删除或更新信息，请邮件至freekaoyan#163.com(#换成@)

自闭症谱系障碍个体的疼痛敏感性异常：来自元分析的证据

本站小编 Free考研考试/2022-01-01
张文芸, 李晓云, 姚俊杰, 叶倩, 彭微微()
深圳大学心理学院, 深圳 518060
收稿日期:2020-09-21发布日期:2021-04-25
通讯作者:彭微微E-mail:ww.peng0923@gmail.com

基金资助:国家自然科学基金(31871127);广东省普通高校特色创新类项目(2019KTSCX149);深圳市基础研究自由探索项目(JCYJ20190808154413592)

Abnormalities in pain sensitivity among individuals with autism spectrum disorder: Evidence from meta-analysis

ZHANG Wenyun, LI Xiaoyun, YAO Junjie, YE Qian, PENG Weiwei()
School of Psychology, Shenzhen University, Shenzhen 518060, China
Received:2020-09-21Published:2021-04-25
Contact:PENG Weiwei E-mail:ww.peng0923@gmail.com






摘要/Abstract


摘要： 本研究采用元分析方法, 以疼痛阈限、疼痛诱发生理反应和疼痛评分为结果变量, 考察了自闭症谱系障碍个体(Autism Spectrum Disorder, ASD)的疼痛敏感性异常, 以期为ASD的诊断和干预提供参考。元分析共纳入16项研究(总样本量N = 822)。对于疼痛阈限, ASD组和对照组无显著差异, 但受到疼痛模态等变量的调节作用, 如ASD组的压力疼痛阈限显著低于对照组。对于疼痛诱发生理反应, ASD组对现实医疗疼痛的生理反应强于对照组。然而, ASD组和对照组在疼痛评分上无显著差异。将来研究应结合多模态疼痛刺激和多维度疼痛评估, 系统考察ASD个体的疼痛敏感性及其与临床核心症状之间的联系。



图1文献检索过程及纳入与排除流程图
图1文献检索过程及纳入与排除流程图


表1纳入元分析的研究的相关信息(16篇)
研究 ASD组样本量
及年龄(岁) 		对照组样本量
及年龄(岁) 		刺激模态 刺激位置 疼痛测量
指标 		地区 主要结果
Fan et al. 2014 n = 24
年龄：18.4 ± 2.8 		n = 21
年龄：19.3 ± 3.4 		压力疼痛 左右手(食指背侧
近端指骨) 		疼痛阈限 亚洲 ASD低疼痛阈限,
高疼痛敏感性↑
Chen et al.
2017 		n = 37
年龄：18.2 ± 5.2 		n = 34
年龄：19.3 ± 4.6 		压力疼痛 左右手(食指背侧
近端指骨) 		疼痛阈限 亚洲 ASD低疼痛阈限,
高疼痛敏感性↑
Riquelme et al. 2016 n = 27
年龄：6.3 ± 3.2 		n = 30
年龄：6.5 ± 3.4 		压力疼痛 脸、手背和手掌 疼痛阈限 欧洲 ASD低疼痛阈限,
高疼痛敏感性↑
Chien et al.
2017 		n = 31
年龄：20.5 ± 5.2 		n = 22
年龄：21.4 ± 2.6 		热痛 腿(外侧) 疼痛评分 亚洲 无显著差异?
Failla et al.
2018 		n = 15
年龄：27.5 ± 10.3 		n = 16
年龄：30.1 ± 10.9 		热痛 腿(外侧) 疼痛阈限
疼痛评分 		美洲 无显著差异?
Dubois et al. 2020 n = 19
年龄：31.5 ± 8.5 		n = 19
年龄：31.6 ± 8.4 		热痛 手臂 疼痛评分 欧洲 无显著差异?
Cascio et al. 2008 n = 8
年龄：29.3 ± 10.5 		n = 8
年龄：29.0 ± 9.7 		冷痛
热痛 		前臂
手掌 		疼痛阈限 美洲 ASD低疼痛阈限,
高疼痛敏感性↑
Duerden et al. 2015 n = 20
年龄：14.6 ± 1.9 		n = 55
年龄：15.7 ± 1.1 		冷痛
热痛 		前臂 疼痛阈限 美洲 无显著差异?
Bird et al.
2010 		n = 18
年龄：34.6 ± 13.3 		n = 18
年龄：35 ± 12.8 		电刺激疼痛 手背 疼痛阈限 欧洲 无显著差异?
Thaler et al. 2018 n = 16
年龄：25.5 ± 5.4 		n = 16
年龄：24.5 ± 2.7 		电刺激疼痛 手背 疼痛阈限
疼痛评分 		欧洲 无显著差异?
李晋 等, 2015 n = 70
年龄：2~8 		n = 71
年龄：2~8 		电刺激疼痛 前臂 疼痛阈限 亚洲 ASD高疼痛阈限,
低疼痛敏感性↓
Yasuda et al. 2016 n = 15
年龄：25.8 ± 9.2 		n = 15
年龄：26.3 ± 7.5 		冷痛
热痛
电刺激疼痛 		前臂 疼痛阈限
耐受阈限
疼痛评分 		亚洲 疼痛阈限和耐受阈限：
无显著差异?
疼痛评分：
ASD低疼痛评分↓
Fründtet al. 2017 n = 13
年龄：31.7 ± 8.2 		n = 13
年龄：32.1 ± 7.1 		冷痛
热痛
压力疼痛
机械疼痛 		左右手背 疼痛阈限 欧洲 无显著差异?
Vaughan et al. 2019 n = 13
年龄：27.2 ± 9.2 		n = 13
年龄：27.1 ± 8.1 		冷痛
热痛
冷水压痛
机械疼痛
压力疼痛 		手掌(压痛)
手部(冷水压痛)
手、脚和脸均值
(其他剩余模态) 		疼痛阈限
耐受阈限
(冷压痛) 		美洲 无显著差异?
Tordjman et al. 2009 n = 63
年龄：11.7 ± 4.5 		n = 11
年龄：12.7 ± 5.9 		静脉穿刺 手臂 生理反应
(心率) 		欧洲 ASD生理反应强烈↑,
心率变化大
Rattaz et al.
2013 		n = 35
年龄：4.8 		n = 36
年龄：3.7 		静脉穿刺 手臂 生理反应
(心率) 		欧洲 ASD生理反应强烈↑,
心率变化大
李晋 等, 2015 n = 68
年龄：2~8 		n = 64
年龄：2~8 		静脉穿刺 手臂 生理反应
(心率) 		亚洲 ASD生理反应强烈↑,
心率变化大

