Xiao,Bailong

Me&Science:

NoPainNoGain!Enjoythefunofdiscovery!

ResearchInterests:

MolecularPharmacology/Neurobiology

ScientificFocus:

Ionchannelsarefundamentalmembraneproteinsthatregulatetheflowofionsacrosscellmembranesandcontrolcellexcitabilityandfunction.Inappropriatechannelactivitiescausedbyeithermutationsorabnormalphysiologicalregulationsunderlietheetiologyofnumerouspathologies(collectivelyknownaschannelopathies).Thus,anunderstandingoftheirstructureandfunctionislikelytoleadtothedevelopmentofnewtherapeutics.Ourlaboratoryisinterestedininvestigatingthestructure-functionrelationship,physiologicalandpathophysiologicalrolesoftheso-calledsensoryionchannelssuchastemperature-activatedTransientReceptorPotential(TRP)channels(thermoTRPs),CalciumReleaseActivatedCalcium(CRAC)channels,andthenewlyidentifiedmechanicallyactivatedPiezochannels.Thesechannelscanfunctionasreceptorsfortouchstimuliincludingtemperature,chemicals,andmechanicalforce,andconsequentlygovernthesenseoftouch.Byfocusingoncharacterizingknownsensorychannelsandidentifyingnovelones,weaimtobetterunderstandthemolecularandcellularmechanismsofthesenseoftouchandpainandotherrelatedphysiologicalprocessessuchasinflammatoryresponseswithanultimategoalofidentifyingnoveltherapeutics.Techniquesemployedinourresearchincludemolecularbiology,biochemistry,singlecellorhigh-throughputcalciumimaging,electrophysiology,siRNAorcompoundlibraryscreening,generationandbehavioralanalysisoftransgenicmice,etc.Positionsforpostdoctoralfellow,graduatestudentandtechnicianareavailableinourlaboratory.

ResearchKeywords:

drugdiscovery,ionchannel,touchandpain

ProfessionalOverview:

• 2013-PresentPrincipleInvestigator,Dept.ofPharmacologyandPharmaceuticalSciences,TsinghuaUniversity,Beijing,China
• 2013-PresentPrincipleInvestigator,Tsinghua-BeijingUniversitiesCenterforLifeSciences,Beijing,China
• 2007-2012PostdoctoralResearchAssociate,TheScrippsResearchInstitute,USA
• 2007-2012VisitingScientist，GenomicsInstituteoftheNovartisResearchFoundation,USA
• 2001-2006Ph.D.,CardiovascularandRespiratorySciences,UniversityofCalgary,Canada
• 1997-2001B.S.,Dept.ofBiochemistry,SunYat-Sen(zhongshan)University,China

HonorsandAwards:
2012SelectedasaYoung1000Planscholar2012Conference/TravelAwardoftheIonChannelGordonResearchConference
2010-2012AmericanHeartAssociationPostdoctoralFellowship,
2007-2010TheCanadianInstitutesofHealthResearchPostdoctoralFellowship,
2007-2010AlbertaHeritageFoundationforMedicalResearchPostdoctoralFellowship
2001-2006Ph.D.,CardiovascularandRespiratorySciences,UniversityofCalgary,Canada
2004,2005HonoraryUniversityofCalgarySilverAnniversaryGraduateFellowship
2004TheDr.MonicaScarabelloMemorialScholarship,UniversityofCalgary
2001DifferentialFeeScholarship,UniversityofCalgary

SelectedPublications:

BertrandCoste(co-first),BailongXiao(co-first),JoseS.Santos,RuhmaSyeda,JorgGrandl,KathrynS.Spencer,SungEunKim,ManuelaSchmidt,JayantiMathur,AdrienneE.Dubin,MauricioMontal,ArdemPatapoutian(2012).PiezoProteinsArePore-formingSubunitsofMechanicallyActivatedChannels.Nature.2012Feb19;483(7388):176-81PMID:22343900(SelectedbyFacultyof1000;FeaturedbyNatureNews&Views;TSRINews&Views;ReportedbyScienceDaily)

