Wang,Zhao

Me&Science:

Scienceistheknowledgeandtechnologywhatmakehumanmorehappyandmorehealthy.

ResearchInterests:

AgingPharmacology,PharmacologyandToxicologyofTCM

ScientificFocus:

Aging:Mechanismandintervention(viapharmacology)
-BrainAging:neurodegenerativediseasesincludingADanddrugdiscovery
-BoneAging:biomineralizationandosteoporosis
-BodyAging:mechanismsbynaturalsmall-molecularproducts
-Functionalresearchofthespermatogenesis-relatedgeneSPATA4onaging
-Molecular&CellularPharmacologyofNaturalProductsonagingandrelateddiseases
-R&DoftraditionalChineseherbalmedicineforclinicaldrugsandfunctionalfood

ResearchKeywords:

aging,chinesemedicine,pharmacology

ProfessionalOverview:

• 2003.12-PresentSchoolofMedicine,TsinghuaUniversity(Beijing,China)(Professor)
• 2006.09-2007.08MountSinaiSchoolofMedicine,NewYorkUniversity(NewYork,USA)(VisitingProfessor)
• 1998.04-2003.12DeptofBiologicalSciencesandBiotechnology,TsinghuaUniversity(Beijing,China)(AssociateProfessor,Professor)
• 1996.0401998.03DeptofPharmacology,NationalOkayamaUniversityMedicalSchool(Okayama,Japan)(AssistantProfessor)
• 1993.04-1996.03DoctorofPharmaceuticalScience(NationalOkayamaUniversity,Japan)
• 1990.06-1993.08MasterofPharmaceutics(NationalOkayamaUniversity,Japan)
• 1984.09-1987.07MasterofMedicine(BeijingUniversityofChineseMedicine)
• 1978.03-1982.12BachelorofMedicine(HenanCollegeofChineseMedicine)

SelectedPublications:

