应用前景。
关键词: C—C键断裂, 碱促进, 扩环, 环庚酮化合物
An efficient ring expansion strategy has been developed for the construction of cycloheptanones through C—C bond cleavage. The reactions take place with easily accessible starting materials, good functional group tolerance, and mild reaction conditions in the presence of Cs₂CO₃ without any metal or oxidant reagent. The transition-metal free insertions of alkynes into carbon-carbon σ-bonds of acenaphthenone initialized through intramolecular nucleophilic addition/ring-opening to furnish multifarious cycloheptanones, which has the potential to be widely utilized in organic synthetic chemistry.
Key words: C—C bond cleavage, ring expansion, base-promoted, cycloheptanone compounds


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