摘要/Abstract

发展了一种吡唑基导向的钌催化的1-苄基-1H-吡唑与烯烃或a，β-不饱和酮的C（sp²）-H键烯基化和烷基化反应.该反应具有较好的选择性，烯基化和烷基化选择性地发生在苄基的邻位.为1-苄基-1H-吡唑的官能团化提供了一种有效方法.
关键词: 1-苄基-1H-吡唑, 烯基化, 烷基化, C(sp²)-H键
A practical ruthenium-catalyzed C(sp²)-H alkenylation and alkylation of 1-benzyl-1H-pyrazole with alkene or a,β-unsaturated ketones under the assistance of pyrazole group were developed. This method has the advantages of high selectivity, providing only the ortho-alkenylation or ortho-alkylation products in high yields. This protocol provides an efficient and new method for the functionalization of 1-benzyl-1H-pyrazoles.
Key words: 1-benzyl-1H-pyrazole, alkenylation, alkylation, C(sp²)-H bond


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