Wang,Jian

Me&Science:

Thesecretofbeingasuccessfulscientistis...workinghardandlookingahead.
Guaranteedtomakemesmileis...whenmyresearchpredictionscometrue.

ResearchInterests:

SyntheticOrganicChemistry,PharmaceuticalScience

ScientificFocus:

• SyntheticOrganicChemistry:

1.Developmentofnewsyntheticmethodologiesthatcanbeappliedtorapidaccessofpharmaceuticals,naturalproducts,andpotentialbioactivemolecules;
2.Totalsynthesisofnaturalproductswithnovelbiosyntheticstrategy.
3.Developmentofnewtechnologyinthesynthesisofpharmaceuticals.

• MedicinalChemistry:

1.Rationaldesign,synthesisandbiologicalevaluationofsmallmoleculeswithbioactivitiesunderthecontextofanti-cancer,anti-virus,anti-infectious,anti-HIV,etc.
2.Identificationofleadcompoundsformedicaluse.

• ChemicalBiology:

Fluorescentdyeshavebeenwidelyusedassensorsandprobesduetotheirhighsensitivityandexceptionaleaseofhandling.Ourmainfocusinthisdirectionistodiscovernewhighlyimprovedsensors.

ResearchKeywords:

chemicalbiology,drugdiscovery,organicsynthesis

ProfessionalOverview:

• 2012:Chief-in-editorofEuropeanJournal“NaturalProductsAgainstCancer”(Versita)
• 2012:“1000TalentProgram”(CategoryC:YouthGroup),Chinesegovernment
• 2013-present:PrincipalInvestigator,TsinghuaUniversity
• 2009-2013:AssistantProfessor(TenureTrack),DepartmentofChemistry,NationalUniversityofSingapore
• 2011-2013:jointappointmentinNUSGraduateSchoolforIntegrativeSciencesandEngineering,NationalUniversityofSingapore
• 2009-2013:jointappointmentinMedicinalChemistryProgramme,NationalUniversityofSingapore
• 2007-2009:Postdoc,TheScrippsResearchInstitute,California,USA,(Advisor:Prof.PeterG.Schultz)
• 2003-2007:Ph.D.inChemistry,UniversityofNewMexico,USA(Advisor:Prof.WeiWang)
• 1997-2001:InstituteofPhotographicChemistry,CAS(Advisor:Prof.HuijunXuandProf.Chen-hoTung)
• 1993-1997:B.S.,AnhuiNormalUniversity,Anhui,China

SelectedPublications:

