摘要/Abstract

2-取代-1，2，3，4-四氢喹啉骨架广泛存在于天然产物中，具有抗疟、抗氧化等生物活性.报道了MIL-101（Cr）-SO₃H催化以汉奇酯为氢供体的2-取代喹啉衍生物的转移氢化反应.该方法反应条件温和，适用于2位具有不同取代基的喹啉衍生物，催化剂易于回收和循环利用，为2-取代-1，2，3，4-四氢喹啉衍生物的合成提供了新途径.
关键词: 汉奇酯, 多相催化, 氢转移, MIL-101(Cr)-SO₃H, 1,2,3,4-四氢喹啉衍生物
The 2-substituted-1,2,3,4-tetrahydroquinoline skeletons are widely found in natural products and have shown antimalarial, antioxidant as well as other biological activities. In this work, MIL-101(Cr)-SO₃H is an efficient heterogeneous catalyst for the transfer hydrogenation of a series of 2-substituted quinoline derivatives with Hantzsch ester as the hydrogen source. This protocol operates under mild conditions, tolerates a wide range of 2-substituted quinoline derivatives, and the catalyst could be recovered and reused four times without considerable loss of catalytic activities, which provides a new catalytic system for the construction of 2-substituted-1,2,3,4-tetrahydroquinoline derivatives.
Key words: Hantzsch ester, heterogeneous catalysis, hydrogen transfer, MIL-101(Cr)-SO₃H, 1,2,3,4-tetrahydroquinolines


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