摘要/Abstract
以3,4-二卤-2(5H)-呋喃酮、磺酰肼和羰基化合物为起始原料, 利用一锅法策略同时构建一个C—N键和一个 C=N键, 以良好收率合成一系列N-2(5H)-呋喃酮基磺酰腙类化合物. 这种无需金属催化的转化在室温下就可实现, 且具有好的底物适用性和选择性. 即使对于Csp2—Cl型的3,4-二氯-2(5H)-呋喃酮类底物, 这种绿色合成方法也能提供令人满意的产率. 重要的是, 这种方法对多个呋喃酮底物可实现克级反应制备.
关键词: 2(5H)-呋喃酮, 磺酰腙, 合成, 一锅法反应, 无金属催化
An efficient approach for the construction of one C—N bond and one C=N bond based on sulfonyl hydrazides, 3,4-dihalo-2(5H)-furanones and carbonyl compounds via the one-pot strategy to provideN-2(5H)-furanonyl sulfonyl hydrazone products with good yields is described. This approach with wide substrate range and good selectivity can be achieved at room temperature by metal-free catalysts. Even for 3,4-dichloro-2(5H)-furanones, the inactive Csp2—Cl type compounds, this green method also gives satisfactory yields. Importantly, its application for a gram-scale preparation of different furanone substrates can be accomplished.
Key words: 2(5H)-furanone, sulfonyl hydrazone, synthesis, one-pot reaction, metal-free catalysis
PDF全文下载地址:
点我下载PDF
