摘要/Abstract

烯烃的不对称氢甲酰化反应是合成手性醛的重要方法之一.近年来，不对称氢甲酰化反应研究取得了重要进展，发展了一系列适用于不对称氢甲酰化的新配体，实现了几类重要烯烃的不对称氢甲酰化反应，为手性醛的合成提供了简单高效的方法.介绍了不对称氢甲酰化研究的新进展，重点对几类代表性底物的不对称氢甲酰化反应以及相关配体进行了总结.
关键词: 烯烃, 不对称氢甲酰化, 醛, 手性膦配体, 铑
Asymmetric hydroformylation is one of the most important reactions for preparation of chiral aldehydes from alkenes. Recently, significant progress has been made in this field and a series of new ligands have been developed. Asymmetric hydroformylation of several important alkenes has been achieved, offering efficient and concise methods for the synthesis of chiral aldehydes. In this review, the achievements of asymmetric hydroformylation of typical alkenes and the development of ligands for asymmetric hydroformylation are summarized.
Key words: alkene, asymmetric hydroformylation, aldehyde, chiral phosphine ligand, rhodium


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