Professor LIN Sien 林思恩
Bachelor of Clinical Medicine (GDMU), Master of Medicine (GDMU), PhD (CUHK)
Research Assistant Professor of Orthopaedics and Traumatology
矫形外科及创伤学系研究助理教授

BIOGRAPHY
Professor Lin obtained his medical degrees from the Guangdong Medical University (GDMU) and his PhD in Orthopaedics and Traumatology from CUHK in 2015. He pursued his postdoctoral training in the Department of Orthopaedics and Traumatology of CUHK (2016-2019) and in the Department of Orthopaedic Surgery at Stanford University (2019-2021). He has published over 60 publications in peer-reviewed international journals (H-index 25) and serves as a guest editor of Frontiers in Pharmacology and Journal of Orthopaedic Translation and as a reviewer of several international journals, including Biomaterials, Stem Cell Research & Therapy, and Materials Science & Engineering C. Professor Lin is a member of the Orthopaedic Research Society (ORS) and the International Chinese Musculoskeletal Research Society (ICMRS). He also serves as a member of the Clinical Research Committee and as an adjunct professor of Orthopaedic Surgery in the Affiliated Hospital of Guangdong Medical University, China.
Professor Lin is passionate about the research and development (R&D) of regenerative strategies for traumatic cartilage and bone defects and novel therapeutic strategies for osteoarthritis and osteoporosis. His work focuses on using biological approaches to achieve functional cartilage regeneration through stem cell therapeutics and biomimetic hydrogels. Professor Lin also specializes in bone tissue engineering using 3D printed porous scaffolds, porous hydrogels, stem cells, and the distraction osteogenesis technique to promote bone defect healing. Within the field of tissue engineering, his work has been published in Biomaterials, Osteoarthritis Cartilage, Stem Cell Research & Therapy, Science Advances, etc. His research in tissue engineering was funded by the National Natural Science Foundation of China (NSFC). Outside of the field of tissue engineering, Professor Lin has also worked on the R&D of bioactive small molecules derived from Traditional Chinese Medicine (TCM) for the treatment of osteoarthritis and osteoporosis. In this field, his work has been published in Calcified Tissue International, European Journal of Pharmacology, Journal of Orthopaedic Translation, etc. His work in TCM has been funded by the General Research Fund (GRF, Co-I) and the Health and Medical Research Fund (HMRF, Co-I). Professor Lin was a recipient of the Student and Young Investigator Award (Tissue Engineering and Regenerative Medicine International Society, TERMIS) and Best Poster awards in academic meetings held by ORS, ICMRS, and CUHK.

EXPERTISE Musculoskeletal Tissue Engineering
Stem Cell Therapy
Distraction Osteogenesis
Bone Histomorphometry

SPECIALISED RESEARCH AREAS Biomimetic Hydrogel or Porous Scaffolds for Cartilage or Bone Regeneration
Lineage Commitment of Stem Cell Differentiation for Therapeutic Applications
Small Molecules in TCM for the Treatment of Bone or Cartilage Degeneration


SELECTED PUBLICATION
1. Pan Q, Li Y, Li Y, Wang H, Kong L, Yang Z, Zhang X, Bai S, Zong Z, Chen G, Lin S*, Li G. Local administration of allogeneic or autologous bone marrow derived mesenchymal stem cells enhanced bone formation similarly in distraction osteogenesis. Cytotherapy, 2021;S1465-3249(20)30985-3. (IF: 4.2)

2. Zong Z, Zhang X, Yang Z, Yuan W, Huang J, Lin W, Chen T, Yu J, Chen J, Cui L, Li G, Wei B, Lin S*. Rejuvenated aging mesenchymal stem cells by stepwise preconditioning ameliorates surgery-induced osteoarthritis in rabbits. Bone Joint Res, 2021;10(1):10-21. (IF: 3.5)

3. Yang Y, Pan Q, Zou K, Wang H, Zhang X, Yang Z, Lee YW, Wei B, Gu W, Yang YP, Lin S*, Li G. Administration of allogeneic mesenchymal stem cells in lengthening phase accelerates early bone consolidation in rat distraction osteogenesis model. Stem Cell Res & Ther, 2020; 11(1):129. (IF: 5.1)

4. Huang J, Wang H, Huang M, Zong Z, Wu X, Xu J, Lan H, Zheng J, Zhang X, Lee YW, Wei B, Cui L, Li G, Lin S*. Asiatic Acid Attenuates Bone Loss by Regulating Osteoclastic Differentiation. Calcif Tissue Int. 2019; 105:531-545. (IF:3.3)

5. Xu J, Feng Q, Lin S*, Yuan W, Li R, Li J, Wei K, Chen X, Zhang K, Yang Y, Wu T, Wang B, Zhu M, Guo R, Li G, Bian L. Injectable stem cell-laden supramolecular hydrogels enhance in situ osteochondral regeneration via the sustained co-delivery of hydrophilic and hydrophobic chondrogenic molecules. Biomaterials. 2019;210:51-61. (IF:10.3)

6. Lin S*, Cui L, Chen G, Huang J, Yang Y, Zou K, Lai Y, Wang X, Zou L, Wu T, Cheng JCY, Li G, Wei B, Lee WYW. PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials. 2019;196:109-121. (IF:10.3)

7. Li R, Lin S*, Zhu M, Deng Y, Chen X, Wei K, Xu J, Li G, Bian L. Synthetic presentation of noncanonical Wnt5a motif promotes mechanosensing-dependent differentiation of stem cells and regeneration. Science Advances. 2019;5(10):eaaw3896. (IF:12.8)

8. Lin S*, Lee YW, Feng Q, Xu L, Wang B, Man CWG, Chen Y, Jiang X, Bian L, Cui L, Wei B, Li G. Synergistic Effects on Mesenchymal Stem Cell-based Cartilage Regeneration by Chondrogenic Preconditioning and Mechanical Stimulation. Stem Cell Res & Ther. 2017;8(1):221. (IF:4.9)

9. Lin S*, Lee YW, Xu L, Wang Y, Chen Y, Ho KW, Qin L, Jiang X, Cui L, Li G. Stepwise Preconditioning Enhances Mesenchymal Stem Cell-based Cartilage Regeneration through Epigenetic Modification. Osteoarthritis Cartilage. 2017; 25(9):1541-1550. (IF:5.5)

10. Lin S*, Huang J, Fu Z, Liang Y, Wu H, Xu L, Sun Y, Lee WY, Wu T, Qin L, Cui L, Li G. The effects of atorvastatin on the prevention of osteoporosis and dyslipidemia in the high-fat-fed ovariectomized rats. Calcif Tissue Int. 2015;96(6):541-51. (IF:3.3)

























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