摘要/Abstract

过渡金属催化的导向C—H键活化反应具有反应效率高、选择性好、原子经济等优点, 特别是卡宾前体参与的 C—H活化反应已经发展为一种新颖的构筑碳碳键的合成策略. 相比于传统的重氮化合物等卡宾前体, 亚砜叶立德作为一种新型的卡宾前体, 具有易于制备、性质稳定、操作安全等诸多优点, 被广泛应用于C—H活化反应, 可以便捷地转化成各种酰甲基化或环化产物. 综述了近几年来亚砜叶立德在C—H键活化反应中的应用研究进展, 并对其今后的发展趋势进行了展望.
关键词: 过渡金属, C—H活化, 卡宾前体, 亚砜叶立德
Transition-metal-catalyzed chelation-assisted C—H functionalization has been increasingly explored as an efficient and atom-economical strategy for construction of C—C bonds. In particular, employing the carbene synthons as a coupling partner in C—H activation has been significantly developed. Compared with the traditional carbene precursors such as diazo compounds, sulfoxonium ylides are easier to synthesize and safer in reaction, which can be employed as practical alternatives in metal-carbene reactions. Recently, the coupling reactions of sulfoxonium ylides with organometallic intermediates, generated via C—H bond activation, have been reported. They have served as privileged synthetic skeletons to accessortho-C—H acylmethylated or cyclized compounds. The recent progress on the application of sulfoxonium ylides in C—H activation is summarized and the future research direction is prospect.
Key words: transition-metal, C—H activation, carbene precursor, sulfoxonium ylide


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