1.Boitano,A.E.;Wang,J.;Romeo,R.;Bouchez,L.G.;Parker,A.E;Sutton,S.U.;Walker,J.R.;Flaveny,C.A.;Perdew,G.H;Denison,M.S.;Schultz,P.G.,Cooke,M.P.“ArylHydrocarbonReceptorAntagonistsPromotetheExpansionofHumanHematopoieticStemCells”,Science,2010,329,1345-1348.(ThisarticlehasbeenhighlightedinmanyMagazinessuchasC&ENews,Nature,etc.)
2.Zhu,S.T.;Wurdak,H.;Wang,J.;Lyssiotis,C.A.;Peters,E.C.;Cho,C.Y.;Wu,X.;Schultz,P.G."ASmallMoleculePrimesEmbryonicStemCellsforDifferentiation",CellStemCell,2009,4(5),416-426.(ThisarticlehasbeenhighlightedinCell,Nature,andScience)
3.Wang,L.;Huang,J.Y.;Liu,H.;Peng,S.Y.;Jiang,X.-F.;Wang,J.*“Palladium-catalyzedOxidativeCycloadditionviaC–H/N–HActivation:AccesstoBenzazepines”,Angew.Chem.Int.Ed.,2013,52,1768.
4.Wang,J.;Xie,H.-X.;Li,H.;Zu,L.-S.;Wang,W.“AHighlyStereoselectiveHydrogen-Bond-MediatedMichael-MichaelCascadeProcessthroughDynamicKineticResolution”,Angew.Chem.Int.Ed.,2008,47,4177.(Thisarticlehasbeenselectedas“HotPapers”ofAngew.Chem.Int.Ed.)
5.Wang,J.;Li,H.;Zu,L.-S.;Wang,W.“OrgancatalyticEnantioselectiveConjugateAdditionstoEnones”,J.Am.Chem.Soc.,2006,128,12652.(Thisworkhasbeenrecognizedas“HotPapers”ofJ.Am.Chem.Soc.)
6.Wang,J.;Li,H.;Xie,H.-X.;Zu,L.-S.;Shen,X.;Wang,W.“OrganocatalyticEnantioselectiveCascadeMichael-AldolCondensationReactions:EfficientAssemblyofDenselyFunctionalizedChiralCyclopentenes”,Angew.Chem.Int.Ed.,2007,46,9050.(Thisarticlehasbeenselectedas“HotPapers”ofAngew.Chem.Int.Ed.)
7.Wang,J.;Li,H.;Wang,W.;“Direct,HighlyEnantioselectivePyrrolidineSulfonamideCatalyzedMichaelAdditionReactionsofAldehydestoNitrostyrenes”,Angew.Chem.Int.Ed.,2005,44,1369.(ThisworkhasbeenhighlightedinOrg.Chem.Highlights2006,January30.URL:http://www.organic-chemistry.org/Highlights/2006/30JanuaryB.shtm)
8.Zu,L.-S.;Wang,J.;Li,H.;Xie,H.-X.;Jiang,W.;Wang,W.“EnantioselectiveOrgancatalyticDominoMichael-AldolReactionsof????-UnsaturatedImides”,J.Am.Chem.Soc.,2007,129,1036.
9.Xie,H.-X.;Zu,L.-S.;Li,H.;Wang,J.;Wang,W.“OrganocatalyticEnantioselectiveCascadeMichael-AlkylationReactions.SynthesisofChiralCyclopropanesandInvestigationofUnexpectedOrganocatalyzedStereoselectiveRingOpeningofCyclopropanes”,J.Am.Chem.Soc.,2007,129,10886.
10.Wang,W.Li,H.;Wang,J.;Zu.L.-S.“EnantioselectiveOrgancatalyticTandemMichael-AldolReactions:One-PotSynthesisofChiralThiochromans”,J.Am.Chem.Soc.,2006,128,10354.
11.Zu,L.-S.;Li,H.;Xie,H.-X.;Wang,J.;Jiang,W.;Tang,Y.;Wang,W.“SynthesisofHighlyFunctionalizedChiralCyclopentanesbyCatalyticEnantio-andDiasterselectiveDoubleMichaelAddition”,Angew.Chem.Int.Ed.,2007,46,3732.
12.eFrutos,S.;Caldwell,E.;Nitta,C.H.;Kanagy,N.L.;Wang,J.;Wang,W.;Walker,M.K.;Bosc,L.V.G.“NFATc3ContributestoIntermittentHypoxia-InducedArterialRemodelinginMice”.AmericanJournalofPhysiology,2010,299,356-363.
