Zhang,Xiaoning

Me&Science:

Themainresearchareaispharmaceutics,especiallynanobiotechnologyandnanomedicine.

ResearchInterests:

NanobiotechnologyandNanomedicine

ScientificFocus:

Designnovelactivetargetingnano-drugdeliverysystems(NDDS)fortumortargetingandgenetherapy.Inthisfield,wealsodesigntocombinegenetherapywithchemotherapybasedonnovelNDDStoreversetumormutidrugresistant（MDR）

DevelopnovelNDDSfororaladministrationandnoveltransdermaldrugdelivery.UtilizenewImagingmethodstostudyandevaluatebiologicaleffectsoftheseNDDSs.

StudythetransportmechanismofNDDStoprovidetheoreticalfoundationfornanomedicine.

ResearchKeywords:

genetherapy,nano-drugdeliverysystems(NDDS),tumortargeting

ProfessionalOverview:

• 2012-presentNationalDrugpriceassessmentexpertsofNDRC
• 2011-presentNationaldrugreviewexpertofSFDA
• 2004-presentAssociateProfessor,PrincipalInvestigatorofPharmaceuticsLab,SchoolofMedicine,TsinghuaUniversity
• 2002-2004Postdoct,DepartmentofBiosciencesandBiotechnology,TsinghuaUniversity
• 2000-2002Postdoct,AtomicandMolecularNanoSciencesLaboratory(MinistryofEducationofChina),DepartmentofPhysics,TsinghuaUniversity
• 1997-2000Ph.D.,BeijingInstituteofTechnology,MajorinMaterialScience.
• 1994-1997M.S.,BeijingInstituteofTechnology,MajorinPhysicalChemistry.
• 1989-1993B.S.,Xi'anJiaotongUniversity,MajorinPolymerScience.

SelectedPublications:

HuaDeng,XuZhang,AnilKumar,GuozangZou,XiaoningZhang*,Xing-JieLiang*.LonggenomicDNAampliconsadsorptionontounmodifiedgoldnanoparticlesforcolorimetricdetectionofBacillusanthracis.Chem.Commun.2013,49,51-53

KeyangHuang,HuiliMa,JuanLiu,ShuaidongHuo,AnilKumar,TuoWei,XuZhang,ShubinJin,YalingGan,PaulC.Wang,ShengtaiHe*,XiaoningZhang*,andXing-JieLiang*.Size-DependentLocalizationandPenetrationofUltrasmallGoldNanoparticlesinCancerCells,MulticellularSpheroids,andTumorsinVivo.ACSNANO,6(5),pp4483-4493,2012.

MingshuMa,YanliHao*,NanLiu,ZheYin,LanWang,Xing-JieLiang,XiaoningZhang*.Anovellipid-basednano-micelleofdocetaxel:evaluatedantitumorefficiencyandbiodistributionwithopticalimaginginvivo.InJNanomedicine,7,pp3389-3398,2012.

ZheYin,NanLiu,MingshuMa,LanWang,Xing-JieLiang,YanliHao*,XiaoningZhang*.AnovelEGFR-targetedgenedeliverysystembasedoncomplexesself-assembledbyEGF,DNAandactivatedPAMAMdendrimers,InJNanomedicine7,pp4625-4635,2012.

NanLiu,YanliHao*,ZheYin,MingshuMa,LanWang,XiaoningZhang*.Self-AssembledHumanSerumAlbumin-CoatedComplexesforGeneDeliverywithImprovedTransfection.DiePharmazie,67(2),pp174-181,2012/2.

LanWang,YanliHao*,NanLiu,ZheYin,MingshuMa,XiaoningZhang*.Enhancethedissolutionrateandoralbioavailabilityofpranlukastbypreparingnanosuspensionswithhigh-pressurehomogenizingmethod.DrugDevelopmentandIndustrialPharmacy,2012,38(11):1381-1389

XueXue,SongYou,QiangZhang,YanWu,Guo-zhangZou,PaulC.Wang,Yu-liangZhao,YanXu,LeeJia,XiaoningZhang,Xing-JieLiang*.MitaplatinIncreasesSensitivityofTumorCellstoCisplatinbyInducingMitochondrialDysfunction.MolecularPharmaceutics,2012,9(3),634?644

XiaoweiMa,YanyangWu,ShubinJin,YuanTian,XiaoningZhang,YuliangZhao,LiYu,XingjieLiang*.Goldnanoparticlesinduceautophagosomeaccumulationthroughsize-dependentnanoparticleuptakeandlysosomeimpairment.ACSNANO,2011,5(11):8629-8639

Feng-YunJ.Huang,Te-WeiLee,Chih-HaoK.Kao,Chih-HsienChang,XiaoningZhang,Wan-YuLee,Wan-JouChen,Shu-ChiWang,andJem-MauLo.Imaging,Autoradiography,andBiodistributionof188Re-LabeledPEGylatedNanoliposomeinOrthotopicGliomaBearingRatModel.CancerBiotherapy&Radiopharmaceuticals.2011,26(6):717-725.

