摘要/Abstract

报道一种简便高效地将亚砜脱氧还原的方法. 在100 ℃条件下, 无需外加溶剂, 一系列脂肪和芳香亚砜可与二甲氨基硫代甲酰氯反应, 以中等到优异的产率生成相应的产物硫醚. 该反应可以兼容多种官能团, 并且适合克级规模合成. 反应可能经过硫代亚砜中间体的生成和分解成硫醚和硫单质的过程.
关键词: 亚砜, 硫醚, 脱氧, 还原, 硫代
A simple and effective method of sulfoxide deoxidation is reported. Without any additional solvent, a series of aliphatic and aromatic sulfoxides could react with dimethylthiocarbamoyl chloride at 100 ℃ to afford the corresponding thioethers in moderate to excellent yields. This reaction is compatible with a number of functional groups and is suitable for gram-scale synthesis. A mechanism involving the formation of a thiosulfoxide intermediate and its degradation to thioether and elemental sulfur is proposed for the reaction.
Key words: sulfoxide, thioether, deoxygenation, reduction, thionation


PDF全文下载地址:

点我下载PDF