Professor CHENG Chun-yiu, Jack 郑振耀
MD(CUHK), MBBS(HKU), FRCS(Edin), FRCS Ortho(Edin), FHKCS, FHKCOS, FHKAM(Ortho Surg)
Emeritus Professor of Orthopaedics and Traumatology
矫形外科及创伤学系荣休教授

BIOGRAPHY
Professor Cheng is the Emeritus Professor of the Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong. After graduated with MB BS degree from the University of Hong Kong in 1976, he was awarded the Commonwealth Medical Fellowships to further study and training in orthopaedics at the University of Oxford and the University of Edinburgh in 1982-83 He was awarded the degree of Doctor of Medicine (with merits) by The Chinese University of Hong Kong in 1999.
Professor Cheng joined The Chinese University of Hong Kong in 1983 and had served as Chairman of the Department of Orthopaedics and Traumatology, Sub-Dean (Medical Education) and Associate Dean (Education) of the Faculty of Medicine, University Dean of Students and Pro-Vice-Chancellor (2002-2012). He has served as member of University Grants Committee (2007-13) and lately as member of the Research Grant Council (2013-16).
Professor Cheng is a paediatric orthopaedics specialist with special research interests in the etiopathogenesis of adolescent idiopathic scoliosis, congenital muscular torticollis, bone mineral and bone health research and biomaterial basic science and applied studies. He is Co-Director of the Joint Scoliosis Research Centre of The Chinese University of Hong Kong and Nanjing University.
Professor Cheng has published over 360 publications in peer-reviewed international journals, over 500 conference presentations, contributed to 19 book chapters and received more than 30 research related awards. He serves on the editorial boards of a number of international professional journals. He was president of the Hong Kong Orthopaedic Association and fellow and member of over 20 local and prestigious international professional and medical organisations including the POSNA, SRS, IPOTT, IFPOS, IRSSD, APOA.

CLINICAL EXPERTISE Paediatric Orthopaedics
Scoliosis

SPECIALISED RESEARCH AREAS Etiopathogenesis and Imaging of Adolescent Idiopathic Scoliosis
Bone Health and Related Research

SELECTED PUBLICATION
1. Liu H, Liu Z, Man CW, Guo J, Han X, Hu Z, Ng TB, Zhao Z, Li J, Wang W, Chun TC, Qiao J, Shi B, Xu L, Bao H, Jiang Q, Lam TP, Cheng JCY*, Qiu Y, Zhu Z. (2019) The effect of exogenous melatonin on reducing scoliotic curvature and improving bone quality in melatonin-deficient C57BL/6J mice. Scientific reports 9 (1):6202. doi:10.1038/s41598-019-42467-5.

2. Li X, Hung VWY, Yu FWP, Hung ALH, Ng BKW, Cheng JCY*, Lam TP, Yip BHK. (2019) Persistent low-normal bone mineral density in adolescent idiopathic scoliosis with different curve severity: A longitudinal study from presentation to beyond skeletal maturity and peak bone mass. Bone:115217. doi:10.1016/j.bone.2019.115217.

3. Chen H, Zhang J, Wang Y, Cheuk KY, Hung ALH, Lam TP, Qiu Y, Feng JQ, Lee WYW, Cheng JCY*. (2019) Abnormal lacuno-canalicular network and negative correlation between serum osteocalcin and Cobb angle indicate abnormal osteocyte function in adolescent idiopathic scoliosis. FASEB J:fj201901227R. doi:10.1096/fj.201901227R.

4. Zhu TY, Yip BHK, Hung VWY, Choy CWY, Cheng KL, Kwok TCY, Cheng JCY*, Qin L. (2018) Normative Standards for HRpQCT Parameters in Chinese Men and Women. J Bone Miner Res. doi:10.1002/jbmr.3481.

5. Cheuk KY, Wang XF, Wang J, Zhang Z, Yu FWP, Tam EMS, Hung VWY, Lee WYW., Ghasem-Zadeh A., Zebaze R, Zhu TY, Guo XE, Cheng JCY*, Lam TP, Seeman E. (2018) Sexual Dimorphism in Cortical and Trabecular Bone Microstructure Appears During Puberty in Chinese Children. J Bone Mineral Research. 33(11):1948-1955.

6. Zhang JJ, Chen HX, Leung RKK, Choy KW, Lam TP, Ng BKW, Qiu Y, Feng JQ, Cheng JCY*, Lee WY. (2018) Aberrant miR-145-5p/β-catenin signal impairs osteocyte function in adolescent idiopathic scoliosis. FASEB. 32(12):6537-6549.