1.CongCheng,WeiguangLi,ZhengZhang,ShoheiYoshimura,QinyuHao,ChiZhangandZhaoWang*.MicroRNA-144IsRegulatedbyActivatorProtein-1(AP-1)andDecreasesExpressionofAlzheimer’sDisease-relatedADisintegrinAndMetalloprotease10(ADAM10).JBiolChem.Inpress
2.LangZhang,QingyangDing,PanWang,ZhaoWang*.Anupstreampromoterelementblocksthereversetranscriptionofthemouseinsulin-degradingenzymegene.BiochemBiophResCo.430(1):26-31(2013)
3.LangZhang,QingyangDing,ZhaoWang*.NuclearRespiratoryFactor1MediatestheTranscriptionInitiationofInsulin-DegradingEnzymeinaTATABox-BindingProtein-IndependentManner.PLoSONE.7(8):e42035(2012)
4.XuepingWu,YongshengCheng,TianLi,ZhaoWang,andJin-YuanLiu*.InvitroidentificationofDNA-bindingmotifforthenewzincfingerproteinAtYY1.ActaBiochimBiophysSin(Shanghai).44(6):483-9.(2012)
5.JunweiGuo,FangliRen,YinyinWang,ShanLi,ZhengrongGao,XiaoyanWang,HongxiuNing,JianguoWu,YiLi,ZhaoWang,ShekManChim,JiakeXu,ZhijieChang*.miR-764-5ppromotesosteoblastdifferentiationthroughinhibitionofCHIP/STUB1expression.JBoneMinerRes.27(7):1607-18(2012)
6.JiyongZhang,QiuyingLuan,YanzeLiu,DavidY-WLee,ZhaoWang*.AComparisonoftheDiastereoisomers,SilybinAandSilybinB,ontheInductionofApoptosisinK562cells.NaturalProductCommunications.6(11)1653-1656(2011)
7.HuiZhu,CongCheng,ChiZhang,ZhaoWang*.Echinacosidesuppressescellularsenescenceofhumanfibroblasticcellsbydown-regulationofp53.JournalofChinesePharmaceuticalSciences.20(5):523-528(2011)
8.XiaoyanWang,KenichiHarimoto,SijieXie,HaoCheng,JingLiu,StephenHinshaw,ZhijieChang,ZhaoWang*.Spata4promotesosteoblastdifferentiationthroughErk-activatedRunx2pathway.JBoneMinerRes.26(8):1964-73(2011)
9.XiaoyanWANG,ShangfengLIU,ZhaoWANG*.Pinctadafucatamantlegene5(PFMG5)frompearloystermantleinhibitsosteoblastdifferentiation.BiosciBiotechBioch.75(5):991-993(2011)
10.XiaoyanWang,ShangfengLiu,LipingXie,RongqingZhang,ZhaoWang*.Pinctadafucatamantlegene3(PFMG3)promotesdifferentiationinmouseosteoblasts(MC3T3-E1).CompBiochemPhysB.158(2):173-180(2011)
11.HuaqiangCao*,LuZhang,HeZheng,andZhaoWang*.HydroxyapatiteNanocrystalsforBiomedicalApplications.J.Phys.Chem.C.114:18352–18357(2010)
12.XiaoyanWANG,KenichiHARIMOTO,SijiaXIE,HaoCHENG,JingLIU,ZhaoWANG*.MatrixProteinBiglycanInducesOsteoblastDifferentiationthroughExtracellularSignal-RegulatedKinaseandSmadPathways.Biol.Pharm.Bull.,33(11):1891-1897(2010)
13.JingDu,LangZhang,ShuboLiu,ZhaoWang*.Palmiticacidanddocosahexaenoicacidopposinglyregulatetheexpressionofinsulin-degradingenzymeinneurons.DiePharmazie.65(3):231-232(2010)
14.HongXie,HuiZhu,CongCheng,YuLiang,ZhaoWang*.Echinacosideretardscellularsenescenceofhuman?broblasticcellsMRC-5.DiePharmazie.64(11):752-754(2009)
15.JingDu,LangZhang,ZhaoWang*.TestosteroneinhibitstheactivityofPPARginatranscriptionaltransactionassay.DiePharmazie.64(10):692-693(2009)
16.JianbinYan,ChiZhang,MinGu,ZhiyanBai,WeiguoZhang,TiancongQi,ZhiweiCheng,WenPeng,HaibinLuo,FajunNan*,ZhaoWang*,andDaoxinXie*.TheArabidopsisCoronatineInsensitive1ProteinisaJasmonateReceptor.PlantCell.21(8):2220-2236(2009)
17.JingDu,JunleiChang,SongxiGuo,QingZhang,ZhaoWang*.ApoE4ReducestheExpressionofAbdegradingenzymeIDEbyActivatingtheNMDAReceptorinHippocampalNeurons.NeuroscienceLetters.464(2):140-145(2009)
18.JingDu,ZhaoWang*.TherapeuticpotentialoflipaseinhibitororlistatinAlzheimer'sdisease.MedicalHypotheses.73(5):662-663(2009)
19.HaoGao,FengZhao,Guo-DongChen,Shao-DanChen,YangYu,Zhi-HongYao,BradW.C.Lau,ZhaoWang,JinLi,Xin-ShengYao*.BidesmosidetriterpenoidglycosidesfromStauntoniachinensisandrelationshiptoanti-inflammation.Phytochemistry.70:795-806(2009)
20.JingDu,BingSun,KuiChen,LiFan,ZhaoWang*.AntagonistofPeroxisomeProliferator-activatedReceptorInducesCerebellarAmyloid-LevelsandMotorDysfunctioninAPP/PS1TransgenicMice.BiochemBiophResCo.384(3):357-361(2009)
