摘要/Abstract

从红树来源真菌Eupinillium sp. HJ002的发酵产物中分离获得一对新的差向异构体Eupenicilchromans A, B, 一个新的异香豆素衍生物eupenicillin A以及五个已知化合物. 通过多种波谱技术及电子圆二色谱(ECD)量子化学计算方法确定了新化合物的结构和绝对构型. Eupenicilchromans A, B显示强的抗氧化活性, IC₅₀值分别为0.6和2.6 mmol/L, Eupenicilchroman A的活性强于阳性对照药trolox (IC₅₀=1.6 mmol/L).
关键词: Eupenicillium sp, 异色原酮, 异香豆素, 抗氧化活性
A pair of novel isochroman epimers eupenicilchromans A, B, and one new isocoumarin derivative eupenicilmarin A, together with five known compounds were isolated from the culture of mangrove-derived fungusEupenicilium sp. HJ002. The structures of the new compounds, including the absolute configurations, were determined by comprehensive spectroscopic methods, experimental and calculated electronic circular dichroism (ECD) methods. Eupenicilchromans A, B showed potent antioxidant activeties with the IC₅₀ values of 0.6 and 2.6 mmol/L, respectively, and eupenicilchroman A displayed better antioxidant activity than the positive control trolox (IC₅₀=1.6 mmol/L).
Key words: Eupenicillium sp., isochroman, isocoumarin, antioxidant activity


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