表1纳入元分析的研究的相关信息(16篇)
研究 ASD组样本量
及年龄(岁) 		对照组样本量
及年龄(岁) 		刺激模态 刺激位置 疼痛测量
指标 		地区 主要结果
Fan et al. 2014 n = 24
年龄：18.4 ± 2.8 		n = 21
年龄：19.3 ± 3.4 		压力疼痛 左右手(食指背侧
近端指骨) 		疼痛阈限 亚洲 ASD低疼痛阈限,
高疼痛敏感性↑
Chen et al.
2017 		n = 37
年龄：18.2 ± 5.2 		n = 34
年龄：19.3 ± 4.6 		压力疼痛 左右手(食指背侧
近端指骨) 		疼痛阈限 亚洲 ASD低疼痛阈限,
高疼痛敏感性↑
Riquelme et al. 2016 n = 27
年龄：6.3 ± 3.2 		n = 30
年龄：6.5 ± 3.4 		压力疼痛 脸、手背和手掌 疼痛阈限 欧洲 ASD低疼痛阈限,
高疼痛敏感性↑
Chien et al.
2017 		n = 31
年龄：20.5 ± 5.2 		n = 22
年龄：21.4 ± 2.6 		热痛 腿(外侧) 疼痛评分 亚洲 无显著差异?
Failla et al.
2018 		n = 15
年龄：27.5 ± 10.3 		n = 16
年龄：30.1 ± 10.9 		热痛 腿(外侧) 疼痛阈限
疼痛评分 		美洲 无显著差异?
Dubois et al. 2020 n = 19
年龄：31.5 ± 8.5 		n = 19
年龄：31.6 ± 8.4 		热痛 手臂 疼痛评分 欧洲 无显著差异?
Cascio et al. 2008 n = 8
年龄：29.3 ± 10.5 		n = 8
年龄：29.0 ± 9.7 		冷痛
热痛 		前臂
手掌 		疼痛阈限 美洲 ASD低疼痛阈限,
高疼痛敏感性↑
Duerden et al. 2015 n = 20
年龄：14.6 ± 1.9 		n = 55
年龄：15.7 ± 1.1 		冷痛
热痛 		前臂 疼痛阈限 美洲 无显著差异?
Bird et al.
2010 		n = 18
年龄：34.6 ± 13.3 		n = 18
年龄：35 ± 12.8 		电刺激疼痛 手背 疼痛阈限 欧洲 无显著差异?
Thaler et al. 2018 n = 16
年龄：25.5 ± 5.4 		n = 16
年龄：24.5 ± 2.7 		电刺激疼痛 手背 疼痛阈限
疼痛评分 		欧洲 无显著差异?
李晋 等, 2015 n = 70
年龄：2~8 		n = 71
年龄：2~8 		电刺激疼痛 前臂 疼痛阈限 亚洲 ASD高疼痛阈限,
低疼痛敏感性↓
Yasuda et al. 2016 n = 15
年龄：25.8 ± 9.2 		n = 15
年龄：26.3 ± 7.5 		冷痛
热痛
电刺激疼痛 		前臂 疼痛阈限
耐受阈限
疼痛评分 		亚洲 疼痛阈限和耐受阈限：
无显著差异?
疼痛评分：
ASD低疼痛评分↓
Fründtet al. 2017 n = 13
年龄：31.7 ± 8.2 		n = 13
年龄：32.1 ± 7.1 		冷痛
热痛
压力疼痛
机械疼痛 		左右手背 疼痛阈限 欧洲 无显著差异?
Vaughan et al. 2019 n = 13
年龄：27.2 ± 9.2 		n = 13
年龄：27.1 ± 8.1 		冷痛
热痛
冷水压痛
机械疼痛
压力疼痛 		手掌(压痛)
手部(冷水压痛)
手、脚和脸均值
(其他剩余模态) 		疼痛阈限
耐受阈限
(冷压痛) 		美洲 无显著差异?
Tordjman et al. 2009 n = 63
年龄：11.7 ± 4.5 		n = 11
年龄：12.7 ± 5.9 		静脉穿刺 手臂 生理反应
(心率) 		欧洲 ASD生理反应强烈↑,
心率变化大
Rattaz et al.
2013 		n = 35
年龄：4.8 		n = 36
年龄：3.7 		静脉穿刺 手臂 生理反应
(心率) 		欧洲 ASD生理反应强烈↑,
心率变化大
李晋 等, 2015 n = 68
年龄：2~8 		n = 64
年龄：2~8 		静脉穿刺 手臂 生理反应
(心率) 		亚洲 ASD生理反应强烈↑,
心率变化大



