Gao,Weiping

Me&Science:

Iamachemist,materialsscientistandbioengineerworkingattheinterfacesofchemistry,physics,biology,andmedicine,.Myresearchgoalistodevelopbiologicsandnanomedicinesforearlydiagnosisandtargetedtherapyofcancer,diabetes,cardiovascular,neurologicalandinfectiousdiseases.

ResearchInterests:

Nanobiomedicine,Biomaterials

ScientificFocus:

Nanobiomedicine:Developingprotein-polymerconjugates,geneticallyengineeredpolypeptide,geneticallyengineeredpolypeptide-drug/nucleicacid/nanomaterialconjugates,andtheirself-assemblednanomedicinesforearlydiagnosisandtargetedtherapyofmajordiseasessuchascancer,diabetes,cardiovascular,neurologicalandinfectiousdiseases.

Biomaterials:Developingbiomedicalpolymers,　functionalpolymers,biomacromolecules,surface-functionalized(stem)cellsandnanobiomaterialsfordrug/genedelivery,drugscreening,molecularimaginganddiagnosis,celltherapyandtissueengineering.

ResearchKeywords:

biomaterials,drugdeliverysystems,nanomedicine

ProfessionalOverview:

• 2011-PresentProfessorofNanobiomedicine&BiomaterialsDepartmentofBiomedicalEngineering,SchoolofMedicine,TsinghuaUniversity,Beijing,China
• 2007-2011PostdoctoralAssociateinsite-specificinsitugrowthofprotein-polymerconjugateswithimprovedpharmacologyDepartmentofBiomedicalEngineeringandCenterforBiologicallyInspiredMaterialsandMaterialSystem,DukeUniversity,NC,USAAdvisor:ProfessorAshutoshChilkoti
• 2005-2007Center-of-Excellence(COE)Researcherinstimulus-responsivewaterlubricationbyconcentratedpolymerbrushesInstituteforChemicalResearch,KyotoUniversity,Kyoto,JapanAdvisors:ProfessorTakeshiFukudaandProfessorYoshinobuTsujii
• 2004-2005ResearchAssociateinself-assemblyandnanomaterialsbasedonblockcopolymersDepartmentofPolymerScienceandEngineering,PekingUniversity,Beijing,ChinaAdvisor:ProfessorErqiangChen
• 2000-2004Ph.D.inPolymerChemistryandPhysicsDepartmentofPolymerScienceandEngineering,PekingUniversity,BeijingChinaThesis:Confinedphasetransitionandself-assemblyofblockcopolymersAdvisors:ProfessorQifengZhouandProfessorErqiangChen
• 1997-2000M.S.inChemicalEngineering,QingdaoInstituteofChemicalTechnology,Qingdao,China
• 1993-1997B.Sc.inChemicalEngineering,QingdaoInstituteofChemicalTechnology,Qingdao,China

SelectedPublications:

WeipingGao,DonghuaXu,DongWooLim,StephenL.Craig,AshutoshChilkoti.“Insitugrowthofathermoresponsivepolymerofageneticallyengineeredelastin-likepolypeptide”,Polym.Chem.,2011,2，1561-1566.

WeipingGao,WengeLiu,TrineChristensen,MichaelR.Zalutsky,AshutoshChilkoti.“InsitugrowthofaPEG-likepolymerfromtheC-terminusofaninteinfusionproteinimprovespharmacokineticsandtumoraccumulation”,Proc.Natl.Acad.Sci.USA2010,107,16432-16437.Note:ThispaperhasbeenhighlightedbyNatureandScience-BusinesseXchange(SciBX).

WeipingGao,WengeLiu,J.AndrewMackay,MichaelR.Zalutsky,EricJ.Toone,AshutoshChilkoti.“InsitugrowthofastoichiometricPEG-likeconjugateataprotein’sN-terminuswithsignificantlyimprovedpharmacokinetics”,Proc.Natl.Acad.Sci.USA2009,106,15231–15236.Note:ThispaperhasbeenhighlightedbymediaandjournalssuchasNature,ScienceDaily,andScience-BusinesseXchange(SciBX).

YuBai,WeipingGao,JingjingYan,YuguoMa,DehaiLiang,ZichenLi,BingyongHan,WantaiYang,ErqiangChen.“Co-aggregationprocessofpoly(ethyleneoxide)-b-polybutadiene/poly(acrylicacid)basedonevolutionofinterpolymerhydrogenbondinginsolutions”Polymer2008,49,2099-2106.

WeipingGao,YuBai,ErqiangChen,ZichenLi,BingyongHan,WantaiYang,QifengZhou.“Controllingvesicleformationviainterpolymerhydrogen-bondingcomplexationbetweenpoly(ethyleneoxide)-block-polybutadieneandpoly(acrylicacid)insolution”Macromolecules2006,39,4894-4898.