21.Zong-ChunYi*,Yan-ZeLiu,Hai-XiaLi,ZhaoWang*.ChebulinicacidandtellimagrandinIinhibitDNAstrandbreaksbyhydroquinone/Cu(II)andH2O2/Cu(II),butpotentiateDNAstrandbreaksbyH2O2/Fe(II).ToxicologyinVitro.23(4)667–673(2009)
22.JingDu,BingSun,KuiChen,LangZhang,ShuboLiu,QingquanGu,LiFan,NanmingZhao,ZhaoWang*.MetabolitesofNeuronsPlayEssentialRoleinPathogenesisofAlzheimer'sDisease.PLoSONE.4(5):e5530(2009)
23.JingDu,LangZhang,ShuboLiu,ChiZhang,XiuqingHuang,JianLi,NanmingZhao,ZhaoWang*.PPARgTranscriptionallyRegulatestheExpressionofInsulinDegradingEnzymeinPrimaryNeurons.BiochemBiophResCo.383(4):485-490(2009)
24.Zong-ChunYi*,Yan-ZeLiu,Hai-XiaLi,ZhaoWang*.ProoxidantactionofchebulinicacidandtellimagrandinI:Causingcopper-dependentDNAstrandbreaks.ToxicologyinVitro.23(3)425–431(2009)
25.QingzhiWu,HuaqiangCao*,QiuyingLuan,JiyongZhang,ZhaoWang*,JamieH.Warner,andAndrewA.R.Watt.Biomolecule-AssistedSynthesisofWater-SolubleSilverNanoparticlesandTheirBiomedicalApplications.InorganicChemistry.47(13)5882-5888(2008)
26.XueZHANG,Feng-JuanTU,Hai-YangYU,Nai-LiWANG,ZhaoWANG,andXin-ShengYAO.Copacamphane,PicrotoxaneandCyclocopacamphaneSesquiterpenesfromDendrobiumnobile.Chem.Pharm.Bull.56(6)854-857(2008)
27.HaoGao,ZhaoWang,LeiYang,YangYu,ZhihongYao,NailiWang,GuangxiongZhou,WencaiYe,XinshengYao.FivenewbidesmosidetriterpenoidsaponinsfromStauntoniachinensis.MagneticResonanceinChemistry.46(7)630-637(2008)
28.HaoGao,ZhaoWang,ZhihongYao,NingWu,HuajinDong,JinLi,NailiWang,WencaiYe,XinshengYao.UnusualnortriterpenoidglycosidesfromStauntoniachinensis.Helveticachimacaacta.91(3)451-459(2008)
29.MinFu,RuxinLi,LiFan,GuoweiHe,KentLThornburg,ZhaoWang*:SarcoplasmicReticulumCa2+ReleaseChannelRyanodineReceptor(RyR2)PlaysaCrucialRoleinAconitine-inducedArrhythmias.BiochemicalPharmacology.75(11)2147-2156(2008)
30.JinghuaJin,YuLiang,HongXie,XueZhang,XinshengYao,ZhaoWang*:DendroflorinRetardstheSenescenceofMRC-5Cells.DiePharmazie.63(4)321-323(2008)
31.XueZhang,Hong-WeiLiu,HaoGao,Hui-YingHan,Nai-LiWang,Hou-MingWu,Xin-ShengYao,ZhaoWang:NineNewSesquiterpenesfromDendrobiumnobile.HelveticaChimicaActa.90(12):2386-2394(2007)
32.MingchaoXie,ChaoAi,ShangfengLiu,ShixinTao,ZhaoWang*：CloningandcharacterizationofchickenSPATA4geneandanalysisofitsspecificexpression.MolecularandCellularBiochemistry.306(1-2):79-85(2007)
33.HaifengChen,GuanghuiWang,NailiWang,MengsuYang,ZhaoWang,XiaoweiWang,XinshengYao:NewfurostanolsaponinsfromthebulbsofAlliumMacrostemonBungeandtheirCytotoxicactivity.Pharmazie.62(7):544-548(2007)
34.MinFu,MengWu,JifengWang,YanjiangQiao,ZhaoWang*:DisruptionoftheIntracellularCa2+HomeostasisintheCardiacExcitation-ContractionCouplingisaCrucialMechanismofArrhythmicToxicityinAconitine-inducedCardiomyocytes.BiochemBiophResCo.354(4):929-936(2007)
35.LiuHai-Luo,LiuShang-Feng,GeYe-Jing,LiuJing,WangXiao-Yan,XieLi-Ping,ZhangRong-Qing,WangZhao*:IdentificationandcharacterizationofabiomineralizationrelatedgenePFMG1highlyexpressedinthemantleofpinctadafucata.Biochemistry.46(3):844-851(2007)
36.MinFu,MengWu,Ji-fengWan,Yan-jiangQiao,ZhaoWang:ToxicologicalMechanismsofAconitumAlkaloids.Pharmazie.61(9)735-741(2006)
37.Zong-ChunYi,ZhaoWang*,Hai-XiaLi,YanYin,Feng-YuanZhuang,andYu-BoFan:TellimagrandinIenhancesgapjunctionalcommunicationandattenuatesthetumorphenotypeofhumancervicalcarcinomaHeLacellsinvitro.CancerLetters.242(1)77-87(2006)
38.Shang-fengLiu,ChaoAi,Zhong-qiGe,Hai-luoLiu,Bo-wenLiu,ShanHe,ZhaoWang*:MolecularcloningandbioinformaticanalysisofSPATA4gene.JBiochemMolBiol.38(6)739-747(2005)
39.QingliuHU,JunleiCHANG,LitaoTAO,GuoliangYAN,MingchaoXIE,ZhaoWANG*:Endoplasmicreticulummediatednecrosis-likeapoptosisofHelacellsinducedbyCa2+oscillation.JBiochemMolBiol.38(6)709-716(2005)
