摘要/Abstract
小檗碱(Berberine, BBR)是一种重要的天然药物, 是具有独特四环结构的异喹啉类生物碱. 近年来药理学研究发现, 小檗碱有望用于肿瘤及糖尿病等多发病的临床治疗. 结合Woodward等提出的生源合成理论, 综述了截至目前已报道的小檗碱的全合成策略与方法.
关键词: 天然药物, 小檗碱, 苄基异喹啉, 全合成
Berberine is an important natural drug and a kind of benzyl isoquinoline alkaloid, which has unique four-ring structure. In recent years, pharmacological research has found berberine is expected to be used in the clinical treatment of cancer, diabetes and other frequently occurring diseases. Based on the Woodward’s biosynthetic hypothesis, a schematic review on the synthetic studies towards berberine is provided.
Key words: natural drug, berberine, benzyl isoquinoline, total synthesis
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