摘要/Abstract

采用溶剂提取法, Diaion HP-20、Sephadex LH-20葡聚糖凝胶、硅胶及制备高效液相等色谱方法, 对毛华菊的化学成分进行分离纯化, 并利用现代波谱技术对已分离得到的化合物进行结构鉴定. 从毛华菊的氯仿部位分离得到4个新化合物, 其结构类型属于愈创木内酯衍生物, 分别命名为(1S,5R,6S,7S,10S)-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(1)、(1S,5R,6R,7R,8S,10S)-8-异丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(2)、(1S,5R,6R,7R,8S,10S)-8-(2'-甲基)丁酰氧基-愈创木-3,11(13)-二烯-2-酮-12,6-内酯(3)和(1R,5R,6R,7R,8S,10S,11S)-8-乙酰氧基-愈创木-3-烯-2-酮-12,6-内酯(4), 以及2个已知化合物matricarin (5)和11,13-dehydromatricarin (6).
关键词: 毛华菊, 倍半萜内酯, 愈创木内酯
The chemical constituents fromDendranthema vestitum(Hemsl.) Ling were isolated and purified by solvent extraction, Diaion HP-20, Sephadex LH-20, silica gel and preparative high performance liquid chromatography. Their structures were elucidated based on their spectroscopic data. Four new compounds which belong to guaianolide, named as (1S,5R,6S, 7S,10S)-2-oxo-guaia-3,11(13)-dien-12,6-olide (1), (1S,5R,6R,7R,8S,10S)-2-oxo-8-isobutyryloxy-guaia-3,11(13)-dien-12,6-oli- de (2), (1S,5R,6R,7R,8S,10S)-2-oxo-8-(2'-methyl)butyryloxy-guaia-3,11(13)-dien-12,6-olide (3) and (1R,5R,6R,7R,8S,10S, 11S)-2-oxo-8-acetoxy-guaia-3-en-12,6-olide (4) together with two known compounds matricarin (5) and 11,13-dehydromatricarin (6) were isolated from chloroform extract ofDendranthema vestitum(Hemsl.) Ling.
Key words: Dendranthema vestitum(Hemsl.) Ling, sesquiterpene lactones, guaianolide


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