) 1河南大学认知、脑与健康研究所, 教育科学学院, 河南省心理与行为研究所, 开封 475004
2新乡医学院第二附属医院, 河南省精神病医院, 新乡 453002
3河南省生物精神病学重点实验室, 新乡医学院, 新乡 453002
收稿日期:2020-11-09发布日期:2021-04-25通讯作者:王慧颖E-mail:wanghuiyingwing@foxmail.com基金资助:教育部人文社会科学研究项目(20YJC190019);河南省生物精神病学重点实验室开放课题(ZDSYS2019009);河南省医学科技攻关计划联合共建项目(2018020375)Propranolol rescued secondary trauma induced by immediate extinction
WANG Hongbo1, XING Xiaoli1, WANG Huiying2,3() 1Institute of Cognition, Brain and Health; School of Educational Science; Henan Key Lab of Psychology and Behavior, Henan University, Kaifeng 475004, China
2Henan Mental Hospital, the Second Affiliated Hospital of Xinxiang Medical University, Xinxiang 453002, China
3Henan Key Lab of Biological Psychiatry, Xinxiang Medical University, Xinxiang 453002, China
Received:2020-11-09Published:2021-04-25Contact:WANG Huiying E-mail:wanghuiyingwing@foxmail.com摘要/Abstract
摘要： 恐惧消退能力的受损是创伤后应激障碍(posttraumatic stress disorder, PTSD)的标志之一。以往的研究表明, 相较于延迟消退, 恐惧获得后短时间内进行的消退训练不能形成长时程的消退记忆, 这一现象被称为即刻消退缺损。然而, 目前并不清楚这种缺损是一次性的, 还是会继续影响其后的重消退。实验1中, 大鼠在恐惧习得后1小时(即刻消退)或24小时(延迟消退)开始进行消退训练, 24小时后进行重消退, 再24小时后进行消退记忆的测试。结果显示, 与延迟消退相比, 即刻消退效果缺损, 并引起第二天的重消退也出现效果缺损。实验2中, 恐惧获得后立即给予大鼠盐水或β-肾上腺素受体阻断剂普萘洛尔(10 mg/kg, i.p.), 然后测试即刻消退和重消退的效果。结果显示, 普萘洛尔虽没有阻止即刻消退的缺损, 但避免了重消退出现缺损。总之, 严重创伤后的即刻消退不但无法有效抑制恐惧反应, 还可能造成二次创伤, 会损害恐惧消退能力, 而普萘洛尔可修复即刻消退引起的重消退缺损。这些结果将有助于我们加深对PTSD病理机制和早期干预后果的认识。
图/表 2
图1即刻消退引发重消退效果缺损 注: **p < 0.01, #p = 0.06误差线为标准误(SE)
图1即刻消退引发重消退效果缺损 注: **p < 0.01, #p = 0.06误差线为标准误(SE) 
图2普萘洛尔修复即刻消退引发的重消退缺损 注: **p < 0.01, ***p < 0.001, 误差线为标准误( SE)
图2普萘洛尔修复即刻消退引发的重消退缺损 注: **p < 0.01, ***p < 0.001, 误差线为标准误( SE) 参考文献 46
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