图2疼痛阈限森林图
图2疼痛阈限森林图



图3疼痛评分森林图
图3疼痛评分森林图



图4疼痛诱发生理反应森林图
图4疼痛诱发生理反应森林图


表2ASD疼痛耐受阈限文章相关信息
研究 样本量 刺激模态 ASD 个体 普通个体 p
Yasuda et al. 2016 15 vs 15 接触式冷痛 2.50 ± 7.22 ℃ 3.74 ± 11.24 ℃ 0.66
接触式热痛 46.12 ± 2.23 ℃ 46.35 ± 3.16 ℃ 0.66
电刺激疼痛 104.48 ± 52.23 μA 92.86 ± 55.99 μA 0.47
Vaughan et al. 2019 13 vs 13 冷压痛 37.28 ± 45.49 s 28.24 ± 17.87 s 0.51

表2ASD疼痛耐受阈限文章相关信息
研究 样本量 刺激模态 ASD 个体 普通个体 p
Yasuda et al. 2016 15 vs 15 接触式冷痛 2.50 ± 7.22 ℃ 3.74 ± 11.24 ℃ 0.66
接触式热痛 46.12 ± 2.23 ℃ 46.35 ± 3.16 ℃ 0.66
电刺激疼痛 104.48 ± 52.23 μA 92.86 ± 55.99 μA 0.47
Vaughan et al. 2019 13 vs 13 冷压痛 37.28 ± 45.49 s 28.24 ± 17.87 s 0.51


表3调节变量随机模型分析
调节变量 同质性分析 类别 独立样本 效应值及95%置信区间 双侧检验
p
QB df p 点估计 下限 上限
刺激模态 10.90 4 p< 0.05 冷痛 6 0.17 -0.16 0.51 0.31
热痛 6 -0.05 -0.58 0.49 0.86
压力痛 5 1.62 0.46 2.77 0.006
机械痛 2 -0.43 -0.98 0.12 0.13
电刺激疼痛 4 -0.27 -1.37 0.82 0.63
刺激位置 3.46 3 0.33 手部 10 0.41 -0.24 1.06 0.22
手臂 6 0.78 -0.34 2.2 0.43
腿部 1 0.22 -0.98 0.42 0.54
多部位均值 6 0.93 -0.49 0.93 0.15
ASD组样本量 79.26 3 p< 0.001 n ≤ 10 2 1.54 0.72 2.36 p< 0.001
10 < n≤ 20 16 -0.04 -0.24 0.15 0.65
20 < n≤ 50 4 1.86 0.39 3.33 0.01
n> 50 1 -1.61 -1.99 -1.23 p< 0.001
被试群体 6.90 3 0.08 儿童 2 0.81 -3.94 5.55 0.74
青少年 2 -0.28 -0.64 0.09 0.14
青少年与成人 6 0.89 0.06 1.72 0.04
成人 13 0.07 -0.26 0.40 0.66
地区 0.44 2 0.80 亚洲 6 0.57 -0.81 1.96 0.42
美洲 10 0.14 -0.25 0.53 0.48
欧洲 7 0.33 -0.58 1.23 0.48

表3调节变量随机模型分析
调节变量 同质性分析 类别 独立样本 效应值及95%置信区间 双侧检验
p
QB df p 点估计 下限 上限
刺激模态 10.90 4 p< 0.05 冷痛 6 0.17 -0.16 0.51 0.31
热痛 6 -0.05 -0.58 0.49 0.86
压力痛 5 1.62 0.46 2.77 0.006
机械痛 2 -0.43 -0.98 0.12 0.13
电刺激疼痛 4 -0.27 -1.37 0.82 0.63
刺激位置 3.46 3 0.33 手部 10 0.41 -0.24 1.06 0.22
手臂 6 0.78 -0.34 2.2 0.43
腿部 1 0.22 -0.98 0.42 0.54
多部位均值 6 0.93 -0.49 0.93 0.15
ASD组样本量 79.26 3 p< 0.001 n ≤ 10 2 1.54 0.72 2.36 p< 0.001
10 < n≤ 20 16 -0.04 -0.24 0.15 0.65
20 < n≤ 50 4 1.86 0.39 3.33 0.01
n> 50 1 -1.61 -1.99 -1.23 p< 0.001
被试群体 6.90 3 0.08 儿童 2 0.81 -3.94 5.55 0.74
青少年 2 -0.28 -0.64 0.09 0.14
青少年与成人 6 0.89 0.06 1.72 0.04
成人 13 0.07 -0.26 0.40 0.66
地区 0.44 2 0.80 亚洲 6 0.57 -0.81 1.96 0.42
美洲 10 0.14 -0.25 0.53 0.48
欧洲 7 0.33 -0.58 1.23 0.48