13.Wang,L.;HuangJ.Y.;GongX.J.;Wang,J.*“HighlyRegioselectiveOrgaocatalyzedSynthesisofPyrazolesfromDiazoacetatesandCarbonylCompouds”,Chem.Eur.J.,2013,Inpress.
14.Wang,L.;Peng,S.Y.;Wang,J.*“Palladium-catalyzedcascadereactionsofcoumarinswithalkynes:synthesisofhighlysubstitutedcyclopentadienefusedchromones”Chem.Commun.,2011,47,5422–5424(Cover).
15.Gao,Y.J.;Ren,Q.;Wu,H.;Li,M.G.;Wang,J.*“Enantioselectiveheterocyclicsynthesisofspirochromanone–thiochromancomplexescatalyzedbyabifunctionalindanecatalyst”</span>Chem.Commun.,2010,46,9232–9234.
16.Gao,Y.J.;Ren,Q.;Wang,L.;Wang,J*&ldquo;EnantioselectiveSynthesisofCoumarinsCatalyzedbyaBifunctionalAmine–ThioureaCatalyst”Chem.Eur.J.,2010,16,13068–13071.
17.Ren,Q.;Gao,Y.J.;Wang,J.*“EnantioselectiveSynthesisofDenselyFunctionalizedPyranochromenesviaanUnpredictableCascadeMichael–Oxa-Michael–TautomerizationSequence”Chem.Eur.J.,2010,16,13594–13598.
18.Gao,Y.J.;Ren,Q.;Siau,W.-Y.;Wang,J.*“AsymmetricorganocatalyticcascadeMichael/hemiketalization/retro-Henryreactionof???-unsaturatedketoesterswith?-nitroketones”Chem.Commun.,2011,47,5819–5821.
19.Ren,Q.;Siau,W.-Y.;Du,Z.-Y.;Zhang,K.;Wang,J.*“ExpeditiousAssemblyofa2-Amino-4H-chromeneSkeletonbyUsinganEnantioselectiveMannichIntramolecularRingCyclization–TautomerizationCascadeSequence”Chem.Eur.J.,2011,17,7781–7785.
20.Danence,L.J.T.;Gao,Y.J.;Li,M.G.;Huang,Y.;Wang,J.*“OrganocatalyticEnamide–AzideCycloadditionReactions:RegiospecificSynthesisof1,4,5-Trisubstituted-1,2,3-Triazoles”Chem.Eur.J.2011,17,3584–3587.
21.Tan,H.R.;Ng,H.F.;Chang,J;Wang,J.*“HighlyEnantioselectiveAssemblyofFunctionalizedTetrahydroquinolineswithCreationofanAll-CarbonQuaternaryCenter”Chem.Eur.J.,2012,18,3865–3870.
22.Wang,L.;Peng,S.Y.;Danence,L.J.T.;Gao,Y.J.;Wang,J.*“Amine-Catalyzed[3+2]HuisgenCycloadditionStrategyfortheEfficientAssemblyofHighlySubstituted1,2,3-Triazoles”Chem.Eur.J.,2012,18,6088–6093.
23.Du,Z.Y.;Ren,C.L.;Ye,R.J.;Shen,J.;Maurizot,V.;Lu,Y.J.;Wang,J.;Zeng,H.Q.“BOP-mediatedone-potsynthesisofC5-symmetricmacrocyclicpyridinePentamers”Chem.Commun.,2011,47,12488–12490.
24.Siau,W.Y.;Li,W.J.;Xue,F.;Ren,Q.;Wu,M.H.;Sun,S.F.;Guo,H.B.;Jiang,X.F.;Wang,J.*“CatalyticandEnantioselectiveα-FunctionalizationofOxindolesThroughOxidativeReactionswithNaphthoquinones”Chem.Eur.J.,2012,18,9491–9495.
25.Li,W.J.;Liu,H.;Jiang,X.F.;Wang,J.</strong>*“EnantioselectiveOrganocatalyticconjugateAdditionofNitroalkanestoElectrophilic2-Iminochromenes”ACSCatal.2012,2,1535–1538.
26.Siau,W.Y.;Wang,J.*“Asymmetricorganocatalyticreactionsbybifunctionalamine-thioureas”Catal.Sci.Technol.,2011,1,1298–1310(InvitedReview)
27.Gao,Y.J.;Ren,Q.;Ang,S.M.;Wang,J*“EnantioselectiveorganocatalyticMichael-hemiketalizationcatalyzedbyatrans-bifunctionalindanethioureacatalyst”Org.Biomol.Chem.,2011,9,3691–3697.
