Professor CHOW Kwoon-Ho, Simon 周冠豪
BSc(University of Toronto), MSc(CUHK), PhD(CUHK)
Research Assistant Professor of Orthopaedics and Traumatology
矫形外科及创伤学系研究助理教授

BIOGRAPHY
Professor Simon Chow is a human biologist by training from the University of Toronto (2002). He joined the Department of Orthopaedics and Traumatology in 2005 and pursued further training and obtained his MSc in Biomedical Engineering in 2009 and subsequently his PhD in Orthopaedics and Traumatology in 2014.
His research focuses on tackling musculoskeletal ageing problems. Fragility fracture is highly associated with sarcopenia and fall. His bench side research include the biology and the enhancement of osteoporotic fracture healing by mechanical stimulation; the impairment and restoration of inflammatory response during the fracture healing process; the application of bio-functionalized 3D printed metal implants for osteoporotic fracture healing; and nutritional and physical intervention to control the progression of sarcopenia. Furthermore, he is the coordinator of the Community Fall Prevention Campaign that is established since year 2000 carrying the mission to transfer the most updated musculoskeletal health knowledge directly to community older people. He is member of the Orthopaedics Research Society (USA) and International Section of Fracture Repair (ISFR); member of the Society of Sarcopenia, Cachexia and Wasting Disorders (SCWD, Germany); and member of the Editorial Review Board of the Journal of Orthopaedic Research (JOR, USA). Professor Chow has published over 30 articles in international peer-reviewed journal articles, over 50 conference abstracts, 3 book chapters and successful track records in attracting competitive external research funding.
On the technical side, Simon Chow has over 15 year of research experience in orthopaedics and traumatology. He is the technical specialist and the manager of the pre-clinical MicroCT laboratory, the coordinating officer of the department postgraduate training workshop and animal experimentation.

EXPERTISE Animal Experimentation
Bone Densitometry
MicroCT in Orthopaedic Research

SPECIALISED RESEARCH AREAS Mechanobiology of Fracture Healing
Sarcopenia & Muscle-bone Interaction
Community Fall Prevention
Clinical Application of 3D Printing


SELECTED PUBLICATION
1. Wei FY, Chow SK*, Leung KS, Qin J, Guo A, Yu OL, Li G, Cheung WH (2016) Low-magnitude high-frequency vibration enhanced mesenchymal stem cell recruitment in osteoporotic fracture healing through the SDF-1/CXCR4 pathway. European cells & materials 31:341-354.

2. Chow SK*, Leung KS, Qin J, Guo A, Sun M, Qin L, Cheung WH (2016) Mechanical stimulation enhanced estrogen receptor expression and callus formation in diaphyseal long bone fracture healing in ovariectomy-induced osteoporotic rats. Osteoporos Int.

3. Guo AY, Leung KS, Siu PM, Qin JH, Chow SK*, Qin L, Li CY, Cheung WH (2015) Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8). Experimental animals / Japanese Association for Laboratory Animal Science 64:425-433.

4. Guo AY, Leung KS, Qin JH, Chow SK*, Cheung WH (2015) Effect of Low-Magnitude High-Frequency Vibration Treatment on Retardation of Sarcopenia - Senescence Accelerated Mice-P8 (SAMP8) Model. Rejuvenation research.

5. An Yun G, Leung KS, Siu PM, Qin JH, Chow SK*, Qin L, Li CY, Cheung WH (2015) Muscle mass, structural and functional investigations of senescence-accelerated mouse P8 (SAMP8). Experimental animals / Japanese Association for Laboratory Animal Science 64:425-433.

6. Wei FY, Leung KS, Li G, Qin J, Chow SK*, Huang S, Sun MH, Qin L, Cheung WH (2014) Low intensity pulsed ultrasound enhanced mesenchymal stem cell recruitment through stromal derived factor-1 signaling in fracture healing. PLoS One 9:e106722.

7. Qin J, Chow SK*, Guo A, Wong WN, Leung KS, Cheung WH (2014) Low magnitude high frequency vibration accelerated cartilage degeneration but improved epiphyseal bone formation in anterior cruciate ligament transect induced osteoarthritis rat model. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 22:1061-1067.

8. Chow SK*, Leung KS, Qin L, Wei F, Cheung WH (2014) Callus formation is related to the expression ratios of estrogen receptors-alpha and -beta in ovariectomy-induced osteoporotic fracture healing. Arch Orthop Trauma Surg 134:1405-1416.

9. Sun MH, Leung KS, Zheng YP, Huang YP, Wang LK, Qin L, Leung AH, Chow SK*, Cheung WH (2012) Three-dimensional high frequency power Doppler ultrasonography for the assessment of microvasculature during fracture healing in a rat model. J Orthop Res 30:137-143.

10. Chow SK*, Lee KM, Qin L, Leung KS, Cheung WH (2011) Restoration of longitudinal growth by bioengineered cartilage pellet in physeal injury is not affected by low intensity pulsed ultrasound. J Biomed Mater Res B Appl Biomater 99:36-44.

























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