MiWang,YueYuan,YangGao,HongmeiMa,HongtaoXu，XiaoningZhang,WeisanPan*.Preparationandcharacterizationof5-fluorouracilpHsensitiveniosomeanditstumortargetedevaluation:invitroandinvivo.DrugDevelopmentandIndustrialPharmacy,38(9),pp1134-1141,2012.

HongtaoXu,LingHe,ShufangNie,JinGuan,XiaoningZhang,XinggangYang,WeisanPan*.OptimizedpreparationofvinpocetineproliposomesbyanovelmethodandinvivoevaluationofitspharmacokineticsinNewZealandrabbits.J.ControlledRelease,2009,Nov16;140(1):61-8.

WeiWei,SanjunShi,JieLiu,XunSun,KeRen,DongZhao,XiaoningZhang,ZhirongZhang,TaoGong.Lipidnanoparticlesloadedwith10-hydroxycamptothecin-phospholipidcomplexdevelopedforclinicalapplication.J.DrugTargeting2010,18(7):557-566.

XiaoyuChen,XunSun,KeRen,XiaoningZhang*,ZhirongZhang,TaoGong*.Enhancedaqueoussolubilityandbioavailabilityofcapsaicinbythepreparationofinclusioncomplex.Arzneimittel-Forschung(DrugResearch)2010,60(9):571-574

XuanQin,YangYang,TingtingFan,TaoGong,XiaoningZhang,YuanHuang*.Preparation,characterizationandinvivoevaluationofbergeninphospholipidscomplex.ACTAPharmacol.Sin.2010,31(1):127-136.

Chun-YangZhuang;NingLi;MiWang;XiaoNingZhang;Wei-SanPan;Jun-JiePeng;Yu-ShengPan;XinTang.Preparationandcharacterizationofvinpocetineloadednanostructuredlipidcarriers(NLC)forimprovedoralbioavailability.InternationalJournalofPhamarceutics,2010,394(1-2):179-185.

FangFang,ChangyangGong,ZhiyongQian,XiaoningZhang,MalingGou,Chaoyou,LiangxueZhou,JiagangLiu,YuZhang,GangGuo,YingchunGu,FengLuo,LijuanChen,XiaZhao,YuquanWei*.HonokiolNanoparticlesinThermosensitiveHydrogel:TherapeuticEffectsonMalignantPleuralEffusion.ACS-NANO2009,3(12):4080-4088

ShaozhiFu,GangGuo,ChangyangGong,ShiZeng,HangLiang,FengLuo,XiaoningZhang,XiaZhao,YuquanWei,ZhiyongQian*.InjectableBiodegradableThermosensitiveHydrogelCompositeforOrthopedicTissueEngineering.1.PreparationandCharacterizationofNanohydroxyapatite/Poly(ethyleneglycol)-Poly(ε-caprolactone)-Poly(ethyleneglycol)HydrogelNanocomposites.J.Phys.Chem.B.2009,113(52):16518–16525

HuimingLai,FengZhu,WenminYuan,NaHe,ZhirongZhang,XiaoningZhang,QinHe.Developmentofmultiple-unitcolon-targeteddrugdeliverysystembyusingalginate:invitroandinvivoevaluation.DrugDevelopmentandIndustrialPharmacy,37(11),pp1347-1356,2011/11.

XuanmiaoZhang,XunSun,JilongLi,XiaoningZhang,TaoGong,ZhirongZhang.Lipidnanoemulsionsloadedwithdoxorubicin-oleicacidioniccomplex:characterization,invitroandinvivostudies.DiePharmazie,66(7),pp496-505,2011/7.

孙敏敏,郝艳丽,邰文,刘楠,马茗舒,殷哲,聂尚海,张小宁*.白蛋白紫杉醇聚合物胶束抑瘤效果研究.中国药学杂志,2011,46(3):55-59

郝艳丽,王兰,马茗舒,刘楠,殷哲,张小宁*.鸸鹋油纳米乳剂对急性高脂血症小鼠血脂的影响.中国农业科技导报，2011,13(1):94-97

王兰,郝艳丽,刘楠,马茗舒,张小宁.星点设计-效应面法优化普伦斯特磷脂复合物的制备.中国医药工业杂志,2011,42(11):815-818

邰文,孙敏敏,刘楠,黄志起,聂尚海,郝艳丽*,张小宁*.应用动物活体生物发光技术观察紫杉醇混合胶束的抑瘤效果.药学学报,2010,.45(4):530-534

殷哲，刘楠，马茗舒，王兰，郝艳丽*，张小宁*。自组装修饰在不同细胞系中对聚酰胺-胺介导的基因递送的影响。中国新药杂志2012，23（21）：pp2740-2743