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铜催化肟酯参与的[3+3]环加成反应合成4-五氟乙基取代的吡啶类化合物

本站小编 Free考研考试/2022-02-14

摘要/Abstract



报道了一种铜催化肟酯与β-五氟乙基取代的α,β-不饱和酮的[3+3]环加成反应,实现了4-五氟乙基取代的吡啶类化合物的合成.反应具有操作简便、原料易得等优点,有较好的底物适用性以及优秀的区域选择性.反应机理也进行了初步研究.
关键词: 五氟乙基, 吡啶, 铜催化, 肟脂
An improved method for the synthesis of pentafluoroethylated pyridines through Cu-catalyzed[3+3] cyclo-addition reaction of oxime acetates is reported. The starting materials are more readily available, and these reactions occurred under mild conditions with broad substrate scope and excellent regioselectivity. Mechanistic studies have also been preformed.
Key words: pentafluoroethylated, pyridines, copper-catalyzed, oxime acetates


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相关话题/优秀 乙基 吡啶 不饱和 适用性

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