7. Hung ALH, Shi BL, Chow SKH, Chau WW, Hung VWY, Wong RMY, Liu KL, Lam TP, Ng BKW, Cheng JCY*. (2018) Validation Study of the Thumb Ossification Composite Index (TOCI) in Idiopathic Scoliosis – a stage to stage correlation with Classic Tanner-Whitehouse and Sanders Simplified Skeletal Maturity Systems. J Bone Joint Surg Am. 100(13):e88:1-9.

8. Hung ALK; Chau WW; Shi B; Chow SK; Yu FYP; Lam TP; Ng BKW; Qiu Y; Cheng JCY*. (2017) Thumb Ossification Composite Index (TOCI) for Predicting Peripubertal Skeletal Maturity and Peak Height Velocity in Idiopathic Scoliosis- A Validation Study of Premenarchal Girls with Adolescent Idiopathic Scoliosis Followed Longitudinally Until Skeletal Maturity. J Bone Joint Surg Am. 99:1438-46.

9. Yip BHK; Yu FWP; Wang ZW; Hung VWY; Lam TP; Ng BKW; Zhu F and Cheng JCY*. (2016) Prognostic Value of Bone Mineral Density on Curve Progression: A Longitudinal Cohort Study of 513 Girls with Adolescent Idiopathic Scoliosis. Scientific Reports 6, Article: 39220.

10. Zhu Z; Tang NLS; Xu L; Qin X; Mao S; Song Y; Liu L; Li F; Liu P; Yi L; Chang J; Jiang L; Ng BKW; Shi B; Zhang W; Qiao J; Sun X; Qiu X; Wang Z; Wang F; Xie D; Chen L; Chen Z; Jin M; Han X; Hu Z; Zhang Z; Liu Z; Zhu F; Qian BP; Yu Y; Wang B; Lee KM; Lee WYW; Lam TP; Qiu Y and Cheng JCY*. (2015) Genome-wide association study identifies new susceptibility loci for adolescent idiopathic scoliosis in Chinese girls. Nat Commun. 6: 8355.

11. Cheng JCY*; Castelein RM; Chu WCW; Danielsson AJ; Dobbs MB; Grivas TB; Gurnett CA; Luk KD; Moreau A; Newton PO; Stokes IA; Weinstein SL and Burwell RG. (2015) Adolescent idiopathic scoliosis. Nature Reviews Disease Primers. 15030.

12. Yu WS; Chan KY; Yu FWP; Ng BKW; Lee KM, Qin L; Lam TP; and Cheng JCY*. Bone structural and mechanical indices in Adolescent Idiopathic Scoliosis evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT). Bone. 2014; 61: pp.109-15.

13. Londono D; Kou I; Johnson TA; Sharma S; Ogura Y; Tsunoda T; Takahashi A; Matsumoto M; Herring JA; Lam TP; Wang X; Tam EM; Song YQ; Fan YH; Chan D; Cheah KS; Qiu X; Jiang H; Huang D; Group TIC; International Consortium for Scoliosis G; Su P; Sham P; Cheung KM; Luk KD; Gordon D; Qiu Y; Cheng JCY*; Tang N; Ikegawa S and Wise CA. (2014) A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. J Medical Genetics. 51(6): 401-6.

14. Yu WS; Chan KY; Yu FWP; Yeung HY; Ng BK; Lee KM; Lam TP; Cheng JCY*. Abnormal bone quality versus low bone mineral density in adolescent idiopathic scoliosis: a case-control study with in vivo high-resolution peripheral quantitative computed tomography. The Spine Journal. 2013; 13(11): pp.1493-9.

15. Lam TP, Hung VW, Yeung HY, Tse YK, Chu WC, Ng BK, Lee KM, Qin L and Cheng JCY*. Abnormal bone quality in adolescent idiopathic scoliosis: a case-control study on 635 subjects and 269 normal controls with bone densitometry and quantitative ultrasound. Spine (Phila Pa 1976). 2011;36(15):1211-7.

16. Man GC, Wang WW, Yeung BH, Lee SK, Ng BK, Hung WY, Wong JH, Ng TB, Qiu Y and Cheng JCY*. Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin. J Pineal Res. 2010;49(1):69-77.

17. Weinstein SL, Dolan LA, Cheng JCY*, Danielsson A and Morcuende JA. Adolescent idiopathic scoliosis. Lancet. 2008;371(9623):1527-1537.

18. Lee WT, Cheung CS, Tse YK, Guo X, Qin L, Lam TP, Ng BK and Cheng JCY*. Association of osteopenia with curve severity in adolescent idiopathic scoliosis: a study of 919 girls. Osteoporos Int. 2005;16(12):1924-32.

19. Hung VW, Qin L, Cheung CS, Lam TP, Ng BK, Tse YK, Guo X, Lee KM and Cheng JCY*. Osteopenia: A new prognostic factor of curve progression in adolescent idiopathic scoliosis. J Bone Joint Surg Am. 2005;87:2709-16.

























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