摘要/Abstract

喹喔啉-2（1H）-酮是天然产物和药物中存在的一种非常重要的N-杂环化合物，具有广泛的生物活性.近年来，研究者对喹喔啉-2（1H）-酮的C-H键活化和功能化的进行了大量的研究，包括烷基化、苄基化、酰化、芳基化、胺化、酰胺化、膦酰化、氟烷基化等.综述了近年来该领域的研究进展，并对其反应机理进行了探讨.
关键词: 喹喔啉-2(1H)-酮, C-H键活化, 功能化, 过渡金属催化
Quinoxalin-2(1H)-ones are very important N-heterocyclic moieties found in natural products and pharmaceuticals, and exhibit an amazingly wide spectrum of biological properties. Numerous efforts have been devoted to the development of efficient approaches for the C-H bond activation and functionalization of quinoxalin-2(1H)-ones in recent years, including alkylation, benzylation, acylation, arylation,amination, amidation, phosphonation, and fluoroalkylation. The recent advances in this area are summarized and their reaction mechanisms are discussed.
Key words: quinoxalin-2(1H)-one, C-H bond activation, functionalization, transition-metal catalyst


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