*为纳入元分析文献
[1] Allely, C.S. (2013). Pain sensitivity and observer perception of pain in individuals with autistic spectrum disorder. Scientific World Journal, 2013,916178.
[2] American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (DSM-5?). American Psychiatric Pub.
[3] Arendt-Nielsen, L., & Yarnitsky, D. (2009). Experimental and clinical applications of quantitative sensory testing applied to skin, muscles and viscera. Journal of Pain, 10(6),556-572.
doi: 10.1016/j.jpain.2009.02.002pmid: 19380256
[4] Bailey, A., Phillips, W., & Rutter, M. (1996). Autism: Towards an integration of clinical, genetic, neuropsychological, and neurobiological perspectives. Journal of Child Psychology and Psychiatry, 37(1),89-126.
pmid: 8655659
[5] Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The autism-spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31(1),5-17.
pmid: 11439754
[6] Begeer, S., Koot, H.M., Rieffe, C., Meerum Terwogt, M., & Stegge, H. (2008). Emotional competence in children with autism: Diagnostic criteria and empirical evidence. Developmental Review, 28(3),342-369.
doi: 10.1016/j.dr.2007.09.001URL
[7] * Bird, G., Silani, G., Brindley, R., White, S., Frith, U., & Singer, T. (2010). Empathic brain responses in insula are modulated by levels of alexithymia but not autism. Brain, 133(5),1515-1525.
doi: 10.1093/brain/awq060URL
[8] Borenstein, M. (2009). Effect sizes for continuous data. In H. Cooper, L. V. Hedges, & J. C. Valentine (Eds.), The handbook of research synthesis and meta-analysis (p. 221-235), Russell Sage Foundation.
[9] Boyd, B.A., Baranek, G.T., Sideris, J., Poe, M.D., Watson, L.R., Patten, E., & Miller, H. (2010). Sensory features and repetitive behaviors in children with autism and developmental delays. Autism Research, 3(2),78-87.
[10] Bushnell, M.C., Ceko, M., & Low, L.A. (2013). Cognitive and emotional control of pain and its disruption in chronic pain. Nature Reviews Neuroscience, 14(7),502-511.
doi: 10.1038/nrn3516URL
[11] * Cascio, C., McGlone, F., Folger, S., Tannan, V., Baranek, G., Pelphrey, K.A., & Essick, G. (2008). Tactile perception in adults with autism: A multidimensional psychophysical study. Journal of Autism and Developmental Disorders, 38(1),127-137.
doi: 10.1007/s10803-007-0370-8URL
[12] * Chen, C., Hung, A.Y., Fan, Y.T., Tan, S., Hong, H., & Cheng, Y. (2017). Linkage between pain sensitivity and empathic response in adolescents with autism spectrum conditions and conduct disorder symptoms. Autism Research, 10(2),267-275.
doi: 10.1002/aur.1653URL
[13] Chen, Y.H., Rodgers, J., & McConachie, H. (2009). Restricted and repetitive behaviours, sensory processing and cognitive style in children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(4),635-642.
doi: 10.1007/s10803-008-0663-6URL
[14] * Chien, Y.L., Wu, S.W., Chu, C.P., Hsieh, S.T., Chao, C.C., & Gau, S.S. (2017). Attenuated contact heat-evoked potentials associated with sensory and social-emotional symptoms in individuals with autism spectrum disorder. Scientific Reports, 7,36887.
doi: 10.1038/srep36887URL
[15] Coghill, R.C., Sang, C.N., Maisog, J.M., & Iadarola, M.J. (1999). Pain intensity processing within the human brain: A bilateral, distributed mechanism. Journal of Neurophysiology, 82(4),1934-1943.
doi: 10.1152/jn.1999.82.4.1934URL
[16] Cooper, H.M. (1989). Integrating research: A guide for literature reviews. Sage Publications, Inc.
[17] Decety, J., & Svetlova, M. (2012). Putting together phylogenetic and ontogenetic perspectives on empathy. Developmental Cognitive Neuroscience, 2(1),1-24.
doi: 10.1016/j.dcn.2011.05.003pmid: 22682726
[18] * Dubois, A., Boudjarane, M., Le Fur-Bonnabesse, A., Dion, A., L'Heveder, G., Quinio, B.,... Bodéré, C. (2020). Pain modulation mechanisms in ASD adults. Journal of Autism and Developmental Disorders, 50,2931-2940.
doi: 10.1007/s10803-019-04361-xpmid: 32040798
[19] * Duerden, E.G., Taylor, M.J., Lee, M., McGrath, P.A., Davis, K.D., & Roberts, S.W. (2015). Decreased sensitivity to thermal stimuli in adolescents with autism spectrum disorder: Relation to symptomatology and cognitive ability. Journal of Pain, 16(5),463-471.
doi: 10.1016/j.jpain.2015.02.001pmid: 25704841
[20] Egger, M., Smith, G.D., Schneider, M., & Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. British Medical Journal, 315(7109),629-634.
doi: 10.1136/bmj.315.7109.629URL
[21] * Failla, M.D., Moana-Filho, E.J., Essick, G.K., Baranek, G.T., Rogers, B.P., & Cascio, C.J. (2018). Initially intact neural responses to pain in autism are diminished during sustained pain. Autism, 22(6),669-683.
doi: 10.1177/1362361317696043URL
[22] Failla, M., Davis, S., Gerdes, M., Williams, Z., Moore, D., & Cascio, C. (2019). Increased heat pain sensitivity and pain-related anxiety in individuals with autism. Journal of Pain, 20(4),S40.
doi: 10.1016/j.jpain.2019.01.184
[23] Fan, Y., & Han, S. (2008). Temporal dynamic of neural mechanisms involved in empathy for pain: An event-related brain potential study. Neuropsychologia, 46(1),160-173.
doi: 10.1016/j.neuropsychologia.2007.07.023URL
