摘要/Abstract

N-烯丙基芳胺在非金属催化条件下，发生多氯甲基化/环化串联反应生成多氯甲基取代的吲哚啉.该反应以非活化的烯烃为自由基受体，过氧化二异丙苯（DCP）为引发剂，廉价的二氯甲烷、氯仿、四氯化碳溶剂作为二氯甲基化或三氯甲基化试剂，且具有操作简单、条件温和、成本低、底物适用范围广等优点.
关键词: 非活化烯烃, 多氯甲基化, 吲哚啉, 自由基反应
A metal-free polychloromethylation/cyclization cascade of N-allyl anlines is presented, which provides an access to polychloromethyl-substituted indolines with unactivated alkenes as radical acceptors and dicumyl peroxide (DCP) as the initiator. The inexpensive solvents of polychoromethanes (i.e., CH₂Cl₂, CHCl₃ and CCl₄) were used in the reaction as di-or trichloromethylating agents. This work has advantages of easy operation, mild conditions, low cost, and broad substrate scope.
Key words: unactivated alkenes, polychloromethylation, indolines, radical reaction


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