BailongXiao,BertrandCoste,JayantiMathur,ArdemPatapoutian(2011).Temperature-dependentSTIM1activationinducesCa2+influxandmodulatesgeneexpression.NatChemBiol.2011Jun;7(6):351-8.PMID:21499266(Nominatedfor2011signalingbreakthroughsoftheyearbyScienceSignaling;FeaturedbyNatChemBiol.News&Views;FeaturedbyTSRINews&Views;ReportedbyScienceDaily)

BailongXiao,ArdemPatapoutian(2011).Scratchingthesurface:aroleofpain-sensingTRPA1initch.NatNeurosci.2011May;14(5):540-2.PMID:21522144News&Views

BailongXiao,AdrienneE.Dubin,BadryBursulaya,VeenaViswanath,TimothyJ.Jegla,ArdemPatapoutian(2008).IdentificationofTransmembraneDomainFiveasaCriticalMolecularDeterminantofMentholSensitivityinMammalianTRPA1Channels.JNeurosci.2008Sep24;28(39):9640-51.

LindseyJ.Macpherson(co-first),BailongXiao(co-first),KelvinY.Kwan(co-first),MattJ.Petrus,AdrienneE.Dubin,SunWookHwang,BenjaminCravatt,DavidP.Corey,ArdemPatapoutian(2007).AnIonChannelEssentialforSensingChemicalDamage.JNeurosci.2007Oct17;27(42):11412-5.

BailongXiao,XixiTian,WenjunXie,PeterP.Jones,ShitianCai,XianhuaWang,DaweiJiang,LinZhang,KeyunChen,MichaelP.Walsh,HepingCheng,andS.R.WayneChen(2007).FunctionalConsequenceofPKA-dependentPhosphorylationoftheCardiacRyanodineReceptor:SensitizationofStore-overload-inducedCa2+release(SOICR).JBiolChem.2007Aug10.

BailongXiao,GuofengZhong,MasakazuObayashi,DongmeiYang,MichaelP.Walsh,YakhinShimoni,HepingCheng,HenkterKeurs,andS.R.WayneChen(2006).Serine-2030,butnotSerine-2808,istheMajorRyR2PhosphorylationSiteRespondingtoPKAActivationuponbeta-adrenergicStimulationinNormalandFailingHearts.BiochemJ.2006Feb17.(Commentedbyeditorial)

BailongXiao,MingTaoJiang,MingcaiZhao,DongmeiYang,CindySutherland,F.AnthonyLai,MichaelP.Walsh,HepingCheng,DavidC.Warltier,andS.R.WayneChen(2005).CharacterizationofaNovelProteinKinaseAPhosphorylationSite,Serine-2030,RevealsNoPKAHyperphosphorylationoftheCardiacRyanodineReceptorinCanineHeartFailure.CircRes.2005Apr29;96(8):847-55.

BailongXiao,CindySutherland,MichaelP.Walsh,S.R.WayneChen(2004).ProteinKinaseAPhosphorylationatSerine-2808oftheCardiacCa2+-ReleaseChannel(RyanodineReceptor)DoesNotDissociate12.6-kDaFK506-BindingProtein(FKBP12.6).CircRes.2004Mar5;94(4):487-95.