28.Ren,Q.;Gao,Y.J.;Wang,J.*“ChiralindaneskeletonbasedthioureacatalyzedhighlystereoselectivecascadeMichael–enolation–cyclizationreaction”Org.Biomol.Chem.,2011,9,5297–5302.
29.Du,Z.Y.;Ng,H.F.;Zhang,K.;Zeng,H.Q.;Wang,J.*“IonicliquidmediatedCu-catalyzedcascadeoxa-Michael-oxidation:efficientsynthesisofflavonesundermildreactionconditions”Org.Biomol.Chem.,2011,9,6930–6933.
30.Du,Z.Y.;Siau,W.Y.;Wang,J.*“Enantioselectiveorganocatalyticsynthesisofmedicinallyprivileged2-amino-4H-chromene-3-carbonitrilesviaacascadeprocess”TetrahedronLetters2011,52,6137–6141.
31.Du,Z.Y.;Zhou,C.G.;Gao,Y.J.;Ren,Q.;Zhang,K.;Cheng,H.S.;Wang,W.;Wang,J.*“Expeditiousdiastereoselectiveconstructionofathiochromanskeletonviaacinchonaalkaloid-derivedcatalyst”Org.Biomol.Chem.,2012,10,36–39.
32.Peng,S.Y.;Wang,L.;Wang,J.*“Iron-catalyzedene-typepropargylationofdiarylethyleneswithpropargylAlcohols”Org.Biomol.Chem.,2012,10,225–228.
33.Peng,S.Y.;Wang,L.;Guo,H.B.;Sun,S.F.;Wang,J.*“Facilesynthesisof4-substituted3,4-dihydrocoumarinsviaanorganocatalyticdoubledecarboxylationprocess”Org.Biomol.Chem.,2012,10,2537–2541.
34.Zhang,N.;Agbor,L.N.;Scott,J.A.;Zalobowski,T.;Elased,K.M.;Trujillo,A.;Duke,M.S.;Wolf,V.;Walsh,M.T.;Born,J.L.;Felton,L.A.;Wang,J.;Wang,W.;Kanagy,N.L.;Walker,M.K.“AnActivatedRenin-angiotensinSystemMaintainsNormalBloodPressureinArylHydrocarbonReceptorHeterozygousMiceButNotInNullMice”,BiochemicalPharmacology,2010,80,197-204
35.Wang,J.;Li,H.;Liu,B.;Zu,L.-S.;Guo,H.;Wang,W.“Enantio-andDiastereoselectiveMichaelAdditionReactionsofUnmodifiedAldehydesandKetoneswithNitroolefinsCatalyzedbyaPyrrolidineSulfonamide”,Chem.-Eur.J.,2006,12,4321.
36.Wang,J.;Heikkinen,L.D.;Li,H.;Zu,L.-S.;Jiang,W.;Wang,W.“Quinine-CatalyzedEnantioselectiveMichaelAdditionofDiphenylPhosphitetoNitroolefins:SynthesisofChiralPrecursorsof??Substituted?-AminoPhosphonates”,Adv.Synth.Catal.,2007,349,1052.
37.Wang,J.;Li,H.;Zu,L.-S.;Wang,W.“HighlyEnantioselectiveOrganocatalyticMichaelAdditionReactionsofKetoneswithChalcones”,Adv.Synth.Catal.,2006,348,425.
38.Wang,J.;Li,H.;Zu,L.-S.;Wang,W.“OrganocatalyticEnantioselectiveConjugateAdditionofNitroalkanestoNitroolefins”,Adv.Synth.Catal.,2006,348,2047.
39.Wang,J.;Zu,L.-S.;Li,H.;Wang,W.“OrganocatalyticAsymmetricMichaelAdditionReactionsofHydrophosphitetoNitroolefins”,Adv.Synth.Catal.,2007,349,1052.
40.Wang,J.;Li,H.;Mei,Y.-J;Lou,B.-S;Xu,D.-G;Xie,D.-Q;Guo,H.;andWang,W.“<em>Direct,FacileAldehydeandKetone?-SelenenylationReactionsPromotedbyL-ProlinamideandPyrrolidineSulfonamideOrganocatalysts”,J.Org.Chem.,2005,70,5678.
41.Wang,J.;Li,H.;Zu,L.-S.;Wang,W.“EnantioselectiveOrganocatalyticMichaelAdditionReactionsbetweenN-heterocyclesandNitroolefins”,Org.Lett.,2006,7,1391.
42.Wang,J.;Li,H.;Yu,X.-H.;Zu,L.-S.;Wang,W.“ChiralBinaphthyl-DerivatedAmine-ThioureaOrganocatalyst-PromotedAsymmetricMorita-Baylis-HillmanReaction”,Org.Lett.,2005,7,4293.
