摘要/Abstract

以廉价易得的亚硝酸钠为硝基来源，N，O-双齿配体为导向基团，实现了一种廉价铜盐催化的芳烃C-H键的直接硝基化反应.该反应对绝大多数酰胺底物容忍性好，并以中等至良好的收率得到相应的硝基羧酸衍生物，为芳香硝基化合物的合成提供了一种廉价、易操作的方法.
关键词: C-H键活化, 双齿导向, 铜催化, 硝基化
Cu(Ⅱ)-promoted C-H nitration of arenes has been disclosed with the aid of N,O-bidentate directing group. The protocol was operationally simple by using NaNO₂as the nitration source. Various amide substrates were tolerated in the reaction system, which establishes opportunities for developing simple and facile methods, and enriches the strategies to access aromatic nitro derivatives.
Key words: C-H activation, bidentate direction, Cu-catalyzed, nitration


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