40.YingZhao,HongGuan,Shang-FengLiu,Rong-CongWu,ZhaoWang*:OverexpressionofQMInducesCellDifferentiationandMineralizationinMC3T3-E1.Biological&PharmaceuticalBulletin.28(8)1371-1376(2005)
41.Shang-FengLiu,Bo-WenLiu,ShanHe,YingZhao,ZhaoWang*:CloningandcharacterizationofzebrafishSPATA4geneandanalysisofitsgonadspecificexpression.Biochemistry(Moscow).70(6)79-90(2005)
42.MingjieLiu,ZhaoWang*,SuqinSun,QingyuWu:Monitoringall-trans-retinoicacid-induceddifferentiationofHL-60cellsbyFourier-transforminfraredspectroscopy.SpectroscopyandSpectralAnalysis.25(5)688-692(2005)
43.Ming-JieLiu,PatrickYing-KitYue,ZhaoWangandRickyNgok-ShunWong:MethylprotodioscininducesG2/MarrestandapoptosisinK562cellswiththehyperpolarizationofmitochondria.CancerLetters.224(2)229-241(2005)
44.BowenLiu,ShangfengLiu,ShanHe,YingZhao,HongxiaHu,ZhaoWang*:CloningandexpressionanalysisofgonadogenesisassociatedSPATA4genefromrainbowtrout(Oncorhynchusmykiss).JBiochemMolBiol.38(2)206-210(2005)
45.Ming-JieLiu,ZhaoWang*,YongJu,RickyNgok-ShunWong,Qing-YuWu:DiosgenininducescellcyclearrestandapoptosisinhumanleukemiaK562cellswiththedisruptionofCa2+homeostasis.CancerChemotherapyandPharmacology.55(1)79-90(2005)
46.ZhaoWang*,PeilinZHANG,YongJU:EffectofLeonurineontheActivityofCreatineKinase.JournalofAsianNaturalProductsResearch.6(4)281-287(2004)
47.Shang-FengLiu,ShanHe,Bo-WenLiu,ZhaoWang*:Cloningandcharacterizationoftestis-specificspermatogenesisassociatedgenehomologoustohumanSPATA4inrat.Biological&PharmaceuticalBulletin.27(11)1867-1870(2004)
48.Wu,ZhaoWang*,Ming-JieLiu,Di-FeiChen,Xiao-ShanYue:b2-integrinsmediateanovelformofchemoresistanceincycloheximide-inducedU937apoptosis.CellularandMolecularLifeSciences.61(16)2071-2082(2004)
49.YiZongchun,ZhangMin,FuJuanlin,WangZhao，ZhouZongcan:Down-RegulationofMitoticCheckpointFunctioninTransformedHumanEmbryoLungFibroblastsInducedbyN-Methyl-N’-nitro-N-nitrosoguaridine.ChineseMedicalJournal.117(7)1079-1083(2004)
50.RongcongWu,DifeiChen,Ming-JieLiu,ZhaoWang*:DualEffectsofCycloheximideonU937ApoptosisInducedbyItsCombinationwithVP-16.Biological&PharmaceuticalBulletin.27(7)1075-1080(2004)
51.Ming-JieLiu,ZhaoWang*,YongJu,JiangbingZhou,YuWang,RickyNgok-ShunWong:TheMitotic-ArrestingandApoptosis-InducingEffectsofDiosgenylSaponinsonHumanLeukemiaCellLines.Biological&PharmaceuticalBulletin.27(7)1059-1064(2004)
52.ShangfengLiu,LuyunLi,LiuGang,XiaoweiXing,GuangxiuLu,ZhaoWang*:CloningofafulllengthcDNAofhumantestis-specificspermatogeniccellapoptosisinhibitorTSARG2ascandidateoncogene.BiochemicalandBiophysicalResearchCommunications(BBRC).319,32-40(2004)
53.HongjunZhang,ZhaoWang*,JiangbingZhou:CytoplasmPreparedfromAll-transRetinoicAcid(ATRA)-TreatedHumanHematopoieticProgenitorCellsInducesDifferentiationofBothATRASensitiveandATRAResistantLeukemiaCells.Biological&PharmaceuticalBulletin.27(4)570-573(2004)
54.ZongchunYi,ZhaoWang*,HaixiaLi,MingjieLiu:InhibitoryEffectofTellimagrandinIonChemicallyInducedDifferentiationofHumanLeukemiaK562Cells.ToxicologyLetters.147(2)109-119(2004)
55.ZongchunYi,ZhaoWang*,HaixiaLi,MingjieLiu,RongcongWu,XiaohuiWang:EffectsofChebulinicAcidonDifferentiationofHumanLeukemiaK562Cells.ActaPharmacologicaSinica.25(2)231-238(2004)
56.Ming-JieLiu,ZhaoWang*,Hai-XiaLi,Rong-CongWu,Yan-ZeLiu,Qing-YuWu:MitochondrialdysfunctionasanearlyeventintheprocessofapoptosisinducedbyWoodfordinIinhumanleukemiaK562cells.ToxicologyandAppliedPharmacology.194(2)141-155(2004)(cover)
57.YongZhang,JieHuang,QingxiongMeng,Tiemin,Jiang,LipingXie,ZhaoWang,RongqingZhang:MolecularCloningandExpressionofaPearlOyster(Pinctadafucata)HomologueofaMammalianPutativeTumorSuppressorQM.MarineBiotechnology.6(1)8-16(2004)
58.MingjieLiu,ZhaoWang*,RongcongWu,SuqinSun,QingyuWu:Monitoringall-trans-retinoicacid-induceddifferentiationofhumanacutepromyelocyticleukemiaNB4cellsbyFourier-transforminfraredspectroscopy.Leukemia.171670-1674(2003)