43.Wang,J.;Li,H.;Duan,W.-H.;Zu,L.-S.;Wang,W.“OrganocatalyticAsymmetricMichaelAdditionof2,4-PentandionetoNitroolefins”,Org.Lett.,2005,7,4713.
44.Wang,J.;Li,H.;Wang,W.;“ASimpleandEfficientL-ProlinamideCatalyzed?-SelenenylationReactionsofAldehydes”,Org.Lett.,2004,6,2817.
45.Wang,J.;Zhang,M.-M.;Zhang,S.L.;Xu,Z.-A.;Li,H.;Yu,X.-H.;Wang,W.“ChiralPyrrolidineSulfonamideCatalyzedEnantioselectiveMichaelAdditionofCyclohexanonestoMaleimides”,Synlett.,2011,4,473-376.
46.Wang,J.;Zu,L.-S.;Li,H.;Xie,H.-X.;Jiang,W.Wang,W.“EnantioselectiveMichaelAdditionofN-HeterocyclestoEnonesCatalyzedbyaBifunctionalCinchonaAlkaloidThiourea”,Synthesis,2007,2576.
47.Zu,L.-S.;Wang,J.;Li,H.,Wang,W.“ARecyclableFluorous(S)-PyrrolidineSulfonamidePromotedDirectly,HighlyEnantioselectiveMichaelAdditionofKetonesandAldehydestoNitroolefinsinWater”,Org.Lett.,2006,8,3077.
48.Li,H.;Wang,J.;Xie,H.-X.;Zu,L.-S.;Jiang,W.;Duesler,E.N.;Wang,W.“ChiralDiphenylprolinolTESEtherPromotedConjugateAddition-Aldol-DehydrationReactionsbetween?????UnsaturatedAldehydesand2-N-ProtectedAminoBenzaldehydes”,Org.Lett.,2007,9,965.
49.Li,H.;Zu,L.-S.;Xie,H.-X.;Wang,J.;Wang,W.“HighlyEnantio-andDiastereoselectiveOrganocatalyticCascadeaza-Michael-MichaelReactions:aDirectMethodfortheSynthesisofTrisubstitutedChiralPyrrolidines”,Chem.Commun.,2008,43,5636-5638.
50.Zu,L.-S.;Xie,H.X.;Li,H.;Wang,J.;Yu,X.H.;Wang,W.“ChiralAmine-CatalyzedEnantioselectiveCascadeAza-ene-typeCyclizationReactions”,Chem.–Eur.J,2008,14,6333-6335.
51.Li,H.;Zu,L.-S.;Xie,H.X.;Wang,J.;Jiang,W.;Wang,W.“EnantioselectiveOrganocatalyticDoubleMichaelAddition”,Org.Lett.,2007,9,1833.
52.Zu,L.-S.;Xie,H.-X.;Li,H.;Wang,J.;Wang,W.“HighlyEnantioselectiveAldolReactionsCatalyzedbyaRecyclableFluorous(S)-PyrrolidineSulfonamideonWater”,Org.Lett.,2008,10,1211.
53.Xie,H.-X.;Zu,L.-S.;OueisH.-R.;Li,H.;Wang,J.;Wang,W.“Proline-CatalyzedDirectInverseElectronDemandDiels–AlderReactionsofKetoneswith1,2,4,5-Tetrazines”,Org.Lett.,2008,10,1923.
54.Zu,L.-S.;Xie,H.-X.;Li,H.;Wang,J.;Jiang,W.;Wang,W.*“AChiralAmineThioureaPromotedEnantioselectiveDominoMichael-AldolReactionsbetween2-Mercapto-benzaldehydesandMaleimides”,Adv.Synth.Catal.,2007,349,1882.
55.Zu,L.-S.;Xie,H.-X.;Li,H.;Wang,J.;Wang,W.“ThreeStepSynthesisofChrialBaclofenviaaHighlyEnantioselectiveOrganocatalyticConjugateAdditionofNitromethaneto????-UnsaturatedAldehydes”,Adv.Synth.Catal.,2007,349,2660.
56.Wang,W.;Li,H.;Wang,J.“Enantioselective,OrganocatalyticMukaiyama-MichaelAdditionofSilylEthersto????-UnsaturatedAldehydes”,Org.Lett.,2005,7,1637.
57.Wang,W.;Mei,Y.-J.;Li,H.;Wang,J.“ANovelPyrrolidineImideCatalyzedDirectFormationof?????UnsaturatedKetonesfromUnmodifiedKetonesandAldehydes”,Org.Lett.,2005,7,601.
