摘要/Abstract

合成了一系列新型硫脲-酰胺有机小分子催化剂，将该类催化剂应用于2，4-戊二酮对各种取代硝基烯烃的不对称Michael加成反应中，在1 mol%催化剂用量情况下，以较高的产率和优异的对映选择性（最高94%ee）得到了加成产物.该催化体系具有广泛的适应性，能够适合含有吸电子和供电子基团的各种硝基烯烃的不对称加成.初步的构效关系研究表明，吡咯烷N-酰基结构单元在催化反应中起到重要作用.
关键词: 硫脲-酰胺, 有机小分子催化剂, Michael加成, 不对称
New bifunctional chiral thiourea-amide organocatalysts were developed. Their applications in asymmetric conjugate addition of 2,4-pentandione to various nitroalkenes were investigated. The corresponding adducts were obtained in excellent yields with high enantioselectivities up to 94% ee in present of 1 mol% catalyst. The catalytic system could also suit for various nitroalkenes bearing electron-donating or electron-withdrawing groups. The preliminary structure-activity relationship study reveals that the acyl group in pyrrolidine N position plays an important role in catalyzing the reaction.
Key words: thiourea-amide, organocatalyst, Michael addition, asymmetric


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