摘要/Abstract

发现了一种合成β-卟啉基-α，β-不饱和酮化合物的简便方法.在碱催化条件下以β-卟啉甲醛和酮为底物，通过Aldol反应合成了β-卟啉基-α，β-不饱和酮化合物，其反应特点包括无溶剂、条件温和、中等到较高的收率等.本方法特别适用于在已有报道中反应效果很差的常见的金属化卟啉底物，反应结果优良.
关键词: 金属卟啉, α,β-不饱和酮, Aldol反应, 无溶剂
A convenient approach for the synthesis of β-substituted α,β-unsaturated carbonyl porphyrin compounds via base-catalyzed aldol reaction was developed. By this method, a series of β-substituted α,β-unsaturated carbonyl porphyrin compounds were constructed using β-porphyrin formaldehyde and ketones with moderate to excellent yields under mild reaction conditions, especially solvent-free, and good functional group tolerance. Furthermore, this process was successfully applied to the reactions of different metal porphyrin which have been reported to have poor reaction effects with good yields.
Key words: metal porphyrin, α,β-unsaturated carbonyl, aldol reaction, solvent-free


PDF全文下载地址:

点我下载PDF