58.Xie,H.-X.;Zu,L.-S.;OueisH.-R.;Li,H.;Wang,J.;Wang,W.“Proline-CatalyzedDirectInverseElectronDemandDiels–AlderReactionsofKetoneswith1,2,4,5-Tetrazines”,Org.Lett.,2008,10,1923.
59.Li,H.;Zu,L.-S.;Xie,H.-X.;Wang,J.;Wang,W.“HighlyEnantio-andDiastereoselectiveOrganocatalyticCascadeAza-Michael-MichaelReactions:ADirectMethodfortheSynthesisofTrisubstitutedChiralPyrrolidines”,Chem.Commun.,2008,43,5636.
60.Li,H.;Wang,J.;E-Nunu,T.;Zu,L.-S.;Jiang,W.;Wei,S.;Wang,W.“One-PotApproachtoChiralChromenesviaEnantioselectiveOrganocatalyticDominoOxa-Michael-AldolReaction”,Chem.Commun.,2007,507.
61.Wang,W.;Li,H.;Wang,J.“Enantioselective,OrganocatalyticMukaiyama-MichaelAdditionofSilylEthersto????-UnsaturatedAldehydes”,Org.Lett.,2005,7,1637.
62.Wang,W.;Mei,Y.-J.;Li,H.;Wang,J.“ANovelPyrrolidineImideCatalyzedDirectFormationof?????UnsaturatedKetonesfromUnmodifiedKetonesandAldehydes”,Org.Lett.,2005,7,601.
63.Wang,J.;Li,H.;Zu,L.-S.;Wang,W.“OrganocatalyticMichaelAdditionofN-HeterocyclestoNitroolefins”Synthesis,2008,tocontributetoPracticalSyntheticProcedures(PDS-Articles)inSynthesis.
64.Wang,W.;Wang,J.;Li,H.,Liao,L.-X.“ANovelAmineSulfonamideOrganocatalystforPromotingDirect?HighlyEnantioselective?-AminoxylationReactionsofAldehydesandKetones”,TetrahedronLett.,2004,45,7235.
65.Li,H.;Wang,J.;Zu,L.-S.;Wang,W.“OrganocatalyticAsymmetricConjugateAdditionofThioaceticAcidto?-Nitrostyrenes”,TetrahedronLett.,2006,47,2585.
66.Li,H.;Zu,L.-S.;Wang,J.;Wang,W.“OrganocatalyticEnantioselectiveMichaelAdditionofThioaceticAcidtoEnones”,TetrahedronLett.,2006,47,3145.
67.Zu,L.-S.;Li,H.;Wang,J.;Yu,X.H.;Wang,W.“HighlyEnantioselectiveAldehyde-NitroolefinMichaelAdditionReactionsCatalyzedbyRecyclableFluorous(S)-DiphenylPyrrolinolSilylEther&rdquo;,TetrahedronLett.,2006,47,5131.
68.Wang,W.;Li,H.;Wang,J.“PyrrolidineSulfonamidePromotedDirect,EnantioselectiveAldolReactionsof?????DialkylAldehydes:SynthesisofQuaternaryCarbon-Containing?-HydroxyCarbonylCompounds”,TetrahedronLett.,2005,46,5077.
69.Wang,W.;Li,H.;Wang,J.;Liao,L.-X.“Direct,Organocatalytic?-SulfenylationofAldehydesandKetones”,TetrahedronLett.,2004,45,8229.
70.Wang,J.;Xu,H.-J.;Shen,S.-Y.“SynthesisofPththalocyaninatocobalt(II)andComplexFormationwithImidazole”DyesandPigments,2000,45,59.
71.Wang,J.;Shen,S.-Y.;Xu,H.-J.“SynthesisandPropertiesofPththalocyaninatocobalt(II)Complex”PhotographicScienceandPhotochemistry,2000,18,179.
72.Wang,W.;Wang,J.;andLi,H.“OrganocatalystsandMethodsofUseinChemicalSynthesis”EUPatent,WO2006007586(2006).
73.Jiang,X.F.;Wang,J.;Qiao,R.;Liu,H.;ZhongguoFamingZhuanliShengqing,201210086826.5.
74.Jiang,X.F.;Wang,J.;Liu,H.;LiW.J.;ZhongguoFamingZhuanliShengqing,201210093045.9.
75.Jiang,X.F.;Wang,J.;Liu,H.;LiW.J.;ZhongguoFamingZhuanliShengqing,201210099868.2.
76.Jiang,X.F.;Wang,J.;Liu,H.;LiW.J.;ZhongguoFamingZhuanliShengqing,201210174908.5.