BailongXiao,HarukoMasumiya,DaweiJiang,RuiwuWang,YoshitatsuSei,LinZhang,TakashiMurayama,YasuoOgawa,F.AnthonyLai,TerenceWagenknecht,andS.R.WayneChen(2002).IsoformDependentFormationofHeteromericCa2+ReleaseChannels(RyanodineReceptors).JBiolChem.2002Nov1;277(44):41778-85.(SelectedbyFacultyof1000)

AdrienneE.Dubin,ManuelaSchmidt,JayantiMathur,MattJ.Petrus,BailongXiao,BertrandCoste,ArdemPatapoutian.Inflammatorysignalsenhancepiezo2-mediatedmechanosensitivecurrents.CellRep.2012Sep27;2(3):511-7.Epub2012Aug23.PMID:22921401

PeterP.Jones,XingMeng,BailongXiao,ShitianCai,JeffBolstad,TerenceWagenknecht,ZhengLiuandS.R.WayneChen(2008).LocalizationofPKAphosphorylationsite,Ser2030,inthethree-dimensionalstructureofcardiacryanodinereceptor.BiochemJ.2008Mar1;410(2):261-70.

XingMeng,BailongXiao,ShitianCai,XiaojunHuang,FeiLi,JeffBolstad,RamonTrujillo,JudithAirey,S.R.WayneChen,TerenceWagenknecht,andZhengLiu(2007).Three-DimensionalLocalizationofSerine2808,aPhosphorylationSiteinCardiacRyanodineReceptor.JBiolChem.2007Aug31;282(35):25929-39.

DongmeiYang,Wei-ZhongZhu,BailongXiao,DidierX.P.Brochet,S.R.WayneChen,EdwardG.Lakatta,Rui-PingXiaoandHepingCheng(2007).Ca2+/calmodulinkinaseII-dependentPhosphorylationofRyanodineReceptorsSuppressesCa2+SparksandCa2+WavesinCardiacMyocytes.CircRes.2007Feb16;100(3):399-407.

MasakazuObayashi,BailongXiao,BrunoD.Stuyvers,AllenW.Davidoff,JieMei,S.R.WayneChen,HenkE.D.J.terKeurs(2006).Spontaneousdiastoliccontractionsandphosphorylationofthecardiacryanodinereceptoratserine-2808incongestiveheartfailureinrat.CardiovascRes.2006Jan;69(1):140-51.

DaweiJiang,RuiwuWang,BailongXiao,HuihuiKong,PhilipChoi,LinZhang,andS.R.WayneChen(2005).EnhancedStoreOverloadInducedCa2+Release(SOICR)andChannelSensitivitytoLuminalCa2+ActivationisaCommonDefectofRyR2MutationsLinkedtoVentricularTachycardiaandSuddenDeath.CircRes.2005Nov25;97(11):1173-81.(Commentedbyeditorial)

DaweiJiang,BailongXiao,DongmeiYang,RuiwuWang,PhilipChoi,LinZhang,HepingCheng,andS.R.WayneChen(2004).RyanodineReceptorMutationsAssociatedwithVentricularTachycardiaandSuddenCardiacDeathReducetheThresholdforStoreOverloadInducedCa2+Release(SOICR).ProcNatlAcadSciUSA.2004Aug31;101(35):13062-7.

DaweiJiang,BailongXiao,XiaoliLi,andS.R.WayneChen(2003).SmoothMuscleTissuesExpressaMajorDominant-NegativeSpliceVariantoftheType3Ca2+ReleaseChannel(RyanodineReceptor)JBiolChem.2003Feb14;278(7):4763-9.(SelectedbyFacultyof1000)

HarukoMasumiya,RuiwuWang,JingZhang,BailongXiao,S.R.WayneChen(2003)Localizationofthe12.6-kDaFK506-bindingprotein(FKBP12.6)bindingsitetotheNH2-terminaldomainofthecardiacCa2+releasechannel(ryanodinereceptor).JBiolChem.2003Feb7;278(6):3786-92.

DaweiJiang,BailongXiao,LinZhang,S.R.WayneChen(2002).EnhancedBasalActivityofaCardiacCa2+ReleaseChannel(RyanodineReceptor)MutantAssociatedWithVentricularTachycardiaandSuddenDeath.Circ.Res.9;91(3):218-25.(Commentedbyeditorial)

FullPublications:

http://www.ncbi.nlm.nih.gov/pubmed/?term=Bailong+Xiao