Professor LUI Po-yee, Pauline 吕宝仪
Ph.D. in Biochemistry, PgDip in Clinical Trial Research Methodology, PgCert in Pharmacology and Pharmaceutical Management
Associate Professor of Orthopaedics and Traumatology
矫形外科及创伤学系副教授

BIOGRAPHY
Dr. Pauline Po-Yee LUI is a renowned research in the field of Orthopaedics Sports Medicine, particularly on tendons and ligaments. Her research interest includes tendon stem cells and their niches, tissue engineering and regenerative medicine, tendinopathy, anterior cruciate ligament reconstruction, tendon and ligament healing. She has published over 74 peer-reviewed papers and is the holder of two patents. She is one of the leading scientists in the field of tendon stem cells with many of her work being cited. Her H-index (Google scholar) is 40. Dr. Lui is internationally well-known for her work on tendon-derived stem cells (TDSCs) and tendinopathy. Her group published the first report on the isolation and characterization of tendon-derived stem cells in rat model and named the isolated cells 'TDSCs'. Her group was the first to introduce the concept and demonstrate the erroneous differentiation of TDSCs and mechanical-induced overexpression of chondro-osteogenic bone morphogenetic proteins (BMPs) as the pathogenic mechanisms of tendinopathy. The findings have laid the foundation for many studies in the field on the etiopathogenesis of tendinopathy. Her group has also successful localized the stem cells in tendon and characterized their niches in situ, which for the first time, has revealed the potential sources, identity and roles of these cells in situ. In this connection, she has obtained many research grants with a total funding of HKD$120.566 million from the University Grant Council and The Hong Kong Jockey Club Charities Trust, among others.
She is the editorial board members of 11 journals as well as reviewers of 62 journals. Because of her expertise in sports medicine, particularly on stem cells and regenerative medicine, as well as tendon and ligament injuries, she is frequently invited as the reviewer of manuscripts and grants on this topic. She is currently the external reviewer of the European Research Council and European Science Foundation. She has been the assessor of the Public Research Funding Scheme, Professional Services Advancement Support Scheme, and Monitoring and Evaluation Study of Kwai Tsing District Health Centre for the Government, Research Impact Fund.
Dr. Lui is committed to serve the community. For instance, she has been the IRB member of CUHK/NTEC (2011-2012).
She is a dedicated educator and has supervised 4 Ph.D. students, 2 M.Phil. students and 10 M.Sc. students. She has been the Deputy Co-Director of M.Sc. / Pg.D. in Sports Medicine and Health Science (2006-2013).

SPECIALISED RESEARCH AREAS Tendon Stem Cells and Their Niches
Tissue Engineering and Regenerative Medicine
Tendinopathy
Anterior Cruciate Ligament Reconstruction
Tendon and Ligament Healing


SELECTED PUBLICATION
1. Lui PPY*. Mesenchymal Stem Cell-derived Extracellular Vesicles for the Promotion of Tendon Repair - An Update of Literature. Stem Cell Rev Rep, 2020 Aug 12. doi: 10.1007/s12015-020-10023-8

2. Lui PPY*, Wong CM. Biology of tendon stem cells and tendon in aging. Front Genet, 2020; 10: 1338.

3. Lui PPY*, Wong OT, Lee WY. Transplantation of tendon-derived stem cells (TDSCs) pre-treated with connective tissue growth factor (CTGF) and ascorbic acid in vitro promoted better tendon repair in a patellar tendon window injury rat model. Cytotherapy, 2016; 18(1): 99-112.

4. Lui PPY*. Markers for the identification of tendon-derived stem cells (TDSCs) in vitro and tendon stem cells in situ – Update and future development. Stem Cell Res Ther 2015; 6: 106.

5. Lui PPY*, Kong SK, Lau PM, Wong YM, Lee WY, Tan C, Wong OT. Allogeneic tendon-derived stem cells (TDSCs) promote tendon healing and suppress immunoreactions in hosts – In vivo model. Tissue Eng Part A 2014; 20(21-22): 2998-3009.

6. Lui PPY*, Kong SK, Lau PM, Wong YM, Lee WY, Tan C, Wong OT. Immunogenicity and escape mechanisms of allogeneic tendon-derived stem cells (TDSCs). Tissue Eng Part A 2014; 20(21-22): 3010-3020.

7. Tan C, Lui PPY*, Lee YW, Wong YM. Scx-transduced tendon-derived stem cells (TDSCs) promoted better tendon repair compared to mock-transduced cells in a rat patellar tendon window injury model. PLoS One 2014; 9(5): e97453.

8. Lui PPY*, Wong OT, Lee YW. Application of the tendon-derived stem cell (TDSC) sheet for the promotion of graft healing in anterior cruciate ligament (ACL) reconstruction. Am J Sports Med 2014; 42(3): 681-689.

9. Tan Q, Lui PPY*, Lee YW. In vivo identity of tendon stem cells and the roles of stem cells in tendon healing. Stem Cells Dev 2013; 22(23): 3128-3140.

10. Lui PPY*, Lee YW, Mok TY, Cheuk YC, Chan KM. Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction. Eur Cell Mater 2013; 25: 78-96.

























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