Professor LEE Yuk-wai, Wayne 李郁伟
BSc(Hons, HKBU), PhD(CUHK)
Assistant Professor of Orthopaedics and Traumatology
矫形外科及创伤学系助理教授

BIOGRAPHY
Professor Lee obtained his PhD in Pharmacology from The Chinese University of Hong Kong in 2009, then pursued postdoctoral training in the Department of Orthopaedics and Traumatology of CUHK. He has published over 60 publications in peer-reviewed international journals (Scopus H-index 23), and serves as reviewers of a number of international journals.
His research can be divided into two major areas of orthopaedic with important clinical relevance. The first line focuses on the development of cell therapy to treat osteoarthritis and other musculoskeletal problems. His team also explore novel treatment strategies such as MSC secretome, miRNA and biomaterials with MSC tracking and controlled release properties. The second line is on the biological roles of osteocyte in adolescent idiopathic scoliosis. His team has developed advanced research platforms for the study of osteocyte, and recently established a composite model composed of circulating microRNA and bone turnover marker to predict curve progression.

SPECIALISED RESEARCH AREAS Etiopathogenesis of Adolescent Idiopathic Scoliosis
Stem Cell Biology and Clinical Application
Bone-Muscle Interaction
Pharmacology of Traditional Chinese Medicine


SELECTED PUBLICATION
1. S. Lin, L. Cui, G. Chen, J. Huang, Y. Yang, K. Zou, Y. Lai, X. Wang, L. Zou, T. Wu, J.C.Y. Cheng, G. Li, B. Wei, W.Y.W. Lee*, PLGA/β-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials, 196 (2019) 109-121 (IF: 10.273).

2. H. Chen, J. Zhang, Y. Wang, K.Y. Cheuk, A.L.H. Hung, T.P. Lam, Y. Qiu, J.Q. Feng, W.Y.W. Lee*, J.C.Y. Cheng, Abnormal lacuno-canalicular network and negative correlation between serum osteocalcin and Cobb angle indicate abnormal osteocyte function in adolescent idiopathic scoliosis. FASEB Journal, 33 (2019) 13882-13892 (IF: 5.391).

3. J. Zhang, H. Chen, R.K.K. Leung, K.W. Choy, T.P. Lam, B.K.W. Ng, Y. Qiu, J.Q. Feng, J.C.Y. Cheng, W.Y.W. Lee*. Aberrant miR-145-5p/beta-catenin signal impairs osteocyte function in adolescent idiopathic scoliosis. FASEB Journal, 32 (2018) 6537–6549 (IF: 5.391).

4. S. Lin, W.Y. Lee*, Q. Feng, L.L. Xu, B. Wang, G.C.W. Man, Y.F. Chen, X.H. Jiang, L.M. Bian, L. Cui, B. Wei, G. Li, Synergistic effects on mesenchymal stem cell-based cartilage regeneration by chondrogenic preconditioning and mechanical stimulation. Stem Cell Research & Therapy, 8 (2017) (IF: 4.627).

5. J.M. Li, W.Y.W. Lee*, T.Y. Wu, J.B. Xu, K.Y. Zhang, D.S.H. Wong, R. Li, G. Li, L.M. Bian, Near-infrared light-triggered release of small molecules for controlled differentiation and long-term tracking of stem cells in vivo using upconversion nanoparticles. Biomaterials, 110 (2016) 1-10 (IF: 10.273).

6. B. Wang, W.Y. Lee*, B. Huang, J. Zhang, T. Wu, X. Jiang, C.C. Wang, G. Li. Secretome of human fetal mesenchymal stem cell ameliorates replicative senescence. Stem Cells and Development, (2016) (IF: 3.147).

7. W.Y. Lee*, N. Li, S. Lin, B. Wang, H.Y. Lan, G. Li, miRNA-29b improves bone healing in mouse fracture model. Molecular and cellular endocrinology, 430 (2016) 97-107 (IF: 3.693).

8. T. Zhang, Y.W. Lee*, Y.F. Rui, T.Y. Cheng, X.H. Jiang, G. Li, Bone marrow-derived mesenchymal stem cells promote growth and angiogenesis of breast and prostate tumors. Stem Cell Research & Therapy, 4 (2013) (IF: 4.627).

9. W.Y. Lee*, T. Zhang, C.P. Lau, C.C. Wang, K.M. Chan, G. Li, Immortalized human fetal bone marrow-derived mesenchymal stromal cell expressing suicide gene for anti-tumor therapy in vitro and in vivo. Cytotherapy, 15 (2013) 1484-1497 (IF: 4.297).

10. W.Y. Lee*, P.P. Lui, Y.F. Rui. Hypoxia-mediated efficient expansion of human tendon-derived stem cells in vitro. Tissue Eng Part A, 18 (2012) 484-498 (IF: 3.616)

























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