[24] * Fan, Y.T., Chen, C., Chen, S.C., Decety, J., & Cheng, Y. (2014). Empathic arousal and social understanding in individuals with autism: Evidence from fMRI and ERP measurements. Social Cognitive and Affective Neuroscience, 9(8),1203-1213.
doi: 10.1093/scan/nst101URL
[25] Faul, F., Erdfelder, E., Lang, A.G., & Buchner, A. (2007). G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behavior Research Methods, 39(2),175-191.
doi: 10.3758/BF03193146URL
[26] Fitzgibbon, B.M., Segrave, R.A., Fitzgerald, P.B., & Enticott, P.G. (2013). Can studies of pain help to bridge the gap between sensory and social impairments in autism? Frontiers in Human Neuroscience, 7,2.
[27] Foss-Feig, J.H., Heacock, J.L., & Cascio, C.J. (2012). Tactile responsiveness patterns and their association with core features in autism spectrum disorders. Research in Autism Spectrum Disorders, 6(1),337-344.
pmid: 22059092
[28] * Fründt, O., Grashorn, W., Sch?ttle, D., Peiker, I., David, N., Engel, A.K.,... Bingel, U. (2017). Quantitative sensory testing in adults with autism spectrum disorders. Journal of Autism and Developmental Disorders, 47(4),1183-1192.
doi: 10.1007/s10803-017-3041-4URL
[29] Gillberg, C., & Coleman, M. (2000). The biology of the autistic syndromes. Cambridge University Press.
[30] Gu, X., & Han, S. (2007). Attention and reality constraints on the neural processes of empathy for pain. NeuroImage, 36(1),256-267.
doi: 10.1016/j.neuroimage.2007.02.025URL
[31] Gu, X., Zhou, T.J., Anagnostou, E., Soorya, L., Kolevzon, A., Hof, P.R., & Fan, J. (2018). Heightened brain response to pain anticipation in high-functioning adults with autism spectrum disorder. European Journal of Neuroscience, 47(6),592-601.
doi: 10.1111/ejn.13598URL
[32] Guan, J., & Zhao, X. (2015). Sub-threshold autistic traits in normal population: Its concept, structure and influencing factors. Advances in Psychological Science, 23(9),1599-1607.
doi: 10.3724/SP.J.1042.2015.01599URL
[ 关荐, 赵旭东. (2015). 基于正常人群的阈下自闭特质: 概念、结构和影响因素. 心理科学进展>, 23(9),1599-1607.]
[33] Han, Q., Kim, Y.H., Wang, X., Liu, D., Zhang, Z.J., Bey, A.L.,... Ji, R.R. (2016). SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons. Neuron, 92(6),1279-1293.
doi: 10.1016/j.neuron.2016.11.007URL
[34] Hill, E., Berthoz, S., & Frith, U. (2004). Brief report: Cognitive processing of own emotions in individuals with autistic spectrum disorder and in their relatives. Journal of Autism and Developmental Disorders, 34(2),229-235.
[35] Hoekstra, R.A., Vinkhuyzen, A.A., Wheelwright, S., Bartels, M., Boomsma, D.I., Baron-Cohen, S.,... van der Sluis, S. (2011). The construction and validation of an abridged version of the autism-spectrum quotient (AQ-Short). Journal of Autism and Developmental Disorders, 41(5),589-596.
doi: 10.1007/s10803-010-1073-0pmid: 20697795
[36] Huedo-Medina, T.B., Sánchez-Meca, J., Marín-Martínez, F., & Botella, J. (2006). Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychological Methods, 11(2),193-206.
pmid: 16784338
[37] Ingersoll, B., Schreibman, L., & Tran, Q.H. (2003). Effect of sensory feedback on immediate object imitation in children with autism. Journal of Autism and Developmental Disorders, 33(6),673-683.
pmid: 14714935
[38] Joosten, A.V., & Bundy, A.C. (2010). Sensory processing and stereotypical and repetitive behaviour in children with autism and intellectual disability. Australian Occupational Therapy Journal, 57(6),366-372.
doi: 10.1111/aot.2010.57.issue-6URL
[39] Kim, H.J., Yang, G.S., Greenspan, J.D., Downton, K.D., Griffith, K.A., Renn, C.L.,... Dorsey, S.G. (2017). Racial and ethnic differences in experimental pain sensitivity: Systematic review and meta-analysis. Pain, 158(2),194-211.
doi: 10.1097/j.pain.0000000000000731URL
[40] Klintwall, L., Holm, A., Eriksson, M., Carlsson, L.H., Olsson, M.B., Hedvall, ?.,... Fernell, E. (2011). Sensory abnormalities in autism: A brief report. Research in Developmental Disabilities, 32(2),795-800.
[41] Koga, K., Furue, H., Rashid, M.H., Takaki, A., Katafuchi, T., & Yoshimura, M. (2005). Selective activation of primary afferent fibers evaluated by sine-wave electrical stimulation. Molecular Pain, 1,13.
[42] Kong, J., White, N.S., Kwong, K.K., Vangel, M.G., Rosman, I.S., Gracely, R.H., & Gollub, R.L. (2006). Using fMRI to dissociate sensory encoding from cognitive evaluation of heat pain intensity. Human Brain Mapping, 27(9),715-721.
doi: 10.1002/(ISSN)1097-0193URL
[43] Kuperman, P., Granovsky, Y., Bahouth, H., Fadel, S., Ben Lulu, H., Bosak, N.,... Granot, M. (2020). Explaining very early acute mild traumatic brain injury after motor vehicle collision pain variability: Additive value of pain sensitivity questionnaire. Pain Reports, 5(3),e821.
[44] Leekam, S.R., Nieto, C., Libby, S.J., Wing, L., & Gould, J. (2007). Describing the sensory abnormalities of children and adults with autism. Journal of Autism and Developmental Disorders, 37(5),894-910.
pmid: 17016677
[45] Li, J., Song, T., Meng, F., Li, H., Dai, Y., Han, S., Han, J. (2015). Pain threshold in children with autism and age-matched typically developed children: A comparative study. Chinese Journal of Pain Medicine, 21(12),908-913.
[ 李晋, 宋天佳, 孟凡超, 李汉霞, 戴玉川, 韩松平,… 韩济生. (2015). 孤独症与正常儿童的痛阈比较研究. 中国疼痛医学杂志>, 21(12),908-913.]
[46] Li, X., Liu, Y., Ye, Q., Lu, X., & Peng, W. (2020). The linkage between first-hand pain sensitivity and empathy for others' pain: Attention matters. Human Brain Mapping, 41(17),4815-4828.
doi: 10.1002/hbm.v41.17URL
[47] Linden, W., Lenz, J.W., & Stossel, C. (1996). Alexithymia, defensiveness and cardiovascular reactivity to stress. Journal of Psychosomatic Research, 41(6),575-583.
pmid: 9032721
[48] Liss, M., Saulnier, C., Fein, D., & Kinsbourne, M. (2006). Sensory and attention abnormalities in autistic spectrum disorders. Autism, 10(2),155-172.
doi: 10.1177/1362361306062021URL
[49] Liu, Y., Meng, J., Yao, M., Ye, Q., Fan, B., & Peng, W. (2019). Hearing other's pain is associated with sensitivity to physical pain: An ERP study. Biological Psychology, 145,150-158.
doi: 10.1016/j.biopsycho.2019.03.011URL
[50] Magerl, W., Ali, Z., Ellrich, J., Meyer, R.A., & Treede, R.D. (1999). C- and A delta-fiber components of heat-evoked cerebral potentials in healthy human subjects. Pain, 82(2),127-137.
pmid: 10467918
[51] Mahler, M.S. (1952). On child psychosis and schizophrenia. The Psychoanalytic Study of the Child, 7(1),286-305.
doi: 10.1080/00797308.1952.11823164URL
[52] McCaffery, M., & Pasero, C.L. (1997). Pain ratings: The fifth vital sign. American Journal of Practical Nursing, 97(2),15-16.
[53] McGrath, P.J., Rosmus, C., Canfield, C., Campbell, M.A., & BSc, A.H. (1998). Behaviours caregivers use to determine pain in non-verbal, cognitively impaired individuals. Developmental Medicine & Child Neurology, 40(5),340-343.
[54] Meints, S.M., Mawla, I., Napadow, V., Kong, J., Gerber, J., Chan, S.T.,... Edwards, R.R. (2019). The relationship between catastrophizing and altered pain sensitivity in patients with chronic low-back pain. Pain, 160(4),833-843.
doi: 10.1097/j.pain.0000000000001461URL
[55] Meng, J., Chen, Y., & Huang, X. (2010). Influencing factors and the mechanism of empathy for pain. Advances in Psychological Science, 18(3),432-440.
[ 孟景, 陈有国, 黄希庭. (2010). 疼痛共情的影响因素及其认知机制. 心理科学进展>, 18(3),432-440.]
[56] Militerni, R., Bravaccio, C., Falco, C., Puglisi-Allegra, S., Pascucci, T., & Fico, C. (2000). Pain reactivity in children with autistic disorder. The Journal of Headache and Pain, 1(1),53-56.
doi: 10.1007/s101940050011URL
[57] Minshew, N.J., & Hobson, J.A. (2008). Sensory sensitivities and performance on sensory perceptual tasks in high-functioning individuals with autism. Journal of Autism and Developmental Disorders, 38(8),1485-1498.
doi: 10.1007/s10803-007-0528-4pmid: 18302014
[58] Moore, D.J. (2015). Acute pain experience in individuals with autism spectrum disorders: A review. Autism, 19(4),387-399.
doi: 10.1177/1362361314527839URL
[59] Mundy, P., & Neal, A.R. (2001). Neural plasticity, joint attention, and a transactional social-orienting model of autism. International Review of Research in Mental Retardation, 23,139-168.
[60] Nader, R., Oberlander, T.F., Chambers, C.T., & Craig, K.D. (2004). Expression of pain in children with autism. Clinical Journal of Pain, 20(2),88-97.
pmid: 14770048
[61] Nahman-Averbuch, H., Shefi, T., Schneider, V.J., Li, D., Ding, L., King, C.D., & Coghill, R.C. (2018). Quantitative sensory testing in patients with migraine: A systematic review and meta-analysis. Pain, 159(7),1202-1223.
doi: 10.1097/j.pain.0000000000001231pmid: 29781957
[62] Peyron, R., Laurent, B., & García-Larrea, L. (2000). Functional imaging of brain responses to pain. A review and meta-analysis (2000). Neurophysiologie Clinique, 30(5),263-288.
doi: 10.1016/S0987-7053(00)00227-6URL
[63] Ploghaus, A., Narain, C., Beckmann, C.F., Clare, S., Bantick, S., Wise, R.,... Tracey, I. (2001). Exacerbation of pain by anxiety is associated with activity in a hippocampal network. Journal of Neuroscience, 21(24),9896-9903.
doi: 10.1523/JNEUROSCI.21-24-09896.2001URL
[64] Price, D.D., Milling, L.S., Kirsch, I., Duff, A., Montgomery, G.H., & Nicholls, S.S. (1999). An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain, 83(2),147-156.
pmid: 10534585
[65] Rainville, P., Feine, J.S., Bushnell, M.C., & Duncan, G.H. (1992). A psychophysical comparison of sensory and affective responses to four modalities of experimental pain. Somatosensory and Motor Research, 9(4),265-277.
pmid: 1492527
[66] Raja, S.N., Carr, D.B., Cohen, M., Finnerup, N.B., Flor, H., Gibson, S.,... Vader, K. (2020). The revised international association for the study of pain definition of pain: Concepts, challenges, and compromises. Pain, 161(9),1976-1982.
doi: 10.1097/j.pain.0000000000001939URL
[67] * Rattaz, C., Dubois, A., Michelon, C., Viellard, M., Poinso, F., & Baghdadli, A. (2013). How do children with autism spectrum disorders express pain? A comparison with developmentally delayed and typically developing children. Pain, 154(10),2007-2013.
doi: 10.1016/j.pain.2013.06.011URL
[68] Reed, W.R., Florax, R.J., & Poot, J. (2015). A Monte Carlo analysis of alternative meta-analysis estimators in the presence of publication bias (No. 2015-9). Economics Discussion Papers.
[69] * Riquelme, I., Hatem, S.M., & Montoya, P. (2016). Abnormal pressure pain, touch sensitivity, proprioception, and manual dexterity in children with autism spectrum disorders. Neural Plasticity, 2016,1723401.
[70] Rogers, S.J., & Ozonoff, S. (2005). Annotation: What do we know about sensory dysfunction in autism? A critical review of the empirical evidence. Journal of Child Psychology and Psychiatry, 46(12),1255-1268.
pmid: 16313426
[71] Rothstein, H.R., Sutton, A.J., & Borenstein, M. (2005). Publication bias in meta-analysis. In H. R. Rothstein, A. J. Sutton & M. Borenstein (Eds.). Publication bias in meta-analysis: Prevention, assessment and adjustments, (pp.1-7). John Wiley & Sons, Ltd.
[72] Schnitzler, A., & Ploner, M. (2000). Neurophysiology and functional neuroanatomy of pain perception. Journal of Clinical Neurophysiology, 17(6),592-603.
pmid: 11151977
[73] Simone, D.A., & Kajander, K.C. (1997). Responses of cutaneous A-fiber nociceptors to noxious cold. Journal of Neurophysiology, 77(4),2049-2060.
doi: 10.1152/jn.1997.77.4.2049URL
[74] Smith, A. (2009). The empathy imbalance hypothesis of autism: A theoretical approach to cognitive and emotional empathy in autistic development. The Psychological Record, 59(3),489-510.
doi: 10.1007/BF03395675URL
[75] Stubbs, B., Thompson, T., Acaster, S., Vancampfort, D., Gaughran, F., & Correll, C.U. (2015). Decreased pain sensitivity among people with schizophrenia: A meta-analysis of experimental pain induction studies. Pain, 156(11),2121-2131.
doi: 10.1097/j.pain.0000000000000304URL
[76] Summers, J., Shahrami, A., Cali, S., D'Mello, C., Kako, M., Palikucin-Reljin, A.,... Lunsky, Y. (2017). Self-injury in autism spectrum disorder and intellectual disability: Exploring the role of reactivity to pain and sensory input. Brain Sciences, 7(11),140.
doi: 10.3390/brainsci7110140URL
[77] Tesarz, J., Schuster, A.K., Hartmann, M., Gerhardt, A., & Eich, W. (2012). Pain perception in athletes compared to normally active controls: A systematic review with meta-analysis. Pain, 153(6),1253-1262.
doi: 10.1016/j.pain.2012.03.005pmid: 22607985
[78] * Thaler, H., Skewes, J.C., Gebauer, L., Christensen, P., Prkachin, K.M., & Elmholdt, E.-M.J. (2018). Typical pain experience but underestimation of others' pain: Emotion perception in self and others in autism spectrum disorder. Autism, 22(6),751-762.
doi: 10.1177/1362361317701269pmid: 28691518
[79] * Tordjman, S., Anderson, G.M., Botbol, M., Brailly-Tabard, S., Perez-Diaz, F., Graignic, R.,... Bronsard, G. (2009). Pain reactivity and plasma beta-endorphin in children and adolescents with autistic disorder. PLoS ONE, 4(8),e5289.
doi: 10.1371/journal.pone.0005289URL
[80] Tordjman, S., Antoine, C., Cohen, D.J., Gauvain-Piquard, A., Carlier, M., Roubertoux, P., & Ferrari, P. (1999). Study of the relationships between self-injurious behavior and pain reactivity in infantile autism. Encephale, 25(2),122-134.
pmid: 10370885
[81] Tracey, I. (2011). Can neuroimaging studies identify pain endophenotypes in humans? Nature Reviews Neurology, 7(3),173-181.
doi: 10.1038/nrneurol.2011.4pmid: 21304481
[82] * Vaughan, S., McGlone, F., Poole, H., & Moore, D.J. (2019). A quantitative sensory testing approach to pain in autism spectrum disorders. Journal of Autism and Developmental Disorders, 50(5),1607-1620.
doi: 10.1007/s10803-019-03918-0URL
[83] Vierck, C.J., Whitsel, B.L., Favorov, O.V., Brown, A.W., & Tommerdahl, M. (2013). Role of primary somatosensory cortex in the coding of pain. Pain, 154(3),334-344.
doi: 10.1016/j.pain.2012.10.021URL
[84] Watson, L.R., Patten, E., Baranek, G.T., Poe, M., Boyd, B.A., Freuler, A., & Lorenzi, J. (2011). Differential associations between sensory response patterns and language, social, and communication measures in children with autism or other developmental disabilities. Journal of Speech, Language, and Hearing Research, 54(6),1562-1576.
doi: 10.1044/1092-4388(2011/10-0029)URL
[85] Wiech, K., Ploner, M., & Tracey, I. (2008). Neurocognitive aspects of pain perception. Trends in Cognitive Sciences, 12(8),306-313.
doi: 10.1016/j.tics.2008.05.005URL
[86] Wigham, S., Rodgers, J., South, M., McConachie, H., & Freeston, M. (2015). The interplay between sensory processing abnormalities, intolerance of uncertainty, anxiety and restricted and repetitive behaviours in autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(4),943-952.
doi: 10.1007/s10803-014-2248-xpmid: 25261248
[87] * Yasuda, Y., Hashimoto, R., Nakae, A., Kang, H., Ohi, K., Yamamori, H.,... Takeda, M. (2016). Sensory cognitive abnormalities of pain in autism spectrum disorder: A case-control study. Annals of General Psychiatry, 15,8.
doi: 10.1186/s12991-016-0095-1URL
[88] Zachor, D.A., & Ben-Itzchak, E. (2013). The relationship between clinical presentation and unusual sensory interests in autism spectrum disorders: A preliminary investigation. Journal of Autism and Developmental Disorders, 44,229-235.
doi: 10.1007/s10803-013-1867-yURL
[89] Zhang, Y., & Yang, G. (2014). An overview of the abnormal sensory response of people with autism spectrum disorders. Chinese Journal of Special Education, (7),30-36.
[ 张永盛, 杨广学. (2014). 自闭症谱系障碍患者异常感觉反应研究综述. 中国特殊教育>, (7),30-36.]




[1]辛素飞, 梁鑫, 盛靓, 赵智睿. 我国内地教师主观幸福感的变迁(2002~2019)：横断历史研究的视角[J]. 心理学报, 2021, 53(8): 875-889.
[2]张亚利, 李森, 俞国良. 社交媒体使用与错失焦虑的关系：一项元分析[J]. 心理学报, 2021, 53(3): 273-290.
[3]李雄,李祚山,向滨洋,孟景. 注意线索对自闭特质个体疼痛共情的影响：来自事件相关电位的证据[J]. 心理学报, 2020, 52(3): 294-306.
[4]韩毅初, 温恒福, 程淑华, 张淳淦, 李欣. 流动儿童歧视知觉与心理健康关系的元分析[J]. 心理学报, 2020, 52(11): 1313-1326.
[5]柳武妹, 马增光, 卫旭华. 拥挤影响消费者情绪和购物反应的元分析[J]. 心理学报, 2020, 52(10): 1237-1252.
[6]高世欢,陈顺森,苏彦捷,林彩云. 视觉正常的自闭症儿童双眼注视点间距的特点及其意义[J]. 心理学报, 2019, 51(9): 1018-1027.
[7]任志洪,赵春晓,卞诚,朱文臻,江光荣,祝卓宏. 接纳承诺疗法的作用机制——基于元分析结构方程模型[J]. 心理学报, 2019, 51(6): 662-676.
[8]任志洪, 张雅文, 江光荣. 正念冥想对焦虑症状的干预： 效果及其影响因素元分析[J]. 心理学报, 2018, 50(3): 283-305.
[9]赵梦雪;冯正直;王毅超;赖薇;胡丰;刘可愚;夏凡;蒋娟;王佳;夏蕾. 1993~2013年常驻高海拔地区军人心理健康状态的横断历史研究[J]. 心理学报, 2017, 49(5): 653-662.
[10]任志洪, 阮怡君, 赵庆柏, 张微, 赖丽足, 江光荣. 抑郁障碍和焦虑障碍治疗的神经心理机制 ——脑成像研究的ALE元分析[J]. 心理学报, 2017, 49(10): 1302-1321.
[11]于增艳;赵阿勐;刘爱书. 儿童期受虐经历与抑郁的元分析[J]. 心理学报, 2017, 49(1): 40-49.
[12]谢和平;王福兴;周宗奎;吴鹏. 多媒体学习中线索效应的元分析[J]. 心理学报, 2016, 48(5): 540-555.
[13]张淑华;刘兆延. 组织认同与离职意向关系的元分析[J]. 心理学报, 2016, 48(12): 1561-1573.
[14]黄四林;侯佳伟;张梅;辛自强;张红川;孙铃;窦东徽. 中国农民工心理健康水平变迁的横断历史研究：1995~2011[J]. 心理学报, 2015, 47(4): 466-477.
[15]周文霞;谢宝国;辛迅;白光林:苗仁涛. 人力资本、社会资本和心理资本影响中国员工职业成功的元分析[J]. 心理学报, 2015, 47(2): 251-263.





PDF全文下载地址:

http://journal.psych.ac.cn/xlxb/CN/article/downloadArticleFile.do?attachType=PDF&id=4957
相关话题/心理 欧洲 机械 阈限 青少年

Free考研考试FreeKaoYan.Com
欢迎来到Free考研考试，"为实现人生的Free而奋斗"

© 2020 FreeKaoYan! . All rights reserved.