Professor WANG Huating 王华婷
PhD(OSU), BS(NJU, China)
Professor of Orthopaedics and Traumatology
矫形外科及创伤学系教授

BIOGRAPHY
Dr. Wang is currently a Professor at Li Ka Shing Institute of Health Sciences, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong. She received her B.S degree in 1996 from Nanjing University, China and majored in Environmental Chemistry. In 1998 she moved to USA to pursue her PhD degree at the Ohio State University (OSU) with the award of a Research Assistantship. She studied Molecular Virology under the mentorship of Dr. Louis Mansky and obtained her PhD in 2004. She then remained at OSU since 2004 for her Postdoctoral training under the mentorship of Dr. Denis Guttridge with the support of a Postdoctoral Researcher Fellowship from The Comprehensive Cancer Center, OSU and later a F32 Postdoctoral Fellowship Award from National Institute of Health, USA. In 2009, after a successful Postdoctoral training, she moved to Hong Kong for an Assistant Professor position at Department of Obstetrics and Gynaecology, Faculty of Medicine, the Chinese University of Hong Kong. She then moved to Department of ORT and was soon promoted to Associate Professor in 2015 and Full Professor in 2020. Since 2004, she has developed life-long interest in studying gene regulatory mechanisms using skeletal muscle cells and cancer cells as model systems. Currently the main focus of her group is to study the functional roles of non-coding RNAs in regulating gene expression in skeletal muscle stem cells and muscle regeneration.

SPECIALISED RESEARCH AREAS Non-coding RNAs
Gene Regulation
Skeletal Muscle Stem Cell and Regeneration



SELECTED PUBLICATION
1. Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A. Esteban, Hao Sun, Wang H*. (2019) MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nat Commun 10, 5787 (2019).

2. Zhou J, So KK, Li Y, Li Y, Yuan J, Ding Y, Chen F, Huang Y, Liu J, Lee W, Li G, Ju Z, Sun H, Wang H*. (2019) Elevated H3K27ac in aged skeletal muscle leads to increase in extracellular matrix and fibrogenic conversion of muscle satellite cells. Aging Cell 2019 Jul 20:e12996.

3. Chen F, Zhou J, Li Y, Zhao Y, Yuan J, Cao Y, Wang L, Zhang Z, Zhang B, Wang CC, Cheung TH, Wu Z, Wong CC, Sun H, Wang H*. (2019) YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells. EMBO J. 2019 May 15;38(10).

4. Peng X, So KK, He L, Zhao Y, Zhou J, Li Y, Yao M, Xu B, Zhang S, Yao H, Hu P, Sun H, Wang H*. (2017) MyoD- and FoxO3-mediated hotspot interaction orchestrates super-enhancer activity during myogenic differentiation. Nucleic Acids Res. 2017 Sep 6;45(15):8785-8805.

5. Zhou J, Zhang S, Wang H*, Sun H. (2017) LncFunNet: an integrated computational framework for identification of functional long noncoding RNAs in mouse skeletal muscle cells. Nucleic Acid Res. 2017 Jul 7;45(12):e108

6. Chen X, He L, Zhao Y, Li Y, Zhang S, Sun K, So K, Chen F, Zhou L, Lu L, Wang L, Zhu X, Bao X, Esteban MA, Nakagawa S, Prasanth KV, Wu Z, Sun H, Wang H*. (2017) Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity. Cell Discov. 2017 Mar 14;3:17002.

7. Zhou, L., Sun, K., Zhao, Y., Zhang, S., Wang, X., Li, Y., Lu, L., Chen, X., Chen, F., Bao, X., Zhu, X., Wang, L., Tang, L. Y., Esteban, M. A., Wang, C. C., Jauch, R., Sun, H. & Wang, H.*. (2015) Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1. Nature Communications. 6:10026.

8. Wang, L., Zhao, Y., Bao, X., Zhu, X., Kwok, Y. K., Sun, K., Chen, X., Huang, Y., Jauch, R., Esteban, M. A., Sun, H., & Wang, H.*. (2015) LncRNA Dum Interacts with Dnmts to Regulate Dppa2 Expression during Myogenic Differentiation and Muscle Regeneration. Cell Research, 5(3):335–350.

9. Zhao, Y., Yang, Y., Trovik, J., Sun, K., Zhou, L., Jiang, P., Lau, T. S., Hoivik, E. A., Salvesen, H. B., Sun, H., & Wang, H.*. (2014) A Novel Wnt Regulatory Axis in Endometrioid Endometrial Cancer. Cancer Research, 74(18):5103-17.

10. Lu, L., Sun, K., Chen, X., Zhao, Y., Wang, L., Zhou, L., Sun, H., & Wang, H.*. (2013) Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis. EMBO Journal, 32(19), 2575-2588.

























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