Tang,Yefeng

Me&Science:

Chemistryisadisciplinetostudythestructureofmolecules,whilebiologyfocusesoninvestigationoftheirfunctionsandmechanismofaction.Bioactivemolecules,eitherderivedfromnaturalresourceorsyntheticorigin,couldseverasthebridgetoconnectchemistry,biologyandmedicinetogether.Therefore,design,synthesisandapplicationofbioactivemoleculeshavebeenstandinginthecentralstageofourresearches.Principally,weprefertodefineourresearchasbiologicalfunction-orientedchemicalsynthesis,whereintheinventionanddevelopmentofnewchemistries(e.g.novelreactionandstrategy)andapplicationoftheminbioactivemoleculesynthesisrankthetoppriorityofourfocuses,whiletheinvestigationofthebiologicalfunctionsandmechanismofactionofthosesynthesizedbiologicalmoleculesserveasthemajordrivingforce.

ResearchInterests:

SyntheticOrganicChemistry,MedicinalChemistry

ScientificFocus:

• SyntheticOrganicChemistry:including1)thetotalsynthesisofnaturalproductswithimportantbiologicalprofile,uniquemoleculararchitectureandnovelbiosyntheticpathway,and2)thedevelopmentofnewsyntheticmethodologiesthatcanbeappliedtorapidaccessofnaturalproductsandsmallmoleculelibraries.
• MedicinalChemistry:rationaldesign,synthesisandbiologicalevaluationofmoleculeswithanti-viralactivities(e.g.anti-HIV,anti-HCVandanti-Flu)andidentificationofnewdrugleadcompoundswithpotentialmedicaluse.
• ChemicalBiology:rapidconstructionofsmallmoleculelibrarieswithstructurediversityandnovelty,andtheirapplicationsinthechemicalbiologystudyanddrugresearch.

ResearchKeywords:

chemicalsynthesis,medcinalchemistry,naturalproducts

ProfessionalOverview:

• 2010-Present:Principleinvestigator,DepartmentofPharmacology&PharmaceuticalSciences,andTheComprehensiveAidsResearchCenter,MedicalSchool,TsinghuaUniversity.
• 2006-2009:ResearchAssociate,DepartmentofChemistry,TheScrippsResearchInstitute(withProf.K.C.Nicolaou).
• 2003-2006:Ph.D.,OrganicChemistry,CollegeofChemistryandMolecularEngineering,PekingUniversity(withProf.ZhenYangandJiahuaChen).
• 1999-2002:M.S.,MedicinalChemistry,InstituteofMateriaMedica,PekingUnionMedicalCollegeandChineseAcademicofMedicalSciences(withProf.ShizhiChen).
• 1995-1999:B.S.,OrganicChemistry,InstituteofChemistryandChemicalEngineering,LanzhouUniversity.

SelectedPublications:

Gold-CatalyzedRearrangementofAllylicOxoniumYlides:EfficientSynthesisofHighlyFunctionalizedDihydrofuran-3-ones.Fu,J.K.;Shang,H.;Wang,Z.F.;Chang,L.;Shao,W.B.;Yang,Z.*;TangY.F.*Angew.Chem.Int.Ed.2013,52,4198-4202.

Organocatalytic1,4-ConjugateAdditionofAscorbicAcidtoa,b-UnsaturatedAldehydes:Bio-inspiredTotalSynthesesofLeucodrin,LeudrinandProposedStructureofDilaspirolactone.WangZ.F.;Zhao,K.;Fu,J.K.;Zhang,J.L.;YinW.Y.;Tang,Y.F.*Org.Biomol.Chem.,2013,11,2093-2097.

TotalSynthesisofIncarvilleatoneandIncarviditone:InsightintoTheirBiosyntheticPathwaysandStructureDetermination.Zhao,K.;Cheng,G.J;Yang,H.Z;Shang,H.;Zhang,X.H.;Wu,Y.D.*;Tang,Y.F.*Org.Lett.,2012,14,4878-4881.

EnantioselectiveandCollectiveSynthesesofXanthanolidesbyControllableDyotropicRearrangementofcis-b-Lactones.Ren,W.W.;Bian,Y.C.;Zhang,Z.Y.;Shang,H.;Zhang,P.T.;Chen,Y.J.;Yang,Z.*;LuoT.P.*;TangY.F.*Angew.Chem.Int.Ed.2012,51,6984-6988.

EnantioselectiveBiomimeticTotalSynthesesofKatsumadainandKatsumadainC.Zhang,P.T.;Wang,Y.G.;Bao,R.Y.;Luo,T.P.;Yang,Z.*;TangY.F.*Org.Lett.,2012,14,162-165.

DiastereoselectiveTotalSynthesisof(+)-SchindilactoneA.X.Qing,RenW.W;Chen,Z.X.;Sun,T.W.;Li,Y.;Ye,Q.D.;Gong,J.X.;Meng,F.K.;You,L.;Liu,Y.F.;Zhao,M.Z.;Xu,L.M.;Shan,Z.H.;Shi,Y.;Tang,Y.F.*;Chen,J.H.*;YangZ.*.Angew.Chem.Int.Ed.2011,50,7373–7377.

RapidBiomimeticTotalSynthesisof(±)-RossinoneB,ZhangZiyang;ChenJiahua;YangZhen*;TangYefeng*.Org.Lett.2010,12,5554-5557.

TotalSynthesisofSporolideB.Nicolaou,K.C*.;Tang,Y.F.;Wang,J.H..Angew.Chem.Int.Ed.2009,121,3501-3505.

TotalSynthesisandAntibacterialPropertiesofCarbaplatensimycin.Nicolaou,K.C*.;Tang,Y.F.;Wang,J.H.J.Am.Chem.Soc.2007,129,14850-14851.

FormalSynthesisof(+)-Platensimycin.Nicolaou,K.C*.;Tang,Y.F.;Wang,J.H.Chem.Comm.2007,1922-1923.