Qian,Feng

Me&Science:

Newmedicinedevelopmentisnotfragmentedintodiscretesubjects–itcrossesintodifferentscienceandengineeringsubjects.Utilizingandintegratingconceptsinphysics,chemistry,lifescience,andengineeringindrugproductinnovation,tounderstandtheactionmechanismofdrugproducts,andultimately,toconceptualizenoveltherapeutics,willbewhatwestrivetoachieve.

ResearchInterests:

Pharmaceutics,DrugDeliverySystems

ScientificFocus:

Drug-polymersystemsforthedeliveryofpoorlywatersolubledrugcandidates

Tuberculosistargeteddrugdeliverysystems

Thephysicalaspectsofproteinformulation,suchasviscosity,self-aggregation,protein-excipientinteraction

Novelformulationtechnologies,andtheirapplicationindrugproductdevelopmentandoptimization

ResearchKeywords:

drugdeliverysystems,proteinformulation,solubilityenhancement

ProfessionalOverview:

• 2013AAPSPharmSciTech,EditorialAdvisoryBoard(EAB),fromJanuary1,2013
• 2012“1000TalentRecruitmentProgram”(CategoryC:YouthGroup),Chinesegovernment
• 2011GraduateFaculty,DepartmentofIndustrial&PhysicalPharmacy,PurdueUniversity(IN,USA)
• 2007“ChemistryLeadershipAward”,Bristol-MyersSquibbCompany
• 2003-2012PrincipalScientist,DrugProductScienceandTechnology,Bristol-MyersSquibbCompany,NewBrunswick,NJ
• 1998-2003Ph.D.,BiomedicalEngineering,CaseWesternReserveUniversity,Cleveland,OH
• 1990-1998M.S.andundergraduatestudy,MaterialsScience&Engineering,TsinghuaUniversity,Beijing,China
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SelectedPublications:

Qian,F.*;Wang,J.;Hartley,R.;Tao,J.;Haddadin,R.;Mathias,N..;Hussain,M.SolutionBehaviorofPVP-VAandHPMC-ASBasedAmorphousSolidDispersionsandTheirBioavailabilityImplications,PharmaceuticalResearch,2012,publishedonline:DOI10.1007/s11095-012-0695-7

Qian,F.*;Huang,J.;Zhu,Q.;Haddadin,R.;Gawel,J.;Garmise,R.;Hussain,M.IsaDistinctiveSingleTgaReliableIndicatorfortheHomogeneityofAmorphousSolidDispersion?InternationalJournalofPharmaceutics,Volume395,Issues1-2,16August2010,Pages232-235

Qian,F.;Huang,J.;Hussain,M.Drug-polymersolubilityandmiscibility:stabilityconsiderationandpracticalchallengesinamorphoussoliddispersiondevelopment.JournalofPharmaceuticalSciences,2010,99(7),2941-2947

Qian,F.*;Ni,N.;Burton,L.;Wang,F.;Desikan,S.;Hussain,M.;Smith,RL.SustainedReleaseSubcutaneousDeliveryofBMS-686117,aGLP-1ReceptorAgonist,ViaZincAdduct.InternationalJournalofPharmaceutics,Vol.374,Issues1-2,5June2009,46-52

Qian,F.*;Moench,P.;Mathias,N.;Desikan,S.;Hussain,M.;Smith,RL.PulmonaryDeliveryofaGLP-1ReceptorAgonist,BMS-686117.InternationalJournalofPharmaceutics,Vol.366,2009,218–220

Qian,F.*;Ni,N.;Chen,JW.;Desikan,S.;Naringrekar,V.;Hussain,M.;Smith,RL.FormationofZincPeptideSphericalMicroparticlesduringLyophilizationFromtert-ButylAlcohol/WatercosolventSystem.PharmaceuticalResearch,Vol.25,No.12,December2008

Qian,F.*;Tao,J..;Desikan,S.;Hussain,M.;Smith,RL.MechanisticInvestigationofPluronic?BasedNano-crystallineSolidDispersion.PharmaceuticalResearch,2007,24(8):1551-60.

Qian,F.;Stowe,N.;SaidelG.;Gao,J.ComparisonofDoxorubicinConcentrationProfilesinRFAblatedRatLiversfromSustainedandDual-releasePLGAMillirods.PharmaceuticalResearch.2004,21(3),394-9.

Qian,F.;Stowe,N.;Liu,E.H.;SaidelG.;Gao,J.QuantificationofInVivoDoxorubicinTransportinThermoablatedRatLiversfromPLGAMillirods.JournalofControlledRelease.2003,91(1-2),157-66.

Qian,F.;SaidelG.;Sutton,D.;Exner,A.;Gao,J.CombinedModelingandExperimentalApproachfortheDevelopmentofDual-releasePolymerMillirods.JournalofControlledRelease.2002,83(3),427-435.

Qian,F.;Nasongkla,N.;Gao,J.Membrane-encasedPolymerMillirodsforSustainedReleaseof5-Fluorouracil.JournalofBiomedicalMaterialsResearch,2002,61(2),203-11.

Qian,F.;Szymanski,A.;Gao,J.FabricationandCharacterizationofControlledReleasePoly(D,L-Lactide-co-Glycolide)Millirods.JournalofBiomedicalMaterialsResearch,2001,55(4),512-522.