Zu,Liansuo

Me&Science:

Anaturalproductisachemicalcompoundorsubstanceproducedbyalivingorganism–foundinnaturethatusuallyhasapharmacologicalorbiologicalactivityforuseinpharmaceuticaldrugdiscoveryanddrugdesign.ThesesmallmoleculesprovidethesourceorinspirationforthemajorityofFDA-approvedagentsandcontinuetobeoneofthemajorsourcesofinspirationfordrugdiscovery.

ResearchInterests:

MedicinalChemistry,TotalSynthesisofNaturalProducts

ScientificFocus:

ResearchintheZulaboratoryisdirectedtowardthedevelopmentofhighlyefficientandpracticalsyntheticmethodologiesthatfacilitatethepreparationofprivilegedstructuresandbioactivenaturalproducts,andtheconstructionofsmallmoleculelibrariesthroughdiversityorientedsynthesis、divertedtotalsynthesisandfunctionorientedsynthesisinsearchingformedicinallyimportantleadcompounds.

ResearchKeywords:

drugdiscovery,naturalproducts

ProfessionalOverview:

ProfessorZureceivedaB.S.inPharmaceuticalSciencefromPekingUniversityin2001.Afterundergraduatestudy,heworkedasamedicinalchemistatChineseAcademyofMedicalSciences&PekingUnionMedicalCollegefor3years.ProfessorZuobtainedhisPh.D.in2008fromtheUniversityofNewMexicowhereheworkedonthedevelopmentoforganocatalyticasymmetrictransformationsunderthedirectionofProfessorWeiWang.HethenjoinedProfessorNeilGarg’slaboratoryin2009atUniversityofCalifornia,LosAngelesasapostdoctoralscholar,andhecompletedthetotalsynthesisofthecomplexindolealkaloidaspidophyllineA.AfteranothershortpostdoctoralexperiencewithProfessorDeanTantilloatUniversityofCalifornia,Davis,ProfessorZujoinedthefacultyatSchoolofMedicine,TsinghuaUniversityasanassociateProfessoronApril2012.

SelectedPublications:

1.TotalSynthesisoftheComplexFuroindolineAlkaloidAspidophyllineA.Zu,L.;Boal,B.W.;Garg,N.K.J.Am.Chem.Soc.2011,133,8877–8879.
2.CascadeMichael-AldolReactionsPromotedbyHydrogenBondingMediatedCatalysis.Zu,L.;Wang,J.;Li,H.;Xie,H.;Jiang,W.;Wang,W.J.Am.Chem.Soc.2007,129,1036–1037.
3.SynthesisofHighlyFunctionalizedChiralCyclopentanesbyCatalyticEnantio-andDiastereoselectiveDoubleMichaelAdditionReactions.Zu,L.;Li,H.;Xie,H.;Wang,J.;Jiang,W.;Tang,Y.;Wang,W.Angew.Chem.Int.Ed.2007,46,3732–3734.
4.EffectofIsotopicallySensitiveBranchingonProductDistributionforPentaleneneSynthase:SupportforaMechanismPredictedbyQuantumChemistry.Zu,L.;Xu,M.;Lodewyk,M.W.;Cane,D.E.;Peters,R.J.;andTantillo,D.J.J.Am.Chem.Soc.2012,134,11369–11371.
5.OrganocatalyticEnantioselectiveCascadeMichael-AlkylationReactions:SynthesisofChiralCyclopropanesandInvestigationofUnexpectedOrganocatalyzedStereoselectiveRingOpeningofCyclopropanes.Xie,H.;Zu,L.;Li,H.;Wang,J.;Wang,W.J.Am.Chem.Soc.2007,129,10886–10894.