摘要/Abstract
报道了一种基于Prins环化反应合成手性五元并七元氧桥环结构的方法, 为愈创木烷型倍半萜类天然产物骨架结构的合成提供了一种新思路. 该合成工作是以dioxinone为基础, 利用路易斯酸诱导发生分子内的Prins环化反应, 以两步72%的联合收率实现了手性[5,7]并环氧桥环的合成.
关键词: 愈创木烷, 手性氧桥七元环, Prins反应
A new method for the synthesis of chiral 5,7-fused oxygen bridged ring based on Prins cyclization is reported. It provides a new way for the synthesis of the skeleton structure of guaiacane sesquiterpenes. Based on dioxinone, the synthesis of chiral 5,7-fused oxygen bridged ring is achieved in a two-step combined yield of 72% by using Lewis acid induced intra- molecular Prins cyclization.
Result
Key words: guaiane, chiral oxygen bridge seven-